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Aliases for NPFF Gene

Aliases for NPFF Gene

  • Neuropeptide FF-Amide Peptide Precursor 2 3 5
  • Pro-FMRFamide-Related Neuropeptide FF 3
  • FMRFamide-Related Peptides 4
  • FMRFAL 3

External Ids for NPFF Gene

Previous GeneCards Identifiers for NPFF Gene

  • GC12M053896
  • GC12M054012
  • GC12M053618
  • GC12M052186
  • GC12M050940

Summaries for NPFF Gene

Entrez Gene Summary for NPFF Gene

  • This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

GeneCards Summary for NPFF Gene

NPFF (Neuropeptide FF-Amide Peptide Precursor) is a Protein Coding gene. Diseases associated with NPFF include Pain Agnosia and Agnosia. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for NPFF Gene

  • Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.

Gene Wiki entry for NPFF Gene

Additional gene information for NPFF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPFF Gene

Genomics for NPFF Gene

GeneHancer (GH) Regulatory Elements for NPFF Gene

Promoters and enhancers for NPFF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I053508 Enhancer 1 Ensembl ENCODE 550.8 -1.1 -1083 1.1 ELF3 RB1 ARID4B SIN3A ZNF2 IRF4 ZSCAN9 RAD21 RFX5 ELK1 NPFF ATP5MC2 PIR52796 ATF7 ENSG00000267281
GH12I053504 Enhancer 0.6 ENCODE dbSUPER 550.8 +1.8 1813 3 ZFHX2 POLR2A NPFF PRR13 ENSG00000270175 TARBP2 ENSG00000267281
GH12I053971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -482.6 -482605 36.8 FEZF1 DMAP1 IRF4 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC ZNF610 HOXC11 HOXC9 HOXC6 HOXC10 GC12P054010 GC12P054044 MIR196A2 HNRNPA1 ZNF740 ENSG00000258344
GH12I054277 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 -773.4 -773427 7.1 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC CBX5 HNRNPA1 SP1 PCBP2 MAP3K12 AAAS ENSG00000258344 COPZ1 ATF7 TARBP2
GH12I052894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +604.7 604710 16.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC12M052900 ZNF740 AAAS PCBP2 SP1 MAP3K12 ATF7 LOC100652999 EIF4B ENSG00000257808
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NPFF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPFF gene promoter:

Genomic Locations for NPFF Gene

Genomic Locations for NPFF Gene
chr12:53,506,690-53,507,638
(GRCh38/hg38)
Size:
949 bases
Orientation:
Minus strand
chr12:53,900,474-53,901,422
(GRCh37/hg19)

Genomic View for NPFF Gene

Genes around NPFF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPFF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPFF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPFF Gene

Proteins for NPFF Gene

  • Protein details for NPFF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15130-NPFF_HUMAN
    Recommended name:
    Pro-FMRFamide-related neuropeptide FF
    Protein Accession:
    O15130
    Secondary Accessions:
    • Q3SXL4

    Protein attributes for NPFF Gene

    Size:
    113 amino acids
    Molecular mass:
    12440 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NPFF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NPFF Gene

Post-translational modifications for NPFF Gene

No Post-translational modifications

Other Protein References for NPFF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPFF Gene

Domains & Families for NPFF Gene

Gene Families for NPFF Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NPFF Gene

Suggested Antigen Peptide Sequences for NPFF Gene

Graphical View of Domain Structure for InterPro Entry

O15130

UniProtKB/Swiss-Prot:

NPFF_HUMAN :
  • Belongs to the FARP (FMRFamide related peptide) family.
Family:
  • Belongs to the FARP (FMRFamide related peptide) family.
genes like me logo Genes that share domains with NPFF: view

Function for NPFF Gene

Molecular function for NPFF Gene

GENATLAS Biochemistry:
FMRF-amide related peptides,precursor
UniProtKB/Swiss-Prot Function:
Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.

