Aliases for NPFFR1 Gene
External Ids for NPFFR1 Gene
Previous HGNC Symbols for NPFFR1 Gene
Previous GeneCards Identifiers for NPFFR1 Gene
GeneCards Summary for NPFFR1 Gene
NPFFR1 (Neuropeptide FF Receptor 1) is a Protein Coding gene. Diseases associated with NPFFR1 include Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NPFFR2.
UniProtKB/Swiss-Prot Summary for NPFFR1 Gene
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Neuropeptide FF/AF (NPFF) receptors are a group of Gi/Go-protein-coupled receptors that are divided into two subtypes; NPFF1 and NPFF2. NPFF receptors have been implicated in hormonal modulation, regulation of food intake, thermoregulation and nociception.