Aliases for NPAS1 Gene
External Ids for NPAS1 Gene
Previous GeneCards Identifiers for NPAS1 Gene
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
GeneCards Summary for NPAS1 Gene
NPAS1 (Neuronal PAS Domain Protein 1) is a Protein Coding gene. Diseases associated with NPAS1 include Basaloid Lung Carcinoma and Schizophrenia. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is NPAS3.
UniProtKB/Swiss-Prot Summary for NPAS1 Gene
May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level (By similarity). Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (By similarity).