Aliases for NPFF Gene
External Ids for NPFF Gene
Previous GeneCards Identifiers for NPFF Gene
This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
GeneCards Summary for NPFF Gene
NPFF (Neuropeptide FF-Amide Peptide Precursor) is a Protein Coding gene. Diseases associated with NPFF include Migraine Without Aura and Migraine With Aura. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuropeptide hormone activity.
UniProtKB/Swiss-Prot Summary for NPFF Gene
Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.