Aliases for NOSIP Gene
External Ids for NOSIP Gene
Previous GeneCards Identifiers for NOSIP Gene
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2012]
GeneCards Summary for NOSIP Gene
NOSIP (Nitric Oxide Synthase Interacting Protein) is a Protein Coding gene. Diseases associated with NOSIP include Polyomavirus-Associated Nephropathy. Among its related pathways are eNOS activation and regulation and Nanog in Mammalian ESC Pluripotency.
UniProtKB/Swiss-Prot Summary for NOSIP Gene
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).