This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] See more...

Aliases for NOP16 Gene

Aliases for NOP16 Gene

  • NOP16 Nucleolar Protein 2 3 5
  • HBV Pre-S2 Trans-Regulated Protein 3 2 3 4
  • Hypothetical Protein HSPC111 2 3
  • Nucleolar Protein 16 3 4
  • NOP16 Nucleolar Protein Homolog (Yeast) 2
  • Nucleolar Protein 16 Homolog (Yeast) 2
  • NOP16 Nucleolar Protein Homolog 3
  • Nucleolar Protein 16 Homolog 3
  • HSPC111 3
  • HSPC185 3

External Ids for NOP16 Gene

Previous GeneCards Identifiers for NOP16 Gene

  • GC05M175744
  • GC05M175810
  • GC05M170735

Summaries for NOP16 Gene

Entrez Gene Summary for NOP16 Gene

  • This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOP16 Gene

NOP16 (NOP16 Nucleolar Protein) is a Protein Coding gene.

Additional gene information for NOP16 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOP16 Gene

Genomics for NOP16 Gene

GeneHancer (GH) Regulatory Elements for NOP16 Gene

Promoters and enhancers for NOP16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176386 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 756.5 +0.6 553 4.1 E2F8 ZNF785 SIN3A SP1 ZBTB40 SIX5 ZBTB6 RBPJ POLR2A CTBP1 HIGD2A NOP16 lnc-CLTB-1 FAF2 NSD1 UIMC1 ENSG00000251414 ENSG00000250909 ENSG00000240729 ZNF346-IT1
GH05J176410 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.2 -25.9 -25941 8.8 ZNF24 SP1 CTCF SREBF1 POLR2A MIXL1 MYC NFYC ZNF701 L3MBTL2 CLTB ARL10 UIMC1 ENSG00000251414 FAF2 NSD1 HIGD2A UNC5A GPRIN1 NOP16
GH05J176481 Enhancer 0.8 Ensembl ENCODE 11.4 -93.0 -92955 0.8 L3MBTL2 MAFK BACH1 DPF2 NFE2L2 HDAC1 ZNF316 ZNF24 NFE2 ZNF184 CLTB FAF2 HIGD2A NOP16 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 RF00017-5136
GH05J176491 Enhancer 0.6 Ensembl ENCODE 11.3 -102.2 -102226 0.8 REST SP1 FOSL2 CLTB HIGD2A NOP16 CDHR2 RN7SL684P FAF2 MIR1271 ARL10 KIAA1191 piR-47189
GH05J176492 Enhancer 0.5 Ensembl ENCODE 11.3 -103.4 -103435 1.3 ZNF623 NFIC CLTB HIGD2A NOP16 CDHR2 RN7SL684P FAF2 MIR1271 ARL10 KIAA1191 piR-47189
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOP16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOP16 gene promoter:
  • AP-2rep
  • COMP1
  • CUTL1
  • E2F
  • E2F-1
  • E47
  • Egr-2
  • GATA-1
  • GATA-2
  • Tal-1

Genomic Locations for NOP16 Gene

Genomic Locations for NOP16 Gene
chr5:176,383,937-176,388,975
(GRCh38/hg38)
Size:
5,039 bases
Orientation:
Minus strand
chr5:175,810,949-175,815,976
(GRCh37/hg19)
Size:
5,028 bases
Orientation:
Minus strand

Genomic View for NOP16 Gene

Genes around NOP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP16 Gene

Proteins for NOP16 Gene

  • Protein details for NOP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C1-NOP16_HUMAN
    Recommended name:
    Nucleolar protein 16
    Protein Accession:
    Q9Y3C1
    Secondary Accessions:
    • B4DV13
    • D6RGD3
    • Q05D05
    • Q6IAI6
    • Q6PIM0
    • Q8IXL5

    Protein attributes for NOP16 Gene

    Size:
    178 amino acids
    Molecular mass:
    21188 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH19331.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=BAG62525.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=EAW85085.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOP16 Gene

