Aliases for NOTCH2NLA Gene
External Ids for NOTCH2NLA Gene
Previous HGNC Symbols for NOTCH2NLA Gene
Previous GeneCards Identifiers for NOTCH2NLA Gene
GeneCards Summary for NOTCH2NLA Gene
NOTCH2NLA (Notch 2 N-Terminal Like A) is a Protein Coding gene. Diseases associated with NOTCH2NLA include Microcephaly. Among its related pathways are Notch Signaling Pathway (sino). An important paralog of this gene is NOTCH2NLC.
UniProtKB/Swiss-Prot Summary for NOTCH2NLA Gene
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).