Phenotypes From GWAS Catalog for NPFF Gene

Gene Ontology (GO) - Molecular Function for NPFF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0005102 receptor binding TAS 9224703
GO:0005184 neuropeptide hormone activity IBA --
genes like me logo Genes that share ontologies with NPFF: view
genes like me logo Genes that share phenotypes with NPFF: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPFF Gene

Localization for NPFF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPFF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPFF gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for NPFF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
GO:0030425 dendrite IBA,IEA --
GO:0031982 vesicle IEA --
GO:0043204 perikaryon IEA,IBA --
genes like me logo Genes that share ontologies with NPFF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPFF Gene

Pathways & Interactions for NPFF Gene

genes like me logo Genes that share pathways with NPFF: view

SIGNOR curated interactions for NPFF Gene

Activates:

Gene Ontology (GO) - Biological Process for NPFF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002438 acute inflammatory response to antigenic stimulus IEA --
GO:0003254 regulation of membrane depolarization IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007218 neuropeptide signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with NPFF: view

Drugs & Compounds for NPFF Gene

(6) Drugs for NPFF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for NPFF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NPFF: view

Transcripts for NPFF Gene

mRNA/cDNA for NPFF Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPFF Gene

Neuropeptide FF-amide peptide precursor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NPFF Gene

ExUns: 1 ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for NPFF Gene

GeneLoc Exon Structure for
NPFF
ECgene alternative splicing isoforms for
NPFF

Expression for NPFF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPFF Gene

NURSA nuclear receptor signaling pathways regulating expression of NPFF Gene:

NPFF

SOURCE GeneReport for Unigene cluster for NPFF Gene:

Hs.733076

Evidence on tissue expression from TISSUES for NPFF Gene

  • Nervous system(2.9)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with NPFF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPFF Gene

Orthologs for NPFF Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPFF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NPFF 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia NPFF 33 34
  • 83.19 (n)
rat
(Rattus norvegicus)
Mammalia Npff 33
  • 77.47 (n)
mouse
(Mus musculus)
Mammalia Npff 33 16 34
  • 75 (n)
lizard
(Anolis carolinensis)
Reptilia NPFF 34
  • 41 (a)
OneToOne
Species where no ortholog for NPFF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPFF Gene

ENSEMBL:
Gene Tree for NPFF (if available)
TreeFam:
Gene Tree for NPFF (if available)

Paralogs for NPFF Gene

No data available for Paralogs for NPFF Gene

Variants for NPFF Gene

Sequence variations from dbSNP and Humsavar for NPFF Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000102741 -- 53,506,644(-) G/A downstream_transcript_variant
rs1000789125 -- 53,509,566(-) C/T upstream_transcript_variant
rs1001018949 -- 53,509,159(-) C/T upstream_transcript_variant
rs1005092602 -- 53,506,512(-) C/G downstream_transcript_variant
rs1006466788 -- 53,507,317(-) A/C 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NPFF Gene

Variant ID Type Subtype PubMed ID
nsv983486 CNV duplication 23825009

Variation tolerance for NPFF Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPFF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPFF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPFF Gene

Disorders for NPFF Gene

MalaCards: The human disease database

(3) MalaCards diseases for NPFF Gene - From: DISEASES

Disorder Aliases PubMed IDs
pain agnosia
  • analgesia
agnosia
  • dyspraxia
specific developmental disorder
- elite association - COSMIC cancer census association via MalaCards
Search NPFF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NPFF

genes like me logo Genes that share disorders with NPFF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPFF Gene

Publications for NPFF Gene

  1. A human gene encoding morphine modulating peptides related to NPFF and FMRFamide. (PMID: 9224703) Perry SJ … Burke JF (FEBS letters 1997) 2 3 4 22 58
  2. Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF. (PMID: 11587714) Catarsi S … Séguéla P (Neuropharmacology 2001) 3 4 22 58
  3. Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity. (PMID: 17224450) Roumy M … Mollereau C (The Journal of biological chemistry 2007) 3 22 58
  4. Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line. (PMID: 16336216) Ankö ML … Panula P (Journal of neurochemistry 2006) 3 22 58
  5. Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus. (PMID: 12609745) Laemmle B … Wieland HA (Regulatory peptides 2003) 3 22 58

Products for NPFF Gene

Sources for NPFF Gene

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