Post-translational modifications for NOP16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOP16 Gene

Domains & Families for NOP16 Gene

Gene Families for NOP16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOP16 Gene

Suggested Antigen Peptide Sequences for NOP16 Gene

GenScript: Design optimal peptide antigens:
  • HBV pre-S2 trans-regulated protein 3 (NOP16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3C1

UniProtKB/Swiss-Prot:

NOP16_HUMAN :
  • Belongs to the NOP16 family.
Family:
  • Belongs to the NOP16 family.
genes like me logo Genes that share domains with NOP16: view

Function for NOP16 Gene

Phenotypes From GWAS Catalog for NOP16 Gene

Gene Ontology (GO) - Molecular Function for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NOP16: view
genes like me logo Genes that share phenotypes with NOP16: view

Animal Model Products

CRISPR Products

miRNA for NOP16 Gene

miRTarBase miRNAs that target NOP16

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP16 Gene

Localization for NOP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP16 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOP16 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NOP16: view

Pathways & Interactions for NOP16 Gene

PathCards logo

SuperPathways for NOP16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042273 ribosomal large subunit biogenesis IBA 21873635
genes like me logo Genes that share ontologies with NOP16: view

No data available for Pathways by source and SIGNOR curated interactions for NOP16 Gene

Drugs & Compounds for NOP16 Gene

No Compound Related Data Available

Transcripts for NOP16 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP11:
SP12: - - - - - - - - -

Relevant External Links for NOP16 Gene

GeneLoc Exon Structure for
NOP16
ECgene alternative splicing isoforms for
NOP16

Expression for NOP16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOP16 Gene

Protein differential expression in normal tissues from HIPED for NOP16 Gene

This gene is overexpressed in Lung (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOP16 Gene



Protein tissue co-expression partners for NOP16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOP16 Gene:

NOP16

SOURCE GeneReport for Unigene cluster for NOP16 Gene:

Hs.696283

Evidence on tissue expression from TISSUES for NOP16 Gene

  • Lung(4.4)
  • Intestine(4.3)
  • Blood(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with NOP16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOP16 Gene

Orthologs for NOP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOP16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOP16 33 32
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NOP16 33 32
  • 91.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NOP16 33 32
  • 90.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nop16 32
  • 88.39 (n)
mouse
(Mus musculus)
Mammalia Nop16 17 33 32
  • 88.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOP16 33
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOP16 33
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOP16 33 32
  • 72.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP16 33
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nop16 32
  • 61.22 (n)
zebrafish
(Danio rerio)
Actinopterygii nop16 33 32
  • 56.83 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK265.6 33
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4994 33
  • 30 (a)
OneToOne
Species where no ortholog for NOP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP16 Gene

ENSEMBL:
Gene Tree for NOP16 (if available)
TreeFam:
Gene Tree for NOP16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOP16: view image

Paralogs for NOP16 Gene

No data available for Paralogs for NOP16 Gene

Variants for NOP16 Gene

Sequence variations from dbSNP and Humsavar for NOP16 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000108407 -- 176,384,619(-) T/G intron_variant
rs1000459344 -- 176,389,670(-) T/C upstream_transcript_variant
rs1001320589 -- 176,389,600(-) C/T upstream_transcript_variant
rs1001629098 -- 176,387,265(-) A/G intron_variant
rs1002462273 -- 176,386,761(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOP16 Gene

Variant ID Type Subtype PubMed ID
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781

Variation tolerance for NOP16 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOP16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP16 Gene

Disorders for NOP16 Gene

Additional Disease Information for NOP16

No disorders were found for NOP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP16 Gene

Publications for NOP16 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 56
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 56
  3. The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome. (PMID: 18373870) Butt AJ … Musgrove EA (Breast cancer research : BCR 2008) 3 23 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 56

Products for NOP16 Gene

Sources for NOP16 Gene