Aliases for NPAT Gene
External Ids for NPAT Gene
Previous GeneCards Identifiers for NPAT Gene
GeneCards Summary for NPAT Gene
NPAT (Nuclear Protein, Coactivator Of Histone Transcription) is a Protein Coding gene. Diseases associated with NPAT include Ataxia-Telangiectasia and Cleft Palate, Isolated. Among its related pathways are Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and protein C-terminus binding.
UniProtKB/Swiss-Prot Summary for NPAT Gene
Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.