Aliases for NOX1 Gene
External Ids for NOX1 Gene
Previous GeneCards Identifiers for NOX1 Gene
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
GeneCards Summary for NOX1 Gene
NOX1 (NADPH Oxidase 1) is a Protein Coding gene. Diseases associated with NOX1 include Chronic Granulomatous Disease and Inflammatory Bowel Disease. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and Rac GTPase binding. An important paralog of this gene is CYBB.
UniProtKB/Swiss-Prot Summary for NOX1 Gene
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS).