Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Mageni... See more...

Aliases for NOS2 Gene

Aliases for NOS2 Gene

  • Nitric Oxide Synthase 2 2 3 5
  • HEP-NOS 2 3 4
  • INOS 2 3 4
  • Nitric Oxide Synthase 2A (Inducible, Hepatocytes) 2 3
  • Peptidyl-Cysteine S-Nitrosylase NOS2 3 4
  • Nitric Oxide Synthase 2, Inducible 2 3
  • Nitric Oxide Synthase, Inducible 3 4
  • Inducible NO Synthase 3 4
  • Hepatocyte NOS 3 4
  • Inducible NOS 3 4
  • EC 1.14.13.39 4 51
  • NOS2A 3 4
  • NOS 2 3
  • Nitric Oxide Synthase, Macrophage 3
  • NOS, Type II 3
  • NOS Type II 4
  • NOS2 5

External Ids for NOS2 Gene

Previous HGNC Symbols for NOS2 Gene

  • NOS2A

Previous GeneCards Identifiers for NOS2 Gene

  • GC17M023108
  • GC17M026083
  • GC17M022290

Summaries for NOS2 Gene

Entrez Gene Summary for NOS2 Gene

  • Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOS2 Gene

NOS2 (Nitric Oxide Synthase 2) is a Protein Coding gene. Diseases associated with NOS2 include Malaria and Meningioma, Radiation-Induced. Among its related pathways are Tuberculosis and VEGF Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity. An important paralog of this gene is NOS1.

UniProtKB/Swiss-Prot Summary for NOS2 Gene

  • Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).

Gene Wiki entry for NOS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOS2 Gene

Genomics for NOS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NOS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J027892 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 626.5 -92.9 -92859 2 CTCF PRDM10 ZNF512 LEF1 IKZF1 ZNF692 BACH1 JUND LARP7 MTA2 NOS2 ENSG00000266202 LYRM9 lnc-LYRM9-2
GH17J027800 Promoter/Enhancer 1 EPDnew ENCODE 600.7 -0.2 -183 1.1 ZIC2 SP1 CEBPA FOXA2 ATF3 YY1 JUND NR2F2 RAD21 SMAD4 NOS2 SLC13A2 LGALS9 ENSG00000266527 ENSG00000266202
GH17J027888 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 60 -88.5 -88472 2.8 CREB1 TEAD4 KDM1A TARDBP FOXA1 RELA IKZF2 POLR2A RELB RUNX3 NOS2 ENSG00000266202 LYRM9 ENSG00000266527
GH17J027878 Enhancer 0.9 Ensembl ENCODE 67.3 -79.0 -79003 1.9 CTCF ZNF143 REST RAD21 TRIM22 YY1 RELA NFE2 ZNF316 ZNF592 NOS2 LYRM9 ENSG00000266527 ENSG00000266202
GH17J027940 Enhancer 1 Ensembl ENCODE dbSUPER 28.6 -139.6 -139572 1.8 PRDM10 KDM1A TCF12 SP1 TRIM22 PKNOX1 SCRT2 RELB SCRT1 ELF1 NOS2 LYRM9 piR-43105-268 ENSG00000286589 LINC01992 NLK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOS2

Top Transcription factor binding sites by QIAGEN in the NOS2 gene promoter:
  • HNF-3beta
  • HNF-4alpha1
  • IRF-1
  • MyoD
  • p300

Genomic Locations for NOS2 Gene

Genomic Locations for NOS2 Gene
chr17:27,756,766-27,800,529
(GRCh38/hg38)
Size:
43,764 bases
Orientation:
Minus strand
chr17:26,083,792-26,127,555
(GRCh37/hg19)
Size:
43,764 bases
Orientation:
Minus strand

Genomic View for NOS2 Gene

Genes around NOS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOS2 Gene

Proteins for NOS2 Gene

  • Protein details for NOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35228-NOS2_HUMAN
    Recommended name:
    Nitric oxide synthase, inducible
    Protein Accession:
    P35228
    Secondary Accessions:
    • A1L3U5
    • B7ZLY2
    • O60757
    • O94994
    • Q16263
    • Q16692
    • Q4TTS5
    • Q9UD42

    Protein attributes for NOS2 Gene

    Size:
    1153 amino acids
    Molecular mass:
    131117 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=FMN; Xref=ChEBI:CHEBI:58210;
    Cofactor:
    Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560;
    Quaternary structure:
    • Homodimer (PubMed:10409685, PubMed:10074942). Interacts with SLC9A3R1 (PubMed:12080081). Interacts with GAPDH; induced by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112). Interacts with S100A8 and S100A9 to form the iNOS-S100A8/9 transnitrosylase complex (PubMed:25417112). Interacts with SPSB1, SPSB2 and SPSB4 (PubMed:21199876). Interacts with ELOC and CUL5 in the presence of SPSB1 or SPSB2 or SPSB4 (PubMed:21199876).

