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Aliases for NOXRED1 Gene

Aliases for NOXRED1 Gene

  • NADP Dependent Oxidoreductase Domain Containing 1 2 3 5
  • NADP-Dependent Oxidoreductase Domain-Containing Protein 1 3 4
  • Pyrroline-5-Carboxylate Reductase-Like Protein C14orf148 3 4
  • C14orf148 3 4
  • Chromosome 14 Open Reading Frame 148 2
  • EC 1.-.-.- 4

External Ids for NOXRED1 Gene

Previous HGNC Symbols for NOXRED1 Gene

  • C14orf148

Previous GeneCards Identifiers for NOXRED1 Gene

  • GC14M077861

Summaries for NOXRED1 Gene

GeneCards Summary for NOXRED1 Gene

NOXRED1 (NADP Dependent Oxidoreductase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pyrroline-5-carboxylate reductase activity. An important paralog of this gene is PYCR1.

UniProtKB/Swiss-Prot for NOXRED1 Gene

Additional gene information for NOXRED1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOXRED1 Gene

Genomics for NOXRED1 Gene

GeneHancer (GH) Regulatory Elements for NOXRED1 Gene

Promoters and enhancers for NOXRED1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J077157 Enhancer 1 ENCODE dbSUPER 10.1 +267.5 267478 1.1 ZNF473 MCM2 MAFK CREB1 GMEB1 IKZF1 ZBTB33 ZNF600 ZIC2 ZSCAN4 TMEM63C POMT2 ENSG00000201384 NGB NOXRED1 SNW1 ZDHHC22 FAM204DP ENSG00000259164
GH14J077498 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 4.8 -73.0 -72990 1.6 ELF3 MNT TFE3 SP5 GLIS2 RXRB TCF7L2 SP2 TCF7 EZH2 ISM2 SPTLC2 VIPAS39 NOXRED1 GC14M077506
GH14J077561 Enhancer 0.8 Ensembl ENCODE dbSUPER 4.6 -137.1 -137067 2.4 FOS ZNF513 POMT2 GSTZ1 SPTLC2 NOXRED1 RN7SL587P
GH14J077017 Enhancer 0.5 Ensembl dbSUPER 5.2 +407.5 407510 2.2 PRDM10 CIPC LINC01629 NOXRED1 LINC02288 GC14P077023 ENSG00000285966
GH14J077558 Enhancer 0.2 dbSUPER 4.6 -133.6 -133638 1.9 SPTLC2 NOXRED1 RN7SL587P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOXRED1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NOXRED1 Gene

Genomic Locations for NOXRED1 Gene
chr14:77,394,021-77,426,011
(GRCh38/hg38)
Size:
31,991 bases
Orientation:
Minus strand
chr14:77,860,364-77,889,860
(GRCh37/hg19)
Size:
29,497 bases
Orientation:
Minus strand

Genomic View for NOXRED1 Gene

Genes around NOXRED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOXRED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOXRED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOXRED1 Gene

Proteins for NOXRED1 Gene

  • Protein details for NOXRED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXP6-NXRD1_HUMAN
    Recommended name:
    NADP-dependent oxidoreductase domain-containing protein 1
    Protein Accession:
    Q6NXP6
    Secondary Accessions:
    • B3KQ47
    • O95435

    Protein attributes for NOXRED1 Gene

    Size:
    359 amino acids
    Molecular mass:
    39880 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOXRED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOXRED1 Gene

Post-translational modifications for NOXRED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOXRED1 Gene

No data available for DME Specific Peptides for NOXRED1 Gene

Domains & Families for NOXRED1 Gene

Gene Families for NOXRED1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOXRED1 Gene

Suggested Antigen Peptide Sequences for NOXRED1 Gene

GenScript: Design optimal peptide antigens:
  • Pyrroline-5-carboxylate reductase-like protein C14orf148 (CN148_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6NXP6

UniProtKB/Swiss-Prot:

NXRD1_HUMAN :
  • Belongs to the pyrroline-5-carboxylate reductase family.
Family:
  • Belongs to the pyrroline-5-carboxylate reductase family.
genes like me logo Genes that share domains with NOXRED1: view

Function for NOXRED1 Gene

Molecular function for NOXRED1 Gene

UniProtKB/Swiss-Prot Function:
Probable oxidoreductase.

Enzyme Numbers (IUBMB) for NOXRED1 Gene

Phenotypes From GWAS Catalog for NOXRED1 Gene

Gene Ontology (GO) - Molecular Function for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004735 pyrroline-5-carboxylate reductase activity IBA 21873635
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with NOXRED1: view
genes like me logo Genes that share phenotypes with NOXRED1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NOXRED1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOXRED1

Clone Products

  • Applied Biological Materials (abm): Clones for NOXRED1 - Now 50% OFF >
  • * NOXRED1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NOXRED1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NOXRED1 Gene

Localization for NOXRED1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOXRED1 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with NOXRED1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NOXRED1 Gene

Pathways & Interactions for NOXRED1 Gene

PathCards logo

SuperPathways for NOXRED1 Gene

No Data Available

Interacting Proteins for NOXRED1 Gene

Gene Ontology (GO) - Biological Process for NOXRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
GO:0055129 L-proline biosynthetic process IBA 21873635
genes like me logo Genes that share ontologies with NOXRED1: view

No data available for Pathways by source and SIGNOR curated interactions for NOXRED1 Gene

Drugs & Compounds for NOXRED1 Gene

No Compound Related Data Available

Transcripts for NOXRED1 Gene

mRNA/cDNA for NOXRED1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NOXRED1 Gene

NADP-dependent oxidoreductase domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOXRED1

Clone Products

  • Applied Biological Materials (abm): Clones for NOXRED1 - Now 50% OFF >
  • * NOXRED1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NOXRED1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NOXRED1 Gene

No ASD Table

Relevant External Links for NOXRED1 Gene

GeneLoc Exon Structure for
NOXRED1
ECgene alternative splicing isoforms for
NOXRED1

Expression for NOXRED1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOXRED1 Gene

mRNA differential expression in normal tissues according to GTEx for NOXRED1 Gene

This gene is overexpressed in Testis (x12.1).

Protein differential expression in normal tissues from HIPED for NOXRED1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NOXRED1 Gene



Protein tissue co-expression partners for NOXRED1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOXRED1 Gene:

NOXRED1

SOURCE GeneReport for Unigene cluster for NOXRED1 Gene:

Hs.97556
genes like me logo Genes that share expression patterns with NOXRED1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOXRED1 Gene

Orthologs for NOXRED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXRED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOXRED1 35 34
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NOXRED1 35 34
  • 82.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NOXRED1 35 34
  • 77.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Noxred1 17 35 34
  • 73.11 (n)
rat
(Rattus norvegicus)
Mammalia Noxred1 34
  • 72.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOXRED1 35
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOXRED1 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOXRED1 35 34
  • 59.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOXRED1 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noxred1 34
  • 51.72 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884934 34
  • 50.46 (n)
NOXRED1 35
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for NOXRED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOXRED1 Gene

ENSEMBL:
Gene Tree for NOXRED1 (if available)
TreeFam:
Gene Tree for NOXRED1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOXRED1: view image

Paralogs for NOXRED1 Gene

Paralogs for NOXRED1 Gene

genes like me logo Genes that share paralogs with NOXRED1: view

Variants for NOXRED1 Gene

Sequence variations from dbSNP and Humsavar for NOXRED1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000003882 -- 77,424,840(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000067040 -- 77,401,625(-) G/A intron_variant
rs1000086100 -- 77,417,214(-) C/A intron_variant
rs1000333577 -- 77,401,273(-) G/C intron_variant
rs1000493967 -- 77,398,636(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOXRED1 Gene

Variant ID Type Subtype PubMed ID
nsv1041985 CNV loss 25217958
nsv1362 CNV deletion 18451855
nsv85801 CNV deletion 16902084

Variation tolerance for NOXRED1 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOXRED1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOXRED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOXRED1 Gene

Disorders for NOXRED1 Gene

Additional Disease Information for NOXRED1

No disorders were found for NOXRED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOXRED1 Gene

Publications for NOXRED1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for NOXRED1 Gene

Sources for NOXRED1 Gene

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