Aliases for NOTUM Gene
External Ids for NOTUM Gene
Previous GeneCards Identifiers for NOTUM Gene
GeneCards Summary for NOTUM Gene
NOTUM (Notum, Palmitoleoyl-Protein Carboxylesterase) is a Protein Coding gene. Diseases associated with NOTUM include Diabetes Mellitus, Permanent Neonatal. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Signaling by Hedgehog. Gene Ontology (GO) annotations related to this gene include hydrolase activity and palmitoleyl hydrolase activity.
UniProtKB/Swiss-Prot for NOTUM Gene
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).