Aliases for NOS3 Gene
External Ids for NOS3 Gene
Previous GeneCards Identifiers for NOS3 Gene
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
GeneCards Summary for NOS3 Gene
NOS3 (Nitric Oxide Synthase 3) is a Protein Coding gene. Diseases associated with NOS3 include Stroke, Ischemic and Alzheimer Disease. Among its related pathways are Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics and eNOS activation and regulation. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and iron ion binding. An important paralog of this gene is NOS1.
UniProtKB/Swiss-Prot Summary for NOS3 Gene
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Endothelial nitric oxide synthase (eNOS), along with inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS), catalyze nitric oxide and L-citrulline generation from L-arginine and molecular oxygen. eNOS is activated at calcium concentrations over 100 nM.