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Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
NOS2 (Nitric Oxide Synthase 2) is a Protein Coding gene. Diseases associated with NOS2 include Malaria and Meningioma, Radiation-Induced. Among its related pathways are Tuberculosis and VEGF Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity. An important paralog of this gene is NOS1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003958 | NADPH-hemoprotein reductase activity | IBA | 21873635 |
GO:0004517 | nitric-oxide synthase activity | IBA,IDA | 7504305 |
GO:0005515 | protein binding | IPI | 12855682 |
GO:0005516 | calmodulin binding | IEA | -- |
GO:0010181 | FMN binding | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IBA,ISS | -- |
GO:0005737 | cytoplasm | IEA,IDA | 9916929 |
GO:0005777 | peroxisome | IDA | 12085352 |
GO:0005782 | peroxisomal matrix | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Arginine biosynthesis | ||
2 | Toxoplasmosis |
.34
|
.34
|
3 | G-Beta Gamma Signaling |
CRHR Pathway
.44
|
Relaxin Pathway
.37
|
4 | PEDF Induced Signaling |
MIF Regulation of Innate Immune Cells
.94
|
Endothelin-1 Signaling Pathway
.46
|
5 | Toll Comparative Pathway |
Immune response MIF in innate immunity response
.46
|
iNOS Signaling
.34
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEA | -- |
GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | TAS | 10450191 |
GO:0002227 | innate immune response in mucosa | NAS | 18390757 |
GO:0006527 | arginine catabolic process | IBA,IDA | 7504305 |
GO:0006625 | protein targeting to peroxisome | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dexamethasone | Approved, Investigational, Vet_approved | Pharma | Agonist, Target, negative modulator | Anti-inflammatory glucocorticoid | 2886 | |
Citrulline | Approved, Investigational | Nutra | Target | 0 | ||
Miconazole | Approved, Investigational, Vet_approved | Pharma | Channel blocker, Pore Blocker, Antagonist, Target, inhibitor | 3024 | ||
Minocycline | Approved, Investigational | Pharma | Target, inhibitor | 229 | ||
Nitric Oxide | Approved | Pharma | 771 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Hydrogen Ion |
|
|
||||
N(omega)-Hydroxyarginine |
|
53054-07-2 |
|
Compound | Action | Cas Number |
---|---|---|
(S)-Methylisothiourea sulfate | Highly selective iNOS inhibitor | 867-44-7 |
Aminoguanidine hydrochloride | Irreversible iNOS inhibitor | 1937-19-5 |
AMT hydrochloride | Potent, selective iNOS inhibitor | 21463-31-0 |
EIT hydrobromide | Selective iNOS inhibitor, acts arginine binding site | 1071-37-0 |
S-Isopropylisothiourea hydrobromide | iNOS inhibitor, acts at arginine binding site | 4269-97-0 |
Compound | Action | Cas Number |
---|---|---|
(S)-Methylisothiourea sulfate | 867-44-7 | |
1400W dihydrochloride | INOS inhibitor,potent and highly selective | 214358-33-5 |
2,4-Diamino-6-hydroxypyrimidine | 1956-06-4 | |
2-Iminopiperidine hydrochloride | 16011-96-4 | |
3-Bromo-7-nitroindazole | 74209-34-0 | |
7-NINA | 161467-34-1 | |
7-Nitroindazole | 2942-42-9 | |
Aminoguanidine hydrochloride | 1937-19-5 | |
AMT hydrochloride | 21463-31-0 | |
AR-C 102222 | 253771-21-0 | |
ARL 17477 dihydrochloride | Selective nNOS inhibitor | 866914-87-6 |
BYK 191023 dihydrochloride | INOS inhibitor,potent and selective | 1216722-25-6 |
Carboxy-PTIO, potassium salt | 148819-94-7 | |
DMPO | 3317-61-1 | |
EIT hydrobromide | 1071-37-0 | |
L-Canavanine sulfate | 2219-31-0 | |
L-NIL hydrochloride | 150403-89-7 | |
L-NMMA acetate | 53308-83-1 | |
ODQ | 41443-28-1 | |
Saikosaponin A | COX-2 and iNOS inhibitor | 20736-09-8 |
S-Isopropylisothiourea hydrobromide | 4269-97-0 | |
TRIM | 25371-96-4 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - |
ExUns: | 26 | ^ | 27 | ^ | 28 |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NOS2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NOS2 30 |
|
||
INOS 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | NOS2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC497963 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nos2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NOS2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NOS2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NOS2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NOS2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nos2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nos2b 30 31 |
|
OneToMany | |
nos2a 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Nos 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NCP1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5751 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
14013 | Protective: Malaria, resistance to | 27,801,702(-) | G/A | ||
709950 | Likely Benign: not provided | 27,765,618(-) | G/A | MISSENSE_VARIANT | |
710107 | Benign: not provided | 27,758,905(-) | G/A | SYNONYMOUS_VARIANT | |
710108 | Benign: not provided | 27,772,298(-) | G/A | INTRON_VARIANT | |
712632 | Likely Benign: not provided | 27,778,981(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2715781 | CNV | deletion | 23290073 |
esv2758683 | CNV | gain | 17122850 |
esv28579 | CNV | gain | 19812545 |
esv3640299 | OTHER | inversion | 21293372 |
nsv471953 | CNV | novel sequence insertion | 20440878 |
nsv9533 | CNV | gain | 18304495 |
nsv960452 | CNV | duplication | 23825009 |
nsv962299 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
malaria |
|
|
meningioma, radiation-induced |
|
|
glioma susceptibility 1 |
|
|
borderline leprosy |
|
|
chlamydia |
|
|