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Aliases for NOP9 Gene

Aliases for NOP9 Gene

  • NOP9 Nucleolar Protein 2 3 5
  • C14orf21 3 4
  • Pumilio Domain-Containing Protein C14orf21 3
  • NOP9 Nucleolar Protein Homolog (Yeast) 2
  • Chromosome 14 Open Reading Frame 21 2
  • NOP9 Nucleolar Protein Homolog 3
  • Nucleolar Protein 9 3
  • KIAA2021 4

External Ids for NOP9 Gene

Previous HGNC Symbols for NOP9 Gene

  • C14orf21

Previous GeneCards Identifiers for NOP9 Gene

  • GC14P024770

Summaries for NOP9 Gene

GeneCards Summary for NOP9 Gene

NOP9 (NOP9 Nucleolar Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for NOP9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP9 Gene

Genomics for NOP9 Gene

GeneHancer (GH) Regulatory Elements for NOP9 Gene

Promoters and enhancers for NOP9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I024298 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 0.0 -38 2.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 E2F8 ZNF143 FOS DHRS1 NOP9 LTB4R PIR40275 LOC102725044
GH14I024270 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 21.1 -27.0 -27028 5.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 LOC102725044 RABGGTA TSSK4 IPO4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1
GH14I023319 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20 -978.1 -978108 3.6 MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 PABPN1 ACIN1 NGDN PRMT5 RNF31 RNA5SP383 HOMEZ IPO4 NOP9 THTPA
GH14I023953 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 -345.8 -345750 2 HDGF SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 DHRS4 ACIN1 SDR39U1 NGDN RNA5SP383 RNF31 KHNYN TSSK4 DHRS4-AS1 PABPN1
GH14I024187 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 19 -111.5 -111544 2.6 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 IPO4 NGDN RNA5SP383 KHNYN RNF31 NFATC4 LOC102724814 ENSG00000259321 SDR39U1 SLC22A17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOP9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NOP9 Gene

Genomic Locations for NOP9 Gene
9,273 bases
Plus strand

Genomic View for NOP9 Gene

Genes around NOP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP9 Gene

Proteins for NOP9 Gene

  • Protein details for NOP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 9
    Protein Accession:
    Secondary Accessions:
    • A8MY76
    • Q8IVF0
    • Q8TBS6

    Protein attributes for NOP9 Gene

    636 amino acids
    Molecular mass:
    69438 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC23117.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP9 Gene


neXtProt entry for NOP9 Gene

Post-translational modifications for NOP9 Gene

  • Ubiquitination at Lys120 and Lys611
  • Modification sites at PhosphoSitePlus

Other Protein References for NOP9 Gene

No data available for DME Specific Peptides for NOP9 Gene

Domains & Families for NOP9 Gene

Gene Families for NOP9 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NOP9 Gene

Suggested Antigen Peptide Sequences for NOP9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NOP9 family.
  • Belongs to the NOP9 family.
genes like me logo Genes that share domains with NOP9: view

Function for NOP9 Gene

Phenotypes From GWAS Catalog for NOP9 Gene

Gene Ontology (GO) - Molecular Function for NOP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NOP9: view
genes like me logo Genes that share phenotypes with NOP9: view

Animal Model Products

CRISPR Products

miRNA for NOP9 Gene

miRTarBase miRNAs that target NOP9

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP9 Gene

Localization for NOP9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOP9 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with NOP9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NOP9 Gene

Pathways & Interactions for NOP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NOP9: view

No data available for Pathways by source and SIGNOR curated interactions for NOP9 Gene

Drugs & Compounds for NOP9 Gene

No Compound Related Data Available

Transcripts for NOP9 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP9 Gene

No ASD Table

Relevant External Links for NOP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOP9 Gene

Protein differential expression in normal tissues from HIPED for NOP9 Gene

This gene is overexpressed in Bone (15.1), Lung (11.1), and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOP9 Gene

Protein tissue co-expression partners for NOP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOP9 Gene:


Evidence on tissue expression from TISSUES for NOP9 Gene

  • Lung(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NOP9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOP9 Gene

Orthologs for NOP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOP9 34 33
  • 99.37 (n)
(Bos Taurus)
Mammalia C10H14orf21 33 34
  • 88.05 (n)
(Canis familiaris)
Mammalia NOP9 33
  • 87.12 (n)
C14ORF21 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Nop9 33
  • 83.49 (n)
(Mus musculus)
Mammalia Nop9 16 34 33
  • 83.02 (n)
(Monodelphis domestica)
Mammalia NOP9 34
  • 74 (a)
(Gallus gallus)
Aves LOC101750118 33
  • 51.39 (n)
NOP9 34
  • 41 (a)
(Anolis carolinensis)
Reptilia NOP9 34
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nop9 33
  • 56.81 (n)
Str.6747 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69156 33
(Danio rerio)
Actinopterygii LOC100332577 33
  • 49.28 (n)
AL954696.1 34
  • 35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011440 33
  • 42.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11123 33 34
  • 42.71 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR046W 33
  • 38.59 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP9 33 34 36
  • 38.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13685g 33
  • 38.01 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PUM23 33
  • 39.14 (n)
(Oryza sativa)
Liliopsida Os10g0390100 33
  • 39.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nop9 33
  • 36.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for NOP9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOP9 Gene

Gene Tree for NOP9 (if available)
Gene Tree for NOP9 (if available)

Paralogs for NOP9 Gene

(1) SIMAP similar genes for NOP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NOP9: view

No data available for Paralogs for NOP9 Gene

Variants for NOP9 Gene

Sequence variations from dbSNP and Humsavar for NOP9 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs374412139 A breast cancer sample 24,305,061(+) G/A 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
VAR_036456 A breast cancer sample p.Ser497Tyr
rs1000076387 -- 24,308,808(+) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000203991 -- 24,299,737(+) T/G upstream_transcript_variant
rs1000519268 -- 24,309,126(+) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NOP9 Gene

Variant ID Type Subtype PubMed ID
esv2669637 CNV deletion 23128226
esv3633804 CNV loss 21293372
nsv564058 CNV loss 21841781
nsv564059 CNV loss 21841781
nsv564060 CNV loss 21841781

Variation tolerance for NOP9 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP9 Gene

Disorders for NOP9 Gene

Additional Disease Information for NOP9

No disorders were found for NOP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP9 Gene

Publications for NOP9 Gene

  1. Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains. (PMID: 21653694) Dong S … Wang Z (The Journal of biological chemistry 2011) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58

Products for NOP9 Gene

Sources for NOP9 Gene

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