Aliases for NPFFR1 Gene

Aliases for NPFFR1 Gene

  • Neuropeptide FF Receptor 1 2 3 4 5
  • RFamide-Related Peptide Receptor OT7T022 3 4
  • G-Protein Coupled Receptor 147 3 4
  • Neuropeptide FF 1 2 3
  • NPFF1R1 2 3
  • OT7T022 2 3
  • GPR147 3 4
  • NPFF1 3 4
  • G Protein-Coupled Receptor 147 2
  • NPFFR1 5

External Ids for NPFFR1 Gene

Previous HGNC Symbols for NPFFR1 Gene

  • GPR147

Previous GeneCards Identifiers for NPFFR1 Gene

  • GC10M071685
  • GC10M072014
  • GC10M066007

Summaries for NPFFR1 Gene

GeneCards Summary for NPFFR1 Gene

NPFFR1 (Neuropeptide FF Receptor 1) is a Protein Coding gene. Diseases associated with NPFFR1 include Hypoactive Sexual Desire Disorder. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NPFFR2.

UniProtKB/Swiss-Prot Summary for NPFFR1 Gene

  • Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for NPFFR1 Gene

  • Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein-coupled receptors that are divided into two subtypes; NPFF1 and NPFF2. NPFF receptors have been implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception.

Gene Wiki entry for NPFFR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPFFR1 Gene

Genomics for NPFFR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NPFFR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J070283 Promoter 0.7 Ensembl 250.7 +0.0 3 0.8 SIN3A BHLHE40 CTCF ZNF48 ZNF664 RFX1 RAD21 SMC3 EZH2 NPFFR1 PPA1 piR-34593-006 MK280269-008
GH10J070282 Enhancer 0.3 Ensembl 250.7 +1.7 1703 0.2 SPI1 NPFFR1 piR-34593-006 PPA1 MK280269-008
GH10J070231 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 +50.5 50514 4.6 ZNF207 NCOR1 MYC IKZF1 ZNF600 JUND ZNF592 ATF2 POLR2A CEBPA PPA1 lnc-H2AFY2-4 lnc-PPA1-1 AIFM2 SAR1A LRRC20 CEP57L1P1 NPFFR1 lnc-NPFFR1-1 MK280269-008
GH10J070322 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 -40.3 -40263 4.9 NCOR1 ZNF600 ZIC2 NFIC YY1 MXD4 HES1 KMT2B THAP11 FOXA2 PPA1 NPFFR1 NODAL LRRC20 HE856082 RF00017-615 MK280269-008
GH10J070089 Promoter/Enhancer 1.2 Ensembl ENCODE 15.5 +191.9 191929 4.3 CEBPA HOMEZ THAP11 KDM6A SMAD4 ZNF511 SAP130 MIER3 RARA GABPB1 NPFFR1 TYSND1 CALM2P2 SAR1A LRRC20 piR-51223 HSALNG0078620 MACROH2A2 HSALNG0078619 AIFM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPFFR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPFFR1

Top Transcription factor binding sites by QIAGEN in the NPFFR1 gene promoter:
  • AREB6
  • Bach2
  • GATA-1
  • LyF-1
  • MZF-1
  • p53
  • Pax-4a
  • Pax-5
  • SRY
  • YY1

Genomic Locations for NPFFR1 Gene

Latest Assembly
chr10:70,247,329-70,284,004
(GRCh38/hg38)
Size:
36,676 bases
Orientation:
Minus strand

Previous Assembly
chr10:72,007,085-72,043,760
(GRCh37/hg19 by Entrez Gene)
Size:
36,676 bases
Orientation:
Minus strand

chr10:72,007,085-72,043,432
(GRCh37/hg19 by Ensembl)
Size:
36,348 bases
Orientation:
Minus strand

Genomic View for NPFFR1 Gene

Genes around NPFFR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPFFR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPFFR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPFFR1 Gene

Proteins for NPFFR1 Gene

  • Protein details for NPFFR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ6-NPFF1_HUMAN
    Recommended name:
    Neuropeptide FF receptor 1
    Protein Accession:
    Q9GZQ6
    Secondary Accessions:
    • A2RRF0
    • Q8NGR0
    • Q96RN3

    Protein attributes for NPFFR1 Gene

    Size:
    430 amino acids
    Molecular mass:
    47819 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05950.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NPFFR1 Gene

Post-translational modifications for NPFFR1 Gene

  • Glycosylation at Asn10, Asn18, Asn29, Asn113, and Asn195
  • Modification sites at PhosphoSitePlus

Other Protein References for NPFFR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPFFR1 Gene

Domains & Families for NPFFR1 Gene

Gene Families for NPFFR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for NPFFR1 Gene

InterPro:
Blocks:
  • Neuropeptide FF receptor family signature
  • Type 1 neuropeptide FF receptor signature

Suggested Antigen Peptide Sequences for NPFFR1 Gene

GenScript: Design optimal peptide antigens:
  • RFamide-related peptide receptor OT7T022 (NPFF1_HUMAN)
  • Neuropeptide FF receptor 1 (Q5T6D8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZQ6

UniProtKB/Swiss-Prot:

NPFF1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NPFFR1: view

Function for NPFFR1 Gene

Molecular function for NPFFR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Phenotypes From GWAS Catalog for NPFFR1 Gene

Gene Ontology (GO) - Molecular Function for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA,NAS 11024015
GO:0005515 protein binding IPI 32296183
GO:0008188 neuropeptide receptor activity NAS 11024015
GO:0042277 peptide binding IBA 21873635
genes like me logo Genes that share ontologies with NPFFR1: view
genes like me logo Genes that share phenotypes with NPFFR1: view

