Aliases for NOXA1 Gene
External Ids for NOXA1 Gene
Previous HGNC Symbols for NOXA1 Gene
Previous GeneCards Identifiers for NOXA1 Gene
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for NOXA1 Gene
NOXA1 (NADPH Oxidase Activator 1) is a Protein Coding gene. Diseases associated with NOXA1 include Lung Mucoepidermoid Carcinoma and Cardiomyopathy, Familial Hypertrophic, 2. Among its related pathways are Signaling by GPCR and RHO GTPases Activate NADPH Oxidases. Gene Ontology (GO) annotations related to this gene include enzyme binding and Rac GTPase binding. An important paralog of this gene is NCF2.
UniProtKB/Swiss-Prot Summary for NOXA1 Gene
Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.