Aliases for NOSTRIN Gene
External Ids for NOSTRIN Gene
Previous GeneCards Identifiers for NOSTRIN Gene
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]
GeneCards Summary for NOSTRIN Gene
NOSTRIN (Nitric Oxide Synthase Trafficking) is a Protein Coding gene. Diseases associated with NOSTRIN include Eclampsia and Pre-Eclampsia. Among its related pathways are eNOS activation and regulation and Nanog in Mammalian ESC Pluripotency. An important paralog of this gene is SH3KBP1.
UniProtKB/Swiss-Prot Summary for NOSTRIN Gene
Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.