    Three dimensional structures from OCA and Proteopedia for NOS2 Gene

    Alternative splice isoforms for NOS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOS2 Gene

Selected DME Specific Peptides for NOS2 Gene

P35228:
  • VLEEFPS
  • YSRLPGKPK
  • SRQNLQSP
  • RGGCPADW
  • EEQVEDYFFQLK
  • GWYMGTE
  • LQVFDAR
  • SFKEAKIEE
  • EFTQLCIDLGWKP
  • GPLHHGVCSTW
  • AWRNAPRC
  • DGKHDFR
  • GDPANVE
  • PFNGWYM
  • VEINIAVL
  • FEIPPDLVLEV
  • RSAITVFPQR
  • ELLPQAIEF
  • KSLTRGPRDKPTP
  • VTKEIETTGTY
  • VVTSTFGNGD
  • WKTHVWQDE
  • CGDVRMARDVA
  • FRYAVFGLGSSMYP
  • EVGRRMGLE
  • FLLSQLPILKPR
  • FCAFAHDID
  • LDITTPP
  • EMFEHICRH
  • GNIRSAIT
  • DHHSAAESFMK
  • MTLVFGCR
  • QLIRYAGY
  • DTLHHKA
  • ATETGKS
  • RQRLEALCQPSEY
  • EIHLTVA
  • QALTYFLDIT
  • AVLHSFQKQNVTIMDHH
  • LKWYALP
  • TPVFHQEM
  • APFRSFWQQR
  • MEHPKYEWF

Post-translational modifications for NOS2 Gene

  • Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NOS2
  • Santa Cruz Biotechnology (SCBT) Antibodies for NOS2

Domains & Families for NOS2 Gene

Gene Families for NOS2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NOS2 Gene

InterPro:
Blocks:
  • Oxidoreductase FAD/NAD(P)-binding
  • Flavoprotein pyridine nucleotide cytochrome reductase signature
  • Flavodoxin signature
  • Flavodoxin/nitric oxide synthase
  • FAD-binding
  • Nitric oxide synthase, NOS
ProtoNet:

Suggested Antigen Peptide Sequences for NOS2 Gene

GenScript: Design optimal peptide antigens:
  • Peptidyl-cysteine S-nitrosylase NOS2 (NOS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35228

UniProtKB/Swiss-Prot:

NOS2_HUMAN :
  • Belongs to the NOS family.
Family:
  • Belongs to the NOS family.
genes like me logo Genes that share domains with NOS2: view

Function for NOS2 Gene

Molecular function for NOS2 Gene

UniProtKB/Swiss-Prot Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide; Xref=Rhea:RHEA:19897, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57743, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.39;.
UniProtKB/Swiss-Prot Induction:
By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta (PubMed:7528267). Down-regulated by zinc due to inhibition of NF-kappa-B transactivation activity (PubMed:25180171). By oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:25417112).
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity (By similarity).

Enzyme Numbers (IUBMB) for NOS2 Gene

Phenotypes From GWAS Catalog for NOS2 Gene

Gene Ontology (GO) - Molecular Function for NOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003958 NADPH-hemoprotein reductase activity IBA 21873635
GO:0004517 nitric-oxide synthase activity IBA,IDA 7504305
GO:0005515 protein binding IPI 12855682
GO:0005516 calmodulin binding IEA --
GO:0010181 FMN binding ISS --
genes like me logo Genes that share ontologies with NOS2: view
genes like me logo Genes that share phenotypes with NOS2: view

Animal Models for NOS2 Gene

MGI Knock Outs for NOS2:

Animal Model Products

CRISPR Products

miRNA for NOS2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOS2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOS2 Gene

Localization for NOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOS2 Gene

Cytoplasm, cytosol. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. {ECO:0000269 PubMed:21199876}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOS2 gene
Compartment Confidence
peroxisome 5
plasma membrane 4
nucleus 4
cytosol 4
extracellular 3
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,ISS --
GO:0005737 cytoplasm IEA,IDA 9916929
GO:0005777 peroxisome IDA 12085352
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with NOS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NOS2 Gene

