Aliases for NOX5 Gene
External Ids for NOX5 Gene
Previous GeneCards Identifiers for NOX5 Gene
This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for NOX5 Gene
NOX5 (NADPH Oxidase 5) is a Protein Coding gene. Diseases associated with NOX5 include Chronic Granulomatous Disease and Cardiomyopathy, Familial Hypertrophic, 2. Among its related pathways are Detoxification of Reactive Oxygen Species and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include calcium ion binding and heme binding. An important paralog of this gene is DUOX1.
UniProtKB/Swiss-Prot Summary for NOX5 Gene
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.