Aliases for NPB Gene
External Ids for NPB Gene
Previous GeneCards Identifiers for NPB Gene
This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]
GeneCards Summary for NPB Gene
NPB (Neuropeptide B) is a Protein Coding gene. Diseases associated with NPB include Niemann-Pick Disease, Type B and Gaucher Disease, Perinatal Lethal. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor binding. An important paralog of this gene is NPW.
UniProtKB/Swiss-Prot Summary for NPB Gene
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.