Pathways & Interactions for NOS2 Gene

PathCards logo

SuperPathways for NOS2 Gene

SuperPathway Contained pathways
1 Arginine biosynthesis
2 Toxoplasmosis
3 G-Beta Gamma Signaling
.44
.37
4 PEDF Induced Signaling
.94
.46
5 Toll Comparative Pathway
.46
.34
genes like me logo Genes that share pathways with NOS2: view

Pathways by source for NOS2 Gene

11 GeneGo (Thomson Reuters) pathways for NOS2 Gene
  • Bacterial infections in CF airways
  • Development VEGF signaling via VEGFR2 - generic cascades
  • G-protein signaling_Rac2 regulation pathway
  • Immune response CCR3 signaling in eosinophils
  • Immune response Bacterial infections in normal airways
10 Qiagen pathways for NOS2 Gene
  • AMPK Enzyme Complex Pathway
  • Colorectal Cancer Metastasis
  • CRHR Pathway
  • Endothelin-1 Signaling Pathway
  • ILK Signaling

SIGNOR curated interactions for NOS2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001912 positive regulation of leukocyte mediated cytotoxicity TAS 10450191
GO:0002227 innate immune response in mucosa NAS 18390757
GO:0006527 arginine catabolic process IBA,IDA 7504305
GO:0006625 protein targeting to peroxisome TAS --
genes like me logo Genes that share ontologies with NOS2: view

Drugs & Compounds for NOS2 Gene

(133) Drugs for NOS2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist, Target, negative modulator Anti-inflammatory glucocorticoid 2886
Citrulline Approved, Investigational Nutra Target 0
Miconazole Approved, Investigational, Vet_approved Pharma Channel blocker, Pore Blocker, Antagonist, Target, inhibitor 3024
Minocycline Approved, Investigational Pharma Target, inhibitor 229
Nitric Oxide Approved Pharma 771

(63) Additional Compounds for NOS2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
N(omega)-Hydroxyarginine
  • N-OMEGA-hydroxy-L-arginine
  • N(Omega)-hydroxy-L-arginine
  • N(ω)-hydroxy-L-arginine
  • N(ω)-hydroxyarginine
  • 6-NOHA
53054-07-2

(5) Tocris Compounds for NOS2 Gene

Compound Action Cas Number
(S)-Methylisothiourea sulfate Highly selective iNOS inhibitor 867-44-7
Aminoguanidine hydrochloride Irreversible iNOS inhibitor 1937-19-5
AMT hydrochloride Potent, selective iNOS inhibitor 21463-31-0
EIT hydrobromide Selective iNOS inhibitor, acts arginine binding site 1071-37-0
S-Isopropylisothiourea hydrobromide iNOS inhibitor, acts at arginine binding site 4269-97-0

(22) ApexBio Compounds for NOS2 Gene

Compound Action Cas Number
(S)-Methylisothiourea sulfate 867-44-7
1400W dihydrochloride INOS inhibitor,potent and highly selective 214358-33-5
2,4-Diamino-6-hydroxypyrimidine 1956-06-4
2-Iminopiperidine hydrochloride 16011-96-4
3-Bromo-7-nitroindazole 74209-34-0
7-NINA 161467-34-1
7-Nitroindazole 2942-42-9
Aminoguanidine hydrochloride 1937-19-5
AMT hydrochloride 21463-31-0
AR-C 102222 253771-21-0
ARL 17477 dihydrochloride Selective nNOS inhibitor 866914-87-6
BYK 191023 dihydrochloride INOS inhibitor,potent and selective 1216722-25-6
Carboxy-PTIO, potassium salt 148819-94-7
DMPO 3317-61-1
EIT hydrobromide 1071-37-0
L-Canavanine sulfate 2219-31-0
L-NIL hydrochloride 150403-89-7
L-NMMA acetate 53308-83-1
ODQ 41443-28-1
Saikosaponin A COX-2 and iNOS inhibitor 20736-09-8
S-Isopropylisothiourea hydrobromide 4269-97-0
TRIM 25371-96-4
genes like me logo Genes that share compounds with NOS2: view

Drug Products

Transcripts for NOS2 Gene

mRNA/cDNA for NOS2 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOS2

Alternative Splicing Database (ASD) splice patterns (SP) for NOS2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2: -
SP3: -

ExUns: 26 ^ 27 ^ 28
SP1:
SP2:
SP3:

Relevant External Links for NOS2 Gene

GeneLoc Exon Structure for
NOS2

Expression for NOS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOS2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x8.6), Colon - Transverse (x7.9), and Brain - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for NOS2 Gene

This gene is overexpressed in Monocytes (35.0), Heart (13.8), and Neutrophil (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NOS2 Gene



Protein tissue co-expression partners for NOS2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOS2

SOURCE GeneReport for Unigene cluster for NOS2 Gene:

Hs.709191

mRNA Expression by UniProt/SwissProt for NOS2 Gene:

P35228-NOS2_HUMAN
Tissue specificity: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Evidence on tissue expression from TISSUES for NOS2 Gene

  • Liver(4.6)
  • Kidney(4.5)
  • Lung(4.5)
  • Eye(4.4)
  • Blood(3.3)
  • Nervous system(3.3)
  • Heart(3.3)
  • Muscle(3.2)
  • Intestine(3)
  • Spleen(2.6)
  • Lymph node(2.5)
  • Skin(2.4)
  • Pancreas(2.3)
  • Stomach(2.3)
  • Bone marrow(2.3)
  • Bone(2)
genes like me logo Genes that share expression patterns with NOS2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NOS2 Gene

Orthologs for NOS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NOS2 30 31
  • 99.48 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NOS2 30
  • 87.85 (n)
INOS 31
  • 86 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia NOS2 30 31
  • 87.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC497963 30
  • 82.52 (n)
Mouse
(Mus musculus)
Mammalia Nos2 30 17 31
  • 82.4 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NOS2 31
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NOS2 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NOS2 30 31
  • 68.43 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NOS2 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nos2 30
  • 65.96 (n)
Zebrafish
(Danio rerio)
Actinopterygii nos2b 30 31
  • 61.56 (n)
OneToMany
nos2a 31
  • 58 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Nos 31
  • 38 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NCP1 31
  • 24 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5751 31
  • 47 (a)
OneToMany
Species where no ortholog for NOS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NOS2 Gene

ENSEMBL:
Gene Tree for NOS2 (if available)
TreeFam:
Gene Tree for NOS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOS2: view image

Paralogs for NOS2 Gene

Variants for NOS2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NOS2 Gene

NOS2_HUMAN-P35228
Genetic variations in NOS2 are involved in resistance to malaria [MIM:611162].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOS2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
14013 Protective: Malaria, resistance to 27,801,702(-) G/A
709950 Likely Benign: not provided 27,765,618(-) G/A MISSENSE_VARIANT
710107 Benign: not provided 27,758,905(-) G/A SYNONYMOUS_VARIANT
710108 Benign: not provided 27,772,298(-) G/A INTRON_VARIANT
712632 Likely Benign: not provided 27,778,981(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NOS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NOS2 Gene

Variant ID Type Subtype PubMed ID
esv2715781 CNV deletion 23290073
esv2758683 CNV gain 17122850
esv28579 CNV gain 19812545
esv3640299 OTHER inversion 21293372
nsv471953 CNV novel sequence insertion 20440878
nsv9533 CNV gain 18304495
nsv960452 CNV duplication 23825009
nsv962299 CNV duplication 23825009

Variation tolerance for NOS2 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.85; 89.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOS2 Gene

Human Gene Mutation Database (HGMD)
NOS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOS2

SNP Genotyping and Copy Number Assay Products

Disorders for NOS2 Gene

MalaCards: The human disease database

(96) MalaCards diseases for NOS2 Gene - From: LncRNADisease, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malaria
  • malaria, susceptibility to
meningioma, radiation-induced
  • mnri
glioma susceptibility 1
  • glm1
borderline leprosy
  • borderline or dimorphous leprosy
chlamydia
  • chlamydia trachomatis infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search NOS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NOS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOS2 Gene

Publications for NOS2 Gene

  1. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. (PMID: 7682706) Geller DA … Billiar TR (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 23
  2. Genetic polymorphisms modifying oxidative stress are associated with disease activity in rheumatoid arthritis patients. (PMID: 19242068) Bohanec Grabar P … Dolzan V (Disease markers 2009) 3 23 41
  3. Influence of nitric oxide synthase gene polymorphisms on the risk of cardiovascular events in rheumatoid arthritis. (PMID: 19327239) Gonzalez-Gay MA … Martin J (Clinical and experimental rheumatology 2009) 3 23 41
  4. A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. (PMID: 12433515) Hobbs MR … Weinberg JB (Lancet (London, England) 2002) 3 4 41
  5. Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. (PMID: 10409685) Li H … Poulos TL (The Journal of biological chemistry 1999) 3 4 23

Products for NOS2 Gene

  • Addgene plasmids for NOS2

Sources for NOS2 Gene