Aliases for NOX3 Gene
External Ids for NOX3 Gene
Previous GeneCards Identifiers for NOX3 Gene
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]
GeneCards Summary for NOX3 Gene
NOX3 (NADPH Oxidase 3) is a Protein Coding gene. Diseases associated with NOX3 include Drug-Induced Hearing Loss and Lung Mucoepidermoid Carcinoma. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and superoxide-generating NADPH oxidase activity. An important paralog of this gene is CYBB.
UniProtKB/Swiss-Prot Summary for NOX3 Gene
NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.