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Aliases for NPB Gene

Aliases for NPB Gene

  • Neuropeptide B 2 3 3 5
  • Preproprotein L7 3 4
  • Prepro-NPB 2 3
  • PPNPB 3 4
  • PPL7 3 4
  • Preproneuropeptide B 3
  • HPPL7 4
  • L7 3

External Ids for NPB Gene

Previous GeneCards Identifiers for NPB Gene

  • GC17P079351
  • GC17P9I0163
  • GC17P080395
  • GC17P077453
  • GC17P079860
  • GC17P075261

Summaries for NPB Gene

Entrez Gene Summary for NPB Gene

  • This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]

GeneCards Summary for NPB Gene

NPB (Neuropeptide B) is a Protein Coding gene. Diseases associated with NPB include Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor binding.

UniProtKB/Swiss-Prot for NPB Gene

  • May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

Additional gene information for NPB Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPB Gene

Genomics for NPB Gene

GeneHancer (GH) Regulatory Elements for NPB Gene

Promoters and enhancers for NPB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081902 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 +1.5 1522 0.5 FUS RB1 KDM3A CCNT2 GLIS2 POLR2A EGR1 VEZF1 RBM22 EZH2 NPB CEP131 HGS TBCD GPS1 CCDC57 ENSG00000265678 FAAP100 PIR61559 PCYT2
GH17J081897 Enhancer 1 Ensembl ENCODE 650.7 -1.6 -1598 3.4 INSM2 SIN3A ZNF366 ZSCAN5C FOS EGR2 ZNF362 ZEB2 SREBF1 SP1 GC17P081898 NPB ANAPC11
GH17J081682 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 -216.6 -216591 3.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF213 ARL16 HGS ALYREF FOXK2 LOC105371942 CCDC137 PDE6G NPLOC4 TSPAN10 P4HB
GH17J082011 Enhancer 0.8 ENCODE 11.5 +112.7 112713 3.3 ELF3 RAD21 THRB RARA GLIS2 PAF1 TGIF2 SSRP1 GLIS1 ETV4 CENPX CEP131 DCXR ASPSCR1 MYADML2 PYCR1 ENSG00000235296 MAFG SIRT7 PCYT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NPB gene promoter:
  • MyoD
  • ATF-2

Genomic Locations for NPB Gene

Genomic Locations for NPB Gene
2,161 bases
Plus strand
2,161 bases
Plus strand

Genomic View for NPB Gene

Genes around NPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPB Gene

Proteins for NPB Gene

  • Protein details for NPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide B
    Protein Accession:
    Secondary Accessions:
    • A0AUX9
    • A6NJD6
    • B9EJC3

    Protein attributes for NPB Gene

    125 amino acids
    Molecular mass:
    13097 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPB Gene

Post-translational modifications for NPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPB Gene

Domains & Families for NPB Gene

Gene Families for NPB Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NPB Gene

Suggested Antigen Peptide Sequences for NPB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neuropeptide B/W family.
  • Belongs to the neuropeptide B/W family.
genes like me logo Genes that share domains with NPB: view

Function for NPB Gene

Molecular function for NPB Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

Gene Ontology (GO) - Molecular Function for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IEA --
GO:0005515 protein binding IPI 12118011
genes like me logo Genes that share ontologies with NPB: view
genes like me logo Genes that share phenotypes with NPB: view

Animal Models for NPB Gene

MGI Knock Outs for NPB:
  • Npb Npb<tm1Ywa>

Animal Model Products

  • Taconic Biosciences Mouse Models for NPB

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPB

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NPB Gene

Localization for NPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPB Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPB gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPB Gene

Pathways & Interactions for NPB Gene

genes like me logo Genes that share pathways with NPB: view

Gene Ontology (GO) - Biological Process for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA,TAS --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NPB: view

No data available for SIGNOR curated interactions for NPB Gene

Drugs & Compounds for NPB Gene

No Compound Related Data Available

Transcripts for NPB Gene

mRNA/cDNA for NPB Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(372) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPB Gene

Neuropeptide B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPB

Alternative Splicing Database (ASD) splice patterns (SP) for NPB Gene

No ASD Table

Relevant External Links for NPB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NPB Gene

mRNA expression in normal human tissues for NPB Gene

Protein differential expression in normal tissues from HIPED for NPB Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPB Gene

Protein tissue co-expression partners for NPB Gene

NURSA nuclear receptor signaling pathways regulating expression of NPB Gene:


SOURCE GeneReport for Unigene cluster for NPB Gene:


mRNA Expression by UniProt/SwissProt for NPB Gene:

Tissue specificity: Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma.
genes like me logo Genes that share expression patterns with NPB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPB Gene

Orthologs for NPB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPB Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NPB 34 33
  • 83.89 (n)
(Bos Taurus)
Mammalia NPB 34 33
  • 81.33 (n)
(Mus musculus)
Mammalia Npb 16 34 33
  • 72.85 (n)
(Rattus norvegicus)
Mammalia Npb 33
  • 70.67 (n)
(Monodelphis domestica)
Mammalia NPB 34
  • 62 (a)
(Gallus gallus)
Aves NPB 34
  • 41 (a)
(Anolis carolinensis)
Reptilia NPB 34
  • 67 (a)
(Danio rerio)
Actinopterygii npb 34
  • 44 (a)
Species where no ortholog for NPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPB Gene

Gene Tree for NPB (if available)
Gene Tree for NPB (if available)
Evolutionary constrained regions (ECRs) for NPB: view image

Paralogs for NPB Gene

No data available for Paralogs for NPB Gene

Variants for NPB Gene

Sequence variations from dbSNP and Humsavar for NPB Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000430804 -- 81,902,767(+) A/G 3_prime_UTR_variant
rs1000839613 -- 81,901,539(+) T/C upstream_transcript_variant
rs1001118847 -- 81,901,763(+) C/T upstream_transcript_variant
rs1002197257 -- 81,902,296(+) C/T coding_sequence_variant, synonymous_variant
rs1002247141 -- 81,901,879(+) TGTG/TG upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NPB Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for NPB Gene

Gene Damage Index Score: 1.09; 22.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPB Gene

Disorders for NPB Gene

MalaCards: The human disease database

(1) MalaCards diseases for NPB Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search NPB in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPB Gene

Publications for NPB Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S … Parmentier M (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. (PMID: 12118011) Fujii R … Fujino M (The Journal of biological chemistry 2002) 2 3 4 58
  3. Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B. (PMID: 17486669) Kanesaka M … Tokita S (Journal of peptide science : an official publication of the European Peptide Society 2007) 3 22 58
  4. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. (PMID: 16847439) Singh G … Davenport AP (British journal of pharmacology 2006) 3 22 58
  5. G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. (PMID: 15797961) Mazzocchi G … Nussdorfer GG (The Journal of clinical endocrinology and metabolism 2005) 3 22 58

Products for NPB Gene

Sources for NPB Gene

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