This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] See more...

Aliases for NOP16 Gene

Aliases for NOP16 Gene

  • NOP16 Nucleolar Protein 2 3 5
  • HBV Pre-S2 Trans-Regulated Protein 3 2 3 4
  • Hypothetical Protein HSPC111 2 3
  • Nucleolar Protein 16 3 4
  • HSPC111 2 3
  • HSPC185 2 3
  • NOP16 Nucleolar Protein Homolog (Yeast) 2
  • Nucleolar Protