This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signa... See more...

Aliases for NOX3 Gene

Aliases for NOX3 Gene

  • NADPH Oxidase 3 2 3 4 5
  • GP91-3 2 3 4
  • Mitogenic Oxidase 2 3 4
  • Gp91phox Homolog 3 3 4
  • MOX-2 3 4
  • NADPH Oxidase Catalytic Subunit-Like 3 3
  • EC 1.6.3.- 4
  • EC 1.6.3 50
  • NOX3 5
  • MOX2 4

External Ids for NOX3 Gene

Previous GeneCards Identifiers for NOX3 Gene

  • GC06M155277
  • GC06M155611
  • GC06M155747
  • GC06M155808
  • GC06M153278
  • GC06M155716

Summaries for NOX3 Gene

Entrez Gene Summary for NOX3 Gene

  • This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]

GeneCards Summary for NOX3 Gene

NOX3 (NADPH Oxidase 3) is a Protein Coding gene. Diseases associated with NOX3 include Drug-Induced Hearing Loss and Lung Mucoepidermoid Carcinoma. Among its related pathways are Signaling by GPCR and RHO GTPases Activate NADPH Oxidases. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and superoxide-generating NADPH oxidase activity. An important paralog of this gene is CYBB.

UniProtKB/Swiss-Prot Summary for NOX3 Gene

  • NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.

Gene Wiki entry for NOX3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOX3 Gene

Genomics for NOX3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NOX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J155455 Enhancer 0.3 Ensembl 250.7 -0.1 -62 0.6 PRDM10 SCRT2 NOX3 piR-38051-251
GH06J155399 Enhancer 1.3 FANTOM5 Ensembl dbSUPER 10.3 +56.5 56499 1.1 SSRP1 KLF9 CEBPA CHD4 MXD4 KLF11 CHD2 ZFP64 HOMEZ KMT2B SCAF8 NOX3 TFB1M HSALNG0054511 lnc-TFB1M-3
GH06J155417 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.4 +37.3 37291 2.1 ZNF207 ZBTB10 EBF1 CBFB MYNN BHLHE40 SPI1 BATF ELF1 IKZF1 NOX3 CLDN20 lnc-TFB1M-3 HSALNG0054511 TFB1M
GH06J155485 Enhancer 0.9 ENCODE 11.6 -30.7 -30713 1.2 CEBPA CHD4 FOXA1 KLF11 ZFP64 HOMEZ KMT2B THAP11 FOXA2 KDM6A NOX3 HSALNG0054514 HSALNG0054515 LOC105378068
GH06J155340 Enhancer 0.9 Ensembl ENCODE 9.4 +114.5 114538 1.8 CTCF TEAD3 CBFB RAD21 BCL6 ZNF205 ELF3 IKZF5 RXRB ZNF217 TFB1M NOX3 HSALNG0054508 HSALNG0054507
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOX3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOX3

Top Transcription factor binding sites by QIAGEN in the NOX3 gene promoter:
  • Chx10
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • RORalpha1
  • TBP
  • TFIID

Genomic Locations for NOX3 Gene

Latest Assembly
chr6:155,395,368-155,455,839
(GRCh38/hg38)
Size:
60,472 bases
Orientation:
Minus strand

Previous Assembly
chr6:155,716,502-155,776,973
(GRCh37/hg19 by Entrez Gene)
Size:
60,472 bases
Orientation:
Minus strand

chr6:155,716,504-155,777,037
(GRCh37/hg19 by Ensembl)
Size:
60,534 bases
Orientation:
Minus strand

Genomic View for NOX3 Gene

Genes around NOX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOX3 Gene

Proteins for NOX3 Gene

  • Protein details for NOX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBY0-NOX3_HUMAN
    Recommended name:
    NADPH oxidase 3
    Protein Accession:
    Q9HBY0
    Secondary Accessions:
    • Q9HBJ9

    Protein attributes for NOX3 Gene

    Size:
    568 amino acids
    Molecular mass:
    64935 Da
    Quaternary structure:
    • Interacts with and stabilizes CYBA/p22phox.

neXtProt entry for NOX3 Gene

Selected DME Specific Peptides for NOX3 Gene

Q9HBY0:
  • LEWHPFTLTSAP
  • CLNFNCMLIL
  • AFEWFADLL
  • ARASALCLNFN
  • GIGVTPF

Post-translational modifications for NOX3 Gene

  • Glycosylation at Asn163 and Asn238
  • Modification sites at PhosphoSitePlus

Other Protein References for NOX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NOX3 Gene

Gene Families for NOX3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for NOX3 Gene

InterPro:
Blocks:
  • Cytochrome B-245 heavy chain signature
  • Ferric reductase-like transmembrane component, N-terminal

Suggested Antigen Peptide Sequences for NOX3 Gene

GenScript: Design optimal peptide antigens:
  • gp91phox homolog 3 (NOX3_HUMAN)
genes like me logo Genes that share domains with NOX3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NOX3 Gene

Function for NOX3 Gene

Molecular function for NOX3 Gene

UniProtKB/Swiss-Prot Function:
NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the ototoxic drug cisplatin (By similarity). Activated by NOXO1. Cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. Inhibited by diphenyleneiodonium chloride.

Enzyme Numbers (IUBMB) for NOX3 Gene

Phenotypes From GWAS Catalog for NOX3 Gene

Gene Ontology (GO) - Molecular Function for NOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0016175 superoxide-generating NADPH oxidase activity IBA 21873635
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with NOX3: view
genes like me logo Genes that share phenotypes with NOX3: view

miRNA for NOX3 Gene

miRTarBase miRNAs that target NOX3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOX3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOX3 Gene

Localization for NOX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOX3 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOX3 gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043020 NADPH oxidase complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with NOX3: view

Pathways & Interactions for NOX3 Gene

PathCards logo

SuperPathways for NOX3 Gene

SuperPathway Contained pathways
1 Signaling by Rho GTPases
2 PAK Pathway
.56
3 Apoptotic Pathways in Synovial Fibroblasts
.65
4 Integrin Pathway
.38
5 RHO GTPases Activate NADPH Oxidases
genes like me logo Genes that share pathways with NOX3: view

Pathways by source for NOX3 Gene

3 Qiagen pathways for NOX3 Gene
  • Antioxidant Action of Vitamin-C
  • Rac1 Pathway
  • Transendothelial Migration of Leukocytes

Gene Ontology (GO) - Biological Process for NOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0006952 defense response IBA 21873635
GO:0009590 detection of gravity IEA --
GO:0009629 response to gravity IEA --
GO:0042554 superoxide anion generation IBA 21873635
genes like me logo Genes that share ontologies with NOX3: view

No data available for SIGNOR curated interactions for NOX3 Gene

Drugs & Compounds for NOX3 Gene

(3) Drugs for NOX3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
NADPH Experimental Pharma 0
Chloride ion Experimental Pharma 0
genes like me logo Genes that share compounds with NOX3: view

Transcripts for NOX3 Gene

mRNA/cDNA for NOX3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOX3

Alternative Splicing Database (ASD) splice patterns (SP) for NOX3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2:

Relevant External Links for NOX3 Gene

GeneLoc Exon Structure for
NOX3

Expression for NOX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOX3 Gene

mRNA differential expression in normal tissues according to GTEx for NOX3 Gene

This gene is overexpressed in Brain - Hippocampus (x10.7), Brain - Anterior cingulate cortex (BA24) (x5.1), and Brain - Frontal Cortex (BA9) (x4.9).

Protein differential expression in normal tissues from HIPED for NOX3 Gene

This gene is overexpressed in Adipocyte (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NOX3 Gene



Protein tissue co-expression partners for NOX3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOX3

SOURCE GeneReport for Unigene cluster for NOX3 Gene:

Hs.247776

Evidence on tissue expression from TISSUES for NOX3 Gene

  • Blood(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with NOX3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOX3 Gene

Orthologs for NOX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOX3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NOX3 29 30
  • 99.06 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NOX3 29 30
  • 86.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NOX3 29 30
  • 86.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nox3 29
  • 81.28 (n)
Mouse
(Mus musculus)
Mammalia Nox3 29 16 30
  • 80.93 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NOX3 30
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 73 (a)
OneToMany
-- 30
  • 73 (a)
OneToMany
-- 30
  • 69 (a)
OneToMany
Chicken
(Gallus gallus)
Aves NOX3 29 30
  • 73.37 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NOX3 30
  • 69 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CABZ01082570.1 30
  • 33 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 48 (a)
OneToMany
Species where no ortholog for NOX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NOX3 Gene

ENSEMBL:
Gene Tree for NOX3 (if available)
TreeFam:
Gene Tree for NOX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOX3: view image
Alliance of Genome Resources:
Additional Orthologs for NOX3

Paralogs for NOX3 Gene

Paralogs for NOX3 Gene

(5) SIMAP similar genes for NOX3 Gene using alignment to 1 proteins:

  • NOX3_HUMAN
genes like me logo Genes that share paralogs with NOX3: view

Variants for NOX3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOX3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs9480130 Benign: not provided 155,396,950(-) G/A
NM_015718.3(NOX3):c.1593C>T (p.Gly531=)
SYNONYMOUS
rs3749930 -- p.Thr171Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NOX3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NOX3 Gene

Variant ID Type Subtype PubMed ID
esv33329 CNV loss 17666407
nsv1025003 CNV gain 25217958
nsv1133386 CNV tandem duplication 24896259
nsv525807 CNV loss 19592680
nsv5553 CNV deletion 18451855

Variation tolerance for NOX3 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.54; 92.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOX3
Leiden Open Variation Database (LOVD)
NOX3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOX3 Gene

Disorders for NOX3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NOX3 Gene - From: COP

Disorder Aliases PubMed IDs
drug-induced hearing loss
  • drug induced hearing loss
lung mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of lung
phagocyte bactericidal dysfunction
  • phagocytic dysfunction
- elite association - COSMIC cancer census association via MalaCards
Search NOX3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOX3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NOX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOX3 Gene

Publications for NOX3 Gene

  1. Nox3 regulation by NOXO1, p47phox, and p67phox. (PMID: 15181005) Cheng G … Lambeth JD (The Journal of biological chemistry 2004) 3 4 22
  2. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. (PMID: 11376945) Cheng G … Lambeth JD (Gene 2001) 2 3 4
  3. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 40
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  5. Genes to diseases (G2D) computational method to identify asthma candidate genes. (PMID: 18682798) Tremblay K … Laprise C (PloS one 2008) 3 40

Products for NOX3 Gene

Sources for NOX3 Gene