Aliases for NOTUM Gene

Aliases for NOTUM Gene

  • Notum, Palmitoleoyl-Protein Carboxylesterase 2 3 5
  • [Wnt Protein] O-Palmitoleoyl-L-Serine Hydrolase 2 3
  • Palmitoleoyl-Protein Carboxylesterase NOTUM 3 4
  • HNOTUM 3 4
  • Notum Pectinacetylesterase Homolog (Drosophila) 2
  • Notum Pectinacetylesterase Homolog 3
  • Protein Notum Homolog 3
  • EC 3.1.1.98 4

External Ids for NOTUM Gene

Previous GeneCards Identifiers for NOTUM Gene

  • GC17M077504
  • GC17M079910
  • GC17M075311

Summaries for NOTUM Gene

GeneCards Summary for NOTUM Gene

NOTUM (Notum, Palmitoleoyl-Protein Carboxylesterase) is a Protein Coding gene. Diseases associated with NOTUM include Suppurative Periapical Periodontitis and Retinitis Pigmentosa 49. Among its related pathways are Signaling by GPCR and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include hydrolase activity and palmitoleyl hydrolase activity.

UniProtKB/Swiss-Prot Summary for NOTUM Gene

  • Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).

Additional gene information for NOTUM Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOTUM Gene

Genomics for NOTUM Gene

GeneHancer (GH) Regulatory Elements for NOTUM Gene

Promoters and enhancers for NOTUM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081958 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 500.7 +1.4 1439 3.2 CTCF POLR2G ZIC2 TCF7 ZNF423 GABPA ZBTB26 TARDBP REST ZBTB25 NOTUM MYADML2 ASPSCR1 CENPX MG828546
GH17J081962 Enhancer 1 ENCODE dbSUPER 500.7 -1.2 -1188 1.8 POLR2G USF1 TGIF2 ZKSCAN8 ZNF341 EZH2 SRSF1 NFIC KAT7 MBD1 NOTUM ASPSCR1 HGS FAAP100 TBCD ENSG00000265678 OGFOD3 NARF-IT1 ARL2BPP9 ENSG00000262652
GH17J081990 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 3.2 -30.0 -30006 2.9 EP300 ZSCAN5C POLR2G NCOR1 ZIC2 KDM6A TCF7 UBTF ZBTB25 TGIF2 FAAP100 TBCD NARF-IT1 HEXD ENSG00000260563 RFNG ENSG00000265678 TEPSIN ENSG00000262652 ARL2BPP9
GH17J081966 Promoter 0.7 Ensembl 0.7 -3.9 -3861 0.6 POLR2G ZMYM3 MITF PRPF4 CEBPB AGO2 ZNF362 ZNF384 ZNF121 ENSG00000264735 ASPSCR1 NOTUM
GH17J081957 Enhancer 0.5 Ensembl 0.7 +4.1 4139 0.2 POLR2G PCBP1 HNRNPH1 AGO2 HNRNPK RBFOX2 ENSG00000260563 OGFOD3 DUS1L TEPSIN MYADML2 ENSG00000262652 FAAP100 ARL2BPP9 HEXD SLC38A10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOTUM on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOTUM

Top Transcription factor binding sites by QIAGEN in the NOTUM gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • p53
  • YY1

Genomic Locations for NOTUM Gene

Genomic Locations for NOTUM Gene
chr17:81,952,507-81,961,840
(GRCh38/hg38)
Size:
9,334 bases
Orientation:
Minus strand
chr17:79,910,383-79,919,716
(GRCh37/hg19)
Size:
9,334 bases
Orientation:
Minus strand

Genomic View for NOTUM Gene

Genes around NOTUM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOTUM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOTUM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOTUM Gene

Proteins for NOTUM Gene

  • Protein details for NOTUM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P988-NOTUM_HUMAN
    Recommended name:
    Palmitoleoyl-protein carboxylesterase NOTUM
    Protein Accession:
    Q6P988
    Secondary Accessions:
    • Q8N410
    • Q8NI82

    Protein attributes for NOTUM Gene

    Size:
    496 amino acids
    Molecular mass:
    55699 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36872.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH60882.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB93501.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NOTUM Gene

neXtProt entry for NOTUM Gene

Post-translational modifications for NOTUM Gene

  • Glycosylation at Asn96
  • Modification sites at PhosphoSitePlus

Other Protein References for NOTUM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOTUM Gene

Domains & Families for NOTUM Gene

Gene Families for NOTUM Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NOTUM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOTUM Gene

GenScript: Design optimal peptide antigens:
  • Protein notum homolog (NOTUM_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P988

UniProtKB/Swiss-Prot:

NOTUM_HUMAN :
  • Belongs to the pectinacetylesterase family. Notum subfamily.
Family:
  • Belongs to the pectinacetylesterase family. Notum subfamily.
genes like me logo Genes that share domains with NOTUM: view

Function for NOTUM Gene

Molecular function for NOTUM Gene

UniProtKB/Swiss-Prot Function:
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+); Xref=Rhea:RHEA:45340, Rhea:RHEA-COMP:11170, Rhea:RHEA-COMP:11171, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:32372, ChEBI:CHEBI:85189; EC=3.1.1.98; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
Up-regulated in hepatocellular carcinoma (HCC) with high intracellular beta-catenin.

Enzyme Numbers (IUBMB) for NOTUM Gene

Phenotypes From GWAS Catalog for NOTUM Gene

Gene Ontology (GO) - Molecular Function for NOTUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004629 phospholipase C activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
GO:1990699 palmitoleyl hydrolase activity IDA 25731175
genes like me logo Genes that share ontologies with NOTUM: view
genes like me logo Genes that share phenotypes with NOTUM: view

Animal Model Products

CRISPR Products

miRNA for NOTUM Gene

miRTarBase miRNAs that target NOTUM

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOTUM Gene

Localization for NOTUM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOTUM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOTUM gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
cytoskeleton 2
nucleus 2
endosome 2
lysosome 2
mitochondrion 1
cytosol 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for NOTUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with NOTUM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NOTUM Gene

Pathways & Interactions for NOTUM Gene

genes like me logo Genes that share pathways with NOTUM: view

Pathways by source for NOTUM Gene

Gene Ontology (GO) - Biological Process for NOTUM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA,IEA 25731175
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0090090 negative regulation of canonical Wnt signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with NOTUM: view

No data available for SIGNOR curated interactions for NOTUM Gene

Drugs & Compounds for NOTUM Gene

No Compound Related Data Available

Transcripts for NOTUM Gene

mRNA/cDNA for NOTUM Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOTUM Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: -
SP3: -

Relevant External Links for NOTUM Gene

GeneLoc Exon Structure for
NOTUM

Expression for NOTUM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOTUM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOTUM Gene

This gene is overexpressed in Liver (x10.6), Muscle - Skeletal (x5.8), and Testis (x4.4).

Protein differential expression in normal tissues from HIPED for NOTUM Gene

This gene is overexpressed in Placenta (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOTUM Gene



Protein tissue co-expression partners for NOTUM Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOTUM

SOURCE GeneReport for Unigene cluster for NOTUM Gene:

Hs.106137

mRNA Expression by UniProt/SwissProt for NOTUM Gene:

Q6P988-NOTUM_HUMAN
Tissue specificity: Rarely expressed in adult normal tissues.

Evidence on tissue expression from TISSUES for NOTUM Gene

  • Pancreas(4.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with NOTUM: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NOTUM Gene

Orthologs for NOTUM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOTUM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOTUM 31 30
  • 97.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NOTUM 30
  • 91.29 (n)
dog
(Canis familiaris)
Mammalia NOTUM 31 30
  • 90.34 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Notum 30
  • 87.16 (n)
mouse
(Mus musculus)
Mammalia Notum 17 31 30
  • 86.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOTUM 31
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOTUM 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOTUM 31 30
  • 79.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOTUM 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia notum 30
  • 72.73 (n)
zebrafish
(Danio rerio)
Actinopterygii notum1a 31 30
  • 74.15 (n)
OneToMany
NOTUM (3 of 3) 31
  • 67 (a)
OneToMany
notum2 31
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Notum 31 30
  • 55.47 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45280 30
  • 39.86 (n)
rice
(Oryza sativa)
Liliopsida Os04g0602500 30
  • 41.26 (n)
Species where no ortholog for NOTUM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOTUM Gene

ENSEMBL:
Gene Tree for NOTUM (if available)
TreeFam:
Gene Tree for NOTUM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOTUM: view image

Paralogs for NOTUM Gene

No data available for Paralogs for NOTUM Gene

Variants for NOTUM Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOTUM Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
714076 Benign: not provided 81,956,915(-) G/A SYNONYMOUS_VARIANT
747602 Benign: not provided 81,956,946(-) C/T MISSENSE_VARIANT
811047 Uncertain Significance: not specified 81,953,173(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for NOTUM Gene

Structural Variations from Database of Genomic Variants (DGV) for NOTUM Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
nsv1133416 CNV deletion 24896259
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828137 CNV loss 20364138
nsv833569 CNV loss 17160897
nsv833571 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for NOTUM Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOTUM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOTUM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOTUM Gene

Disorders for NOTUM Gene

MalaCards: The human disease database

(8) MalaCards diseases for NOTUM Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NOTUM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOTUM

genes like me logo Genes that share disorders with NOTUM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOTUM Gene

Publications for NOTUM Gene

  1. Notum deacylates Wnt proteins to suppress signalling activity. (PMID: 25731175) Kakugawa S … Vincent JP (Nature 2015) 2 3 4 54
  2. Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF. (PMID: 18429952) Torisu Y … Aburatani H (Cancer science 2008) 3 4 54
  3. Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. (PMID: 31292548) Pentinmikko N … Katajisto P (Nature 2019) 3 54
  4. NOTUM Is Involved in the Progression of Colorectal Cancer. (PMID: 30343282) Yoon JH … Lee TG (Cancer genomics & proteomics 2018) 3 54
  5. A Single Kinase Generates the Majority of the Secreted Phosphoproteome. (PMID: 26091039) Tagliabracci VS … Dixon JE (Cell 2015) 4 54

Products for NOTUM Gene

  • Signalway ELISA kits for NOTUM
  • Signalway Proteins for NOTUM

Sources for NOTUM Gene