This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with highe... See more...

Aliases for NPB Gene

Aliases for NPB Gene

  • Neuropeptide B 2 3 4 5
  • Preproprotein L7 3 4
  • Prepro-NPB 2 3
  • PPNPB 3 4
  • PPL7 3 4
  • Preproneuropeptide B 3
  • HPPL7 4
  • L7 3

External Ids for NPB Gene

Previous GeneCards Identifiers for NPB Gene

  • GC17P079351
  • GC17P9I0163
  • GC17P080395
  • GC17P077453
  • GC17P079860
  • GC17P075261

Summaries for NPB Gene

Entrez Gene Summary for NPB Gene

  • This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]

GeneCards Summary for NPB Gene

NPB (Neuropeptide B) is a Protein Coding gene. Diseases associated with NPB include Niemann-Pick Disease, Type B and Gaucher Disease, Perinatal Lethal. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor binding. An important paralog of this gene is NPW.

UniProtKB/Swiss-Prot Summary for NPB Gene

  • May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

Additional gene information for NPB Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NPB Gene

Genomics for NPB Gene

GeneHancer (GH) Regulatory Elements for NPB Gene

Promoters and enhancers for NPB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081902 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 500.7 +2.1 2054 2 POLR2G SNRNP70 GABPA REST TGIF2 MXI1 POLR2A EZH2 ZNF282 NFIC NPB FAAP100 HEXD OGFOD3 ENSG00000260563 ENSG00000265678 NARF-IT1 ENSG00000262652 TEPSIN CHMP6
GH17J081897 Enhancer 1 Ensembl ENCODE 500.7 -1.6 -1611 3.5 ZSCAN5C TCF12 POLR2G ZIC2 OSR2 KDM5B FOSL1 ZNF184 FOSL2 RBBP5 NPB ANAPC11 NONHSAG023041.2
GH17J081682 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 -216.6 -216591 3.5 HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 USF1 POLR2G SP1 ARL16 HGS lnc-OXLD1-3 ALYREF CCDC137 PDE6G NPLOC4 TSPAN10 P4HB FOXK2
GH17J082011 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 11.5 +113.3 113347 4.6 POLR2G NCOR1 ZIC2 TCF7 TGIF2 ZBTB7A MXI1 PCBP1 SRSF1 CTCF CENPX ENSG00000260563 TEPSIN ENSG00000262652 ARL2BPP9 OGFOD3 DUS1L NARF-IT1 HEXD FAAP100
GH17J081481 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas 4.9 -417.6 -417648 4.2 EP300 HNRNPK CTCF NRF1 TCF12 MYC USF1 FOS ZIC2 REST LINC01971 ENSG00000265678 FAAP100 CEP131 HGS CCDC57 CHMP6 RFNG CSNK1D HEXD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NPB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NPB

Top Transcription factor binding sites by QIAGEN in the NPB gene promoter:
  • ATF-2
  • MyoD

Genomic Locations for NPB Gene

Genomic Locations for NPB Gene
chr17:81,900,745-81,902,905
(GRCh38/hg38)
Size:
2,161 bases
Orientation:
Plus strand
chr17:79,858,621-79,860,781
(GRCh37/hg19)
Size:
2,161 bases
Orientation:
Plus strand

Genomic View for NPB Gene

Genes around NPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPB Gene

Proteins for NPB Gene

  • Protein details for NPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG41-NPB_HUMAN
    Recommended name:
    Neuropeptide B
    Protein Accession:
    Q8NG41
    Secondary Accessions:
    • A0AUX9
    • A6NJD6
    • B9EJC3

    Protein attributes for NPB Gene

    Size:
    125 amino acids
    Molecular mass:
    13097 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPB Gene

Post-translational modifications for NPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NPB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPB Gene

Domains & Families for NPB Gene

Gene Families for NPB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NPB Gene

Suggested Antigen Peptide Sequences for NPB Gene

GenScript: Design optimal peptide antigens:
  • Preproprotein L7 (NPB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NG41

UniProtKB/Swiss-Prot:

NPB_HUMAN :
  • Belongs to the neuropeptide B/W family.
Family:
  • Belongs to the neuropeptide B/W family.
genes like me logo Genes that share domains with NPB: view

Function for NPB Gene

Molecular function for NPB Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

Gene Ontology (GO) - Molecular Function for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IEA --
GO:0005515 protein binding IPI 12118011
genes like me logo Genes that share ontologies with NPB: view
genes like me logo Genes that share phenotypes with NPB: view

Animal Models for NPB Gene

MGI Knock Outs for NPB:
  • Npb Npb<tm1Ywa>

Animal Model Products

  • Taconic Biosciences Mouse Models for NPB

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPB

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NPB Gene

Localization for NPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NPB gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NPB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NPB Gene

Pathways & Interactions for NPB Gene

genes like me logo Genes that share pathways with NPB: view

Gene Ontology (GO) - Biological Process for NPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IDA,TAS --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NPB: view

No data available for SIGNOR curated interactions for NPB Gene

Drugs & Compounds for NPB Gene

No Compound Related Data Available

Transcripts for NPB Gene

mRNA/cDNA for NPB Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NPB

Alternative Splicing Database (ASD) splice patterns (SP) for NPB Gene

No ASD Table

Relevant External Links for NPB Gene

GeneLoc Exon Structure for
NPB

Expression for NPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NPB Gene

mRNA expression in normal human tissues for NPB Gene

Protein differential expression in normal tissues from HIPED for NPB Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NPB Gene



Protein tissue co-expression partners for NPB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NPB

SOURCE GeneReport for Unigene cluster for NPB Gene:

Hs.708916

mRNA Expression by UniProt/SwissProt for NPB Gene:

Q8NG41-NPB_HUMAN
Tissue specificity: Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hyppocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma.
genes like me logo Genes that share expression patterns with NPB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NPB Gene

Orthologs for NPB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPB Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NPB 31 30
  • 83.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NPB 31 30
  • 81.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Npb 17 31 30
  • 72.85 (n)
rat
(Rattus norvegicus)
Mammalia Npb 30
  • 70.67 (n)
oppossum
(Monodelphis domestica)
Mammalia NPB 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves NPB 31
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NPB 31
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii npb 31
  • 44 (a)
OneToOne
Species where no ortholog for NPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPB Gene

ENSEMBL:
Gene Tree for NPB (if available)
TreeFam:
Gene Tree for NPB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NPB: view image

Paralogs for NPB Gene

Paralogs for NPB Gene

genes like me logo Genes that share paralogs with NPB: view

Variants for NPB Gene

Additional dbSNP identifiers (rs#s) for NPB Gene

Structural Variations from Database of Genomic Variants (DGV) for NPB Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for NPB Gene

Gene Damage Index Score: 1.09; 22.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NPB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NPB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NPB Gene

Disorders for NPB Gene

MalaCards: The human disease database

(5) MalaCards diseases for NPB Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
niemann-pick disease, type b
  • niemann-pick disease, type a
gaucher disease, perinatal lethal
  • gaucher disease, collodion type
niemann-pick disease, type a
  • sphingomyelin lipidosis
niemann-pick disease
  • niemann-pick disease, type a
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search NPB in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPB Gene

Publications for NPB Gene

  1. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. (PMID: 12401809) Brezillon S … Parmentier M (The Journal of biological chemistry 2003) 2 3 4 23 54
  2. Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7. (PMID: 12118011) Fujii R … Fujino M (The Journal of biological chemistry 2002) 2 3 4 54
  3. Development of a potent and selective GPR7 (NPBW1) agonist: a systematic structure-activity study of neuropeptide B. (PMID: 17486669) Kanesaka M … Tokita S (Journal of peptide science : an official publication of the European Peptide Society 2007) 3 23 54
  4. Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. (PMID: 16847439) Singh G … Davenport AP (British journal of pharmacology 2006) 3 23 54
  5. Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects. (PMID: 16273281) Andreis PG … Nussdorfer GG (International journal of molecular medicine 2005) 3 23 54

Products for NPB Gene

Sources for NPB Gene