Animal Models for NPFFR1 Gene

MGI Knock Outs for NPFFR1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPFFR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPFFR1 Gene

Localization for NPFFR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPFFR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPFFR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0005929 cilium IDA 28154160
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPFFR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPFFR1 Gene

Pathways & Interactions for NPFFR1 Gene

genes like me logo Genes that share pathways with NPFFR1: view

SIGNOR curated interactions for NPFFR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NPFFR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NPFFR1: view

Drugs & Compounds for NPFFR1 Gene

(20) Drugs for NPFFR1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pancreatic Polypeptide Investigational Pharma 24
neuropeptide FF Pharma Agonist, Full agonist Endogenous NPFF1 and NPFF2 agonist 0
BIBP3226 Pharma Antagonist 0
Neuropeptide AF (human) Pharma Implicated in pain modulation, opioid function and metabolism 0
Neuropeptide SF (mouse, rat) Pharma NPFF1 and NPFF2 agonist 0

(1) Additional Compounds for NPFFR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for NPFFR1 Gene

Compound Action Cas Number
Neuropeptide AF (human) Implicated in pain modulation, opioid function and metabolism 192387-38-5
Neuropeptide FF Endogenous NPFF1 and NPFF2 agonist 99566-27-5
Neuropeptide SF (mouse, rat) NPFF1 and NPFF2 agonist 230960-31-3

(5) ApexBio Compounds for NPFFR1 Gene

Compound Action Cas Number
BIBP 3226 trifluoroacetate Mixed NPY1-R and NPFF receptor inhibitor 1068148-47-9
Neuropeptide AF (human) 192387-38-5
Neuropeptide SF (mouse, rat) 230960-31-3
RF 9 neuropeptide FF receptors antagonist 876310-60-0
RFRP 3 (human) 311309-27-0
genes like me logo Genes that share compounds with NPFFR1: view

Drug products for research

Transcripts for NPFFR1 Gene

mRNA/cDNA for NPFFR1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPFFR1

Alternative Splicing Database (ASD) splice patterns (SP) for NPFFR1 Gene

No ASD Table

Relevant External Links for NPFFR1 Gene

GeneLoc Exon Structure for
NPFFR1

Expression for NPFFR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPFFR1 Gene

mRNA differential expression in normal tissues according to GTEx for NPFFR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.8), Brain - Cerebellum (x7.8), and Nerve - Tibial (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPFFR1

SOURCE GeneReport for Unigene cluster for NPFFR1 Gene:

Hs.302026

Evidence on tissue expression from TISSUES for NPFFR1 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with NPFFR1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPFFR1 Gene

Orthologs for NPFFR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPFFR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NPFFR1 29 30
  • 99.15 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NPFFR1 29 30
  • 89.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NPFFR1 29
  • 89.2 (n)
Mouse
(Mus musculus)
Mammalia Npffr1 29 16 30
  • 86.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Npffr1 29
  • 86.12 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NPFFR1 30
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NPFFR1 30
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NPFFR1 29
  • 75.77 (n)
NPFF1 30
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NPFFR1 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia npffr1 29
  • 65.8 (n)
Zebrafish
(Danio rerio)
Actinopterygii npffr1l3 29
  • 68.04 (n)
NPFFR1 30
  • 59 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta SIFR 30
  • 16 (a)
OneToMany
Species where no ortholog for NPFFR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NPFFR1 Gene

ENSEMBL:
Gene Tree for NPFFR1 (if available)
TreeFam:
Gene Tree for NPFFR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NPFFR1: view image
Alliance of Genome Resources:
Additional Orthologs for NPFFR1

Paralogs for NPFFR1 Gene

(8) SIMAP similar genes for NPFFR1 Gene using alignment to 1 proteins:

  • NPFF1_HUMAN
genes like me logo Genes that share paralogs with NPFFR1: view

Variants for NPFFR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPFFR1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs140283186 Likely Benign: not provided 70,255,521(-) G/C
NM_022146.5(NPFFR1):c.729C>G (p.Leu243=)
SYNONYMOUS
rs186499075 Benign: not provided 70,255,434(-) C/T
NM_022146.5(NPFFR1):c.816G>A (p.Leu272=)
SYNONYMOUS
rs200754367 Benign: not provided 70,260,705(-) G/A
NM_022146.5(NPFFR1):c.357C>T (p.Ser119=)
SYNONYMOUS
rs61746113 Benign: not provided 70,255,663(-) C/A
NM_022146.5(NPFFR1):c.587G>T (p.Arg196Leu)
MISSENSE
rs61746115 Benign: not provided 70,255,673(-) C/A
NM_022146.5(NPFFR1):c.577G>T (p.Ala193Ser)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NPFFR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NPFFR1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
esv3578973 CNV loss 25503493
nsv1041698 CNV gain 25217958
nsv831908 CNV gain 17160897

Variation tolerance for NPFFR1 Gene

Gene Damage Index Score: 7.40; 81.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPFFR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPFFR1
Leiden Open Variation Database (LOVD)
NPFFR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPFFR1 Gene

Disorders for NPFFR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPFFR1 Gene - From: COP

Disorder Aliases PubMed IDs
hypoactive sexual desire disorder
  • lack or loss of sexual desire
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NPFFR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NPFFR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPFFR1 Gene

Publications for NPFFR1 Gene

  1. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. (PMID: 11024015) Bonini JA … Borowsky B (The Journal of biological chemistry 2000) 2 3 4 22
  2. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. (PMID: 11025660) Hinuma S … Fujino M (Nature cell biology 2000) 3 4 22
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 40
  5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3

Products for NPFFR1 Gene

Sources for NPFFR1 Gene