This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms ha... See more...

Aliases for NOVA1 Gene

Aliases for NOVA1 Gene

  • NOVA Alternative Splicing Regulator 1 2 3 5
  • Neuro-Oncological Ventral Antigen 1 2 3 4
  • Ventral Neuron-Specific Protein 1 3 4
  • Onconeural Ventral Antigen 1 3 4
  • RNA-Binding Protein Nova-1 3 4
  • Paraneoplastic Ri Antigen 3 4
  • Nova-1 3

External Ids for NOVA1 Gene

Previous GeneCards Identifiers for NOVA1 Gene

  • GC14M024286
  • GC14M020702
  • GC14M024905
  • GC14M025984
  • GC14M026915
  • GC14M007031

Summaries for NOVA1 Gene

Entrez Gene Summary for NOVA1 Gene

  • This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOVA1 Gene

NOVA1 (NOVA Alternative Splicing Regulator 1) is a Protein Coding gene. Diseases associated with NOVA1 include Partial Fetal Alcohol Syndrome and Low-Grade Astrocytoma. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is NOVA2.

UniProtKB/Swiss-Prot Summary for NOVA1 Gene

  • May regulate RNA splicing or metabolism in a specific subset of developing neurons.

Gene Wiki entry for NOVA1 Gene

Additional gene information for NOVA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOVA1 Gene

Genomics for NOVA1 Gene

GeneHancer (GH) Regulatory Elements for NOVA1 Gene

Promoters and enhancers for NOVA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J026595 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 505.8 +2.6 2632 8.4 ZNF217 EP300 PHF8 ZBTB10 ZBTB26 SAP30 GATAD2B HDAC2 CTBP1 ZNF341 NOVA1 ENSG00000262119 lnc-STXBP6-5 LINC02588 LINC02293 lnc-NOVA1-6
GH14J026553 Enhancer 0.4 Ensembl 11.5 +44.0 44032 1.6 ATF2 CREB1 JUND JUN ATF7 NOVA1 LINC02293 piR-48749-008 piR-38580-084 lnc-STXBP6-5 lnc-NOVA1-6
GH14J026561 Enhancer 0.3 Ensembl 16.4 +36.8 36832 0.4 POLR2A NOVA1 piR-48749-008 piR-38580-084 lnc-STXBP6-5 lnc-NOVA1-6
GH14J026565 Enhancer 0.3 Ensembl 11.7 +32.6 32632 0.8 CREB1 TRIM22 piR-48749-008 NOVA1 LINC02293 lnc-STXBP6-5 piR-38580-084 lnc-NOVA1-6
GH14J026622 Enhancer 0.3 ENCODE 12.1 -24.4 -24375 1.6 EZH2 NOVA1 piR-61532-100 piR-52294-048 ENSG00000258081 LINC02588 lnc-NOVA1-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOVA1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOVA1

Top Transcription factor binding sites by QIAGEN in the NOVA1 gene promoter:
  • C/EBPalpha
  • FAC1
  • Lhx3a
  • LHX3b
  • NRSF form 1
  • NRSF form 2

Genomic Locations for NOVA1 Gene

Genomic Locations for NOVA1 Gene
chr14:26,443,090-26,598,033
(GRCh38/hg38)
Size:
154,944 bases
Orientation:
Minus strand
chr14:26,912,299-27,066,960
(GRCh37/hg19)
Size:
154,662 bases
Orientation:
Minus strand

Genomic View for NOVA1 Gene

Genes around NOVA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOVA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOVA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOVA1 Gene

Proteins for NOVA1 Gene

  • Protein details for NOVA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51513-NOVA1_HUMAN
    Recommended name:
    RNA-binding protein Nova-1
    Protein Accession:
    P51513
    Secondary Accessions:
    • A8K0S4
    • A8K4Q7
    • D3DS81
    • D3DS82
    • Q6B004

    Protein attributes for NOVA1 Gene

    Size:
    507 amino acids
    Molecular mass:
    51727 Da
    Quaternary structure:
    • Interacts with PTBP2; the interaction is direct.
    SequenceCaution:
    • Sequence=AAA16022.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact leading to an insertion into the sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NOVA1 Gene

    Alternative splice isoforms for NOVA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOVA1 Gene

Post-translational modifications for NOVA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOVA1 Gene

Domains & Families for NOVA1 Gene

Gene Families for NOVA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOVA1 Gene

Blocks:
  • KH domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOVA1 Gene

GenScript: Design optimal peptide antigens:
  • Ventral neuron-specific protein 1 (NOVA1_HUMAN)
genes like me logo Genes that share domains with NOVA1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NOVA1 Gene

Function for NOVA1 Gene

Molecular function for NOVA1 Gene

UniProtKB/Swiss-Prot Function:
May regulate RNA splicing or metabolism in a specific subset of developing neurons.
GENATLAS Biochemistry:
neuro-oncological ventral antigen 1 identified using antisera from patients with breast,and with a paraneoplastic neurologic disorder cancer,involving subcortical motor system characterized by paraneoplastic opsoclonus myoclonus ataxia

Phenotypes From GWAS Catalog for NOVA1 Gene

Gene Ontology (GO) - Molecular Function for NOVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22681889
GO:0003729 mRNA binding IEA --
GO:0003730 mRNA 3'-UTR binding IEA --
GO:0005515 protein binding IPI 27733149
genes like me logo Genes that share ontologies with NOVA1: view
genes like me logo Genes that share phenotypes with NOVA1: view

Animal Models for NOVA1 Gene

MGI Knock Outs for NOVA1:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for NOVA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOVA1 Gene

Localization for NOVA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOVA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOVA1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with NOVA1: view

Pathways & Interactions for NOVA1 Gene

PathCards logo

SuperPathways for NOVA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IEA --
GO:0006396 RNA processing TAS 8398153
GO:0007268 chemical synaptic transmission TAS 8558240
GO:0007626 locomotory behavior TAS 8558240
GO:0008380 RNA splicing TAS 8398153
genes like me logo Genes that share ontologies with NOVA1: view

No data available for Pathways by source and SIGNOR curated interactions for NOVA1 Gene

Drugs & Compounds for NOVA1 Gene

No Compound Related Data Available

Transcripts for NOVA1 Gene

mRNA/cDNA for NOVA1 Gene

12 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NOVA1

Alternative Splicing Database (ASD) splice patterns (SP) for NOVA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for NOVA1 Gene

GeneLoc Exon Structure for
NOVA1

Expression for NOVA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOVA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOVA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.6) and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for NOVA1 Gene

This gene is overexpressed in Fetal Brain (43.1) and Frontal cortex (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOVA1 Gene



Protein tissue co-expression partners for NOVA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOVA1

SOURCE GeneReport for Unigene cluster for NOVA1 Gene:

Hs.31588

mRNA Expression by UniProt/SwissProt for NOVA1 Gene:

P51513-NOVA1_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for NOVA1 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NOVA1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NOVA1 Gene

Orthologs for NOVA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOVA1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NOVA1 31
  • 100 (a)
OneToOne
LOC490632 30
  • 98.76 (n)
cow
(Bos Taurus)
Mammalia NOVA1 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOVA1 31 30
  • 99.79 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOVA1 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nova1 17 31 30
  • 96.55 (n)
rat
(Rattus norvegicus)
Mammalia Nova1 30
  • 96.13 (n)
oppossum
(Monodelphis domestica)
Mammalia NOVA1 31
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOVA1 31 30
  • 95.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOVA1 31
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nova1 30
  • 80.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53786 30
zebrafish
(Danio rerio)
Actinopterygii nova2 31 30
  • 70.67 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ps 31 32
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y59A8B.10 31
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 31
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BTR1L 30
  • 49.01 (n)
rice
(Oryza sativa)
Liliopsida Os02g0822300 30
  • 51.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToMany
Species where no ortholog for NOVA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOVA1 Gene

ENSEMBL:
Gene Tree for NOVA1 (if available)
TreeFam:
Gene Tree for NOVA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOVA1: view image

Paralogs for NOVA1 Gene

(13) SIMAP similar genes for NOVA1 Gene using alignment to 10 proteins:

  • NOVA1_HUMAN
  • B7Z770_HUMAN
  • F8VW64_HUMAN
  • F8VWX1_HUMAN
  • F8VYI3_HUMAN
  • F8W659_HUMAN
  • G8JLA5_HUMAN
  • H0YHZ1_HUMAN
  • I3L2B5_HUMAN
  • J3KQU3_HUMAN
genes like me logo Genes that share paralogs with NOVA1: view

Variants for NOVA1 Gene

Additional dbSNP identifiers (rs#s) for NOVA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NOVA1 Gene

Variant ID Type Subtype PubMed ID
esv3306654 CNV mobile element insertion 20981092
esv3308915 CNV mobile element insertion 20981092
esv3364490 CNV insertion 20981092
esv3426721 CNV insertion 20981092
esv3633850 CNV gain 21293372
esv3633851 CNV loss 21293372
nsv1052199 CNV loss 25217958
nsv564106 CNV loss 21841781
nsv564107 CNV loss 21841781
nsv85659 CNV deletion 16902084
nsv952820 CNV deletion 24416366

Variation tolerance for NOVA1 Gene

Residual Variation Intolerance Score: 9.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOVA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOVA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOVA1 Gene

Disorders for NOVA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NOVA1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
partial fetal alcohol syndrome
low-grade astrocytoma
gait apraxia
oligodendroglioma
  • oligodendroglial neoplasm
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search NOVA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOVA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NOVA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOVA1 Gene

Publications for NOVA1 Gene

  1. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. (PMID: 8398153) Buckanovich RJ … Darnell RB (Neuron 1993) 3 4 23 54
  2. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan RS … Blankenberg S (JAMA 2009) 3 41 54
  3. Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients. (PMID: 19680635) Alkelai A … Lerer B (Psychopharmacology 2009) 3 41 54
  4. Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. (PMID: 18218628) Ratti A … Silani V (The Journal of biological chemistry 2008) 3 23 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for NOVA1 Gene

Sources for NOVA1 Gene