NOXA1 Gene (Protein Coding)

NADPH Oxidase Activator 1

GC09P137423
GIFtS:
37
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple tr... See more...

Aliases for NOXA1 Gene

Aliases for NOXA1 Gene

  • NADPH Oxidase Activator 1 2 3 4 5
  • Serologically Defined Colon Cancer Antigen 31 2 3
  • P67phox-Like Factor 3 4
  • NCF2-Like Protein 3 4
  • Antigen NY-CO-31 3 4
  • NY-CO-31 2 3
  • P51-Nox 3 4
  • P51NOX 3 4
  • Inhibitory NADPH Oxidase Activator 1 3
  • Nox Activator 1 3
  • NOX Activator 1 4
  • SDCCAG31 3
  • FLJ25475 2
  • NOXA1 5

External Ids for NOXA1 Gene

Previous HGNC Symbols for NOXA1 Gene

  • SDCCAG31

Previous GeneCards Identifiers for NOXA1 Gene

  • GC00U905127
  • GC09U900274
  • GC09P9B0117
  • GC09P137593
  • GC09P139437
  • GC09P140317
  • GC09P109781

Summaries for NOXA1 Gene

Entrez Gene Summary for NOXA1 Gene

  • This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for NOXA1 Gene

NOXA1 (NADPH Oxidase Activator 1) is a Protein Coding gene. Diseases associated with NOXA1 include Lung Mucoepidermoid Carcinoma and Cardiomyopathy, Familial Hypertrophic, 2. Among its related pathways are Signaling by GPCR and RHO GTPases Activate NADPH Oxidases. Gene Ontology (GO) annotations related to this gene include enzyme binding and Rac GTPase binding. An important paralog of this gene is NCF2.

UniProtKB/Swiss-Prot Summary for NOXA1 Gene

  • Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Gene Wiki entry for NOXA1 Gene

Additional gene information for NOXA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOXA1 Gene

Genomics for NOXA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NOXA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J137422 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 619.9 +0.1 129 3.8 SP1 HNRNPL GATAD2A PRDM10 ZNF629 SIX5 IKZF1 CTCF ZNF692 BACH1 NOXA1 EXD3 lnc-ENTPD8-2 NPDC1 AJM1 CACNA1B HSALNG0075422 ENTPD8
GH09J137453 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.5 +31.0 30999 2.8 HNRNPL GATAD2A TFE3 IKZF1 NFKBIZ RCOR2 PHF21A RBFOX2 RXRB PATZ1 NOXA1 NSMF MIR7114 ENTPD8
GH09J137309 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.1 -109.9 -109948 8 SP1 CREB1 ZBTB33 ZNF629 ZNF692 BACH1 TARDBP ZHX2 JUND LARP7 EXD3 NOXA1 INPP5E NPDC1 NRARP PNPLA7 lnc-NRARP-2
GH09J137441 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 14.1 +18.4 18367 1 HNRNPL GATAD2A TFE3 ZNF692 TARDBP ZIC2 RBFOX2 RXRB PATZ1 SP1 ENTPD8 NOXA1 HSALNG0075422
GH09J137435 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.7 +12.5 12451 3.6 HNRNPL GATAD2A JUND FOXA1 MTA2 ZIC2 PATZ1 REST DPF2 HDAC1 NOXA1 HSALNG0075422 ENTPD8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOXA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOXA1

Top Transcription factor binding sites by QIAGEN in the NOXA1 gene promoter:
  • AP-1
  • AP-4
  • ATF-2
  • c-Fos
  • c-Jun
  • c-Myb
  • E47
  • Hand1

Genomic Locations for NOXA1 Gene

Genomic Locations for NOXA1 Gene
chr9:137,423,350-137,434,406
(GRCh38/hg38)
Size:
11,057 bases
Orientation:
Plus strand
chr9:140,317,802-140,328,858
(GRCh37/hg19)
Size:
11,057 bases
Orientation:
Plus strand

Genomic View for NOXA1 Gene

Genes around NOXA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOXA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOXA1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NOXA1 Gene

Proteins for NOXA1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NOXA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UR1-NOXA1_HUMAN
    Recommended name:
    NADPH oxidase activator 1
    Protein Accession:
    Q86UR1
    Secondary Accessions:
    • O60533
    • Q29VU9
    • Q29VV0
    • Q2TAM1
    • Q8IUS3

    Protein attributes for NOXA1 Gene

    Size:
    476 amino acids
    Molecular mass:
    50933 Da
    Quaternary structure:
    • NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct.
    SequenceCaution:
    • Sequence=AAY16126.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Mostly inactive for NOX1 activation. Does not interact with NOXO1.
    • [Isoform 3]: Inactive for NOX1 activation.

    Alternative splice isoforms for NOXA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOXA1 Gene

Protein Expression for NOXA1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NOXA1 Gene

Other Protein References for NOXA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NOXA1
  • Boster Bio Antibodies for NOXA1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NOXA1

No data available for DME Specific Peptides for NOXA1 Gene

Domains & Families for NOXA1 Gene

Gene Families for NOXA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOXA1 Gene

InterPro:
Blocks:
  • SH3 domain signature
ProtoNet:

Suggested Antigen Peptide Sequences for NOXA1 Gene

GenScript: Design optimal peptide antigens:
  • p51-nox (NOXA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UR1

UniProtKB/Swiss-Prot:

NOXA1_HUMAN :
  • The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.
  • Belongs to the NCF2/NOXA1 family.
Domain:
  • The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function.
  • The TPR repeats mediate interaction with RAC1.
Family:
  • Belongs to the NCF2/NOXA1 family.
genes like me logo Genes that share domains with NOXA1: view

Function for NOXA1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NOXA1 Gene

UniProtKB/Swiss-Prot Function:
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.

Phenotypes From GWAS Catalog for NOXA1 Gene

Gene Ontology (GO) - Molecular Function for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16636067
GO:0016176 superoxide-generating NADPH oxidase activator activity IMP 16636067
GO:0017124 SH3 domain binding IPI 19755710
GO:0019899 enzyme binding IPI 16636067
GO:0048365 Rac GTPase binding IPI 16636067
genes like me logo Genes that share ontologies with NOXA1: view
genes like me logo Genes that share phenotypes with NOXA1: view

Animal Models for NOXA1 Gene

MGI Knock Outs for NOXA1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOXA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NOXA1 Gene

Localization for NOXA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOXA1 Gene

Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOXA1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0043020 NADPH oxidase complex IDA 16636067
genes like me logo Genes that share ontologies with NOXA1: view

Pathways & Interactions for NOXA1 Gene

genes like me logo Genes that share pathways with NOXA1: view

Pathways by source for NOXA1 Gene

1 GeneGo (Thomson Reuters) pathway for NOXA1 Gene
  • G-protein signaling_Rac2 regulation pathway

SIGNOR curated interactions for NOXA1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NOXA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IMP 20609497
GO:0010310 regulation of hydrogen peroxide metabolic process IMP 16636067
GO:0042554 superoxide anion generation IBA 21873635
GO:0043085 positive regulation of catalytic activity IEA --
GO:0060263 regulation of respiratory burst IMP 16636067
genes like me logo Genes that share ontologies with NOXA1: view

Drugs & Compounds for NOXA1 Gene

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  1. Drug

(3) Drugs for NOXA1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrogen peroxide Approved, Vet_approved Pharma 115
NADPH Experimental Pharma 0

(1) Additional Compounds for NOXA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NOXA1: view

Transcripts for NOXA1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NOXA1 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOXA1

Alternative Splicing Database (ASD) splice patterns (SP) for NOXA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -

Relevant External Links for NOXA1 Gene

GeneLoc Exon Structure for
NOXA1

Expression for NOXA1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOXA1 Gene

mRNA expression in normal human tissues for NOXA1 Gene
mRNA expression by GTEx for NOXA1 Gene

Protein differential expression in normal tissues from HIPED for NOXA1 Gene

This gene is overexpressed in Cerebrospinal fluid (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NOXA1 Gene



Protein tissue co-expression partners for NOXA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOXA1

SOURCE GeneReport for Unigene cluster for NOXA1 Gene:

Hs.495554

mRNA Expression by UniProt/SwissProt for NOXA1 Gene:

Q86UR1-NOXA1_HUMAN
Tissue specificity: Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.

Evidence on tissue expression from TISSUES for NOXA1 Gene

  • Kidney(4.5)
  • Intestine(4.4)
  • Nervous system(4.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with NOXA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOXA1 Gene

Orthologs for NOXA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOXA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NOXA1 30 31
  • 99.16 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NOXA1 30 31
  • 83.93 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NOXA1 30 31
  • 82.47 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Noxa1 30 17 31
  • 72.28 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Noxa1 30
  • 69.98 (n)
Oppossum
(Monodelphis domestica)
 Mammalia NOXA1 31
  • 53 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia NOXA1 31
  • 41 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NOXA1 30 31
  • 59.58 (n)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia noxa1 30
  • 55.65 (n)
Zebrafish
(Danio rerio)
 Actinopterygii noxa1 31
  • 32 (a)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 18 (a)
 OneToMany
Species where no ortholog for NOXA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NOXA1 Gene

ENSEMBL:
Gene Tree for NOXA1 (if available)
TreeFam:
Gene Tree for NOXA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOXA1: view image

Paralogs for NOXA1 Gene

Paralogs for NOXA1 Gene

genes like me logo Genes that share paralogs with NOXA1: view

Variants for NOXA1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOXA1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs773184989 Not Provided: not provided 137,433,217(+) T/TG FRAMESHIFT_VARIANT
rs34155071 - p.Pro286Leu

Additional dbSNP identifiers (rs#s) for NOXA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NOXA1 Gene

Variant ID Type Subtype PubMed ID
esv2675903 CNV deletion 23128226
esv2759721 CNV loss 17122850
esv3573431 CNV loss 25503493
esv3622034 CNV gain 21293372
nsv1049808 CNV gain 25217958
nsv1075290 CNV deletion 25765185
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv6771 CNV insertion 18451855
nsv951208 CNV deletion 24416366

Variation tolerance for NOXA1 Gene

Gene Damage Index Score: 5.35; 70.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOXA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOXA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOXA1 Gene

Disorders for NOXA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOXA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lung mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of lung
cardiomyopathy, familial hypertrophic, 2
  • cmh2
- elite association - COSMIC cancer census association via MalaCards
Search NOXA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOXA1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NOXA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOXA1 Gene

Publications for NOXA1 Gene

  1. Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding. (PMID: 17913709) Kim JS … Bokoch GM (The Journal of biological chemistry 2007) 3 4 23
  2. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. (PMID: 12716910) Takeya R … Sumimoto H (The Journal of biological chemistry 2003) 3 4 23
  3. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan MJ … Old LJ (International journal of cancer 1998) 2 3 4
  4. Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation. (PMID: 20609497) Gianni D … Bokoch GM (European journal of cell biology 2011) 3 4
  5. Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1. (PMID: 20454568) Dutta S … Rittinger K (PloS one 2010) 3 23

ExternalLinks

View latest publications for NOXA1 gene in Mastermind

Products for NOXA1 Gene

  • Addgene plasmids for NOXA1

Sources for NOXA1 Gene