Aliases for NPDC1 Gene

Aliases for NPDC1 Gene

  • Neural Proliferation, Differentiation And Control 1 2 3 5
  • Neural Proliferation Differentiation And Control Protein 1 3 4
  • NPDC-1 3 4
  • CAB-1 3
  • CAB- 3
  • CAB1 3
  • CAB 3

External Ids for NPDC1 Gene

Previous GeneCards Identifiers for NPDC1 Gene

  • GC09M131083
  • GC09M131623
  • GC09M133373
  • GC09M135291
  • GC09M137209
  • GC09M139053
  • GC09M139933
  • GC09M109393

Summaries for NPDC1 Gene

GeneCards Summary for NPDC1 Gene

NPDC1 (Neural Proliferation, Differentiation And Control 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for NPDC1 Gene

  • Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

Gene Wiki entry for NPDC1 Gene

Additional gene information for NPDC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPDC1 Gene

Genomics for NPDC1 Gene

GeneHancer (GH) Regulatory Elements for NPDC1 Gene

Promoters and enhancers for NPDC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPDC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPDC1

Top Transcription factor binding sites by QIAGEN in the NPDC1 gene promoter:
  • GATA-1
  • GATA-2
  • GATA-3
  • NRSF form 1
  • NRSF form 2
  • RFX1
  • SEF-1 (1)

Genomic Locations for NPDC1 Gene

Genomic Locations for NPDC1 Gene
chr9:137,039,457-137,046,224
(GRCh38/hg38)
Size:
6,768 bases
Orientation:
Minus strand
chr9:139,933,909-139,940,676
(GRCh37/hg19)
Size:
6,768 bases
Orientation:
Minus strand

Genomic View for NPDC1 Gene

Genes around NPDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPDC1 Gene

Proteins for NPDC1 Gene

  • Protein details for NPDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQX5-NPDC1_HUMAN
    Recommended name:
    Neural proliferation differentiation and control protein 1
    Protein Accession:
    Q9NQX5
    Secondary Accessions:
    • Q5SPY8
    • Q9BTD6
    • Q9BXT3
    • Q9NQS2
    • Q9Y434

    Protein attributes for NPDC1 Gene

    Size:
    325 amino acids
    Molecular mass:
    34516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPDC1 Gene

Post-translational modifications for NPDC1 Gene

  • Glycosylation at Ser114, Thr115, Thr130, and Ser134
  • Modification sites at PhosphoSitePlus

Other Protein References for NPDC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPDC1 Gene

Domains & Families for NPDC1 Gene

Gene Families for NPDC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NPDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NPDC1 Gene

GenScript: Design optimal peptide antigens:
  • Neural proliferation differentiation and control protein 1 (NPDC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NQX5

UniProtKB/Swiss-Prot:

NPDC1_HUMAN :
  • Belongs to the NPDC1/cab-1 family.
Family:
  • Belongs to the NPDC1/cab-1 family.
genes like me logo Genes that share domains with NPDC1: view

Function for NPDC1 Gene

Molecular function for NPDC1 Gene

UniProtKB/Swiss-Prot Function:
Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).

Phenotypes From GWAS Catalog for NPDC1 Gene

Gene Ontology (GO) - Molecular Function for NPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NPDC1: view

Phenotypes for NPDC1 Gene

MGI mutant phenotypes for NPDC1:
inferred from 1 alleles
GenomeRNAi human phenotypes for NPDC1:
genes like me logo Genes that share phenotypes with NPDC1: view

Animal Models for NPDC1 Gene

MGI Knock Outs for NPDC1:

Animal Model Products

CRISPR Products

miRNA for NPDC1 Gene

miRTarBase miRNAs that target NPDC1

Clone Products

  • Addgene plasmids for NPDC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPDC1 Gene

Localization for NPDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPDC1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPDC1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NPDC1: view

Pathways & Interactions for NPDC1 Gene

PathCards logo

SuperPathways for NPDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NPDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with NPDC1: view

No data available for Pathways by source and SIGNOR curated interactions for NPDC1 Gene

Drugs & Compounds for NPDC1 Gene

No Compound Related Data Available

Transcripts for NPDC1 Gene

mRNA/cDNA for NPDC1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NPDC1

Alternative Splicing Database (ASD) splice patterns (SP) for NPDC1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: - -
SP8: -

Relevant External Links for NPDC1 Gene

GeneLoc Exon Structure for
NPDC1

Expression for NPDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NPDC1 Gene

This gene is overexpressed in Cerebrospinal fluid (45.9), Pancreas (8.2), and Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NPDC1 Gene



Protein tissue co-expression partners for NPDC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPDC1

SOURCE GeneReport for Unigene cluster for NPDC1 Gene:

Hs.719906

mRNA Expression by UniProt/SwissProt for NPDC1 Gene:

Q9NQX5-NPDC1_HUMAN
Tissue specificity: Strongly expressed in adult brain; especially in hippocampus, frontal lobe and temporal lobe.

Evidence on tissue expression from TISSUES for NPDC1 Gene

  • Nervous system(4.9)
  • Kidney(4.2)
  • Eye(4.1)
  • Pancreas(2.8)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with NPDC1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPDC1 Gene

Orthologs for NPDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NPDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NPDC1 31 30
  • 82.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NPDC1 31 30
  • 80.1 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Npdc1 30
  • 79.37 (n)
mouse
(Mus musculus)
Mammalia Npdc1 17 31 30
  • 79 (n)
chimpanzee
(Pan troglodytes)
Mammalia NPDC1 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPDC1 31 30
  • 62.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPDC1 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497919 30
  • 65.84 (n)
Str.10620 30
zebrafish
(Danio rerio)
Actinopterygii npdc1a 30
  • 54.86 (n)
NPDC1 (1 of 2) 31
  • 40 (a)
OneToMany
npdc1 31
  • 39 (a)
OneToMany
sbcb1030 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2189 30
fruit fly
(Drosophila melanogaster)
Insecta Atf-2 31
  • 11 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cab-1 31
  • 15 (a)
OneToOne
Species where no ortholog for NPDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NPDC1 Gene

ENSEMBL:
Gene Tree for NPDC1 (if available)
TreeFam:
Gene Tree for NPDC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NPDC1: view image

Paralogs for NPDC1 Gene

Pseudogenes.org Pseudogenes for NPDC1 Gene

genes like me logo Genes that share paralogs with NPDC1: view

No data available for Paralogs for NPDC1 Gene

Variants for NPDC1 Gene

Additional dbSNP identifiers (rs#s) for NPDC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NPDC1 Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2761561 CNV gain 21179565
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv616004 CNV loss 21841781
nsv616005 CNV loss 21841781
nsv951206 CNV deletion 24416366

Variation tolerance for NPDC1 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPDC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPDC1 Gene

Disorders for NPDC1 Gene

Additional Disease Information for NPDC1

No disorders were found for NPDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NPDC1 Gene

Publications for NPDC1 Gene

  1. Characterization and tissue expression of a novel human gene npdc1. (PMID: 11245976) Qu X … He F (Gene 2001) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Functional analysis of the NPDC-1 gene. (PMID: 15563841) Evrard C … Rouget P (Gene 2004) 3 23 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54

Products for NPDC1 Gene

Sources for NPDC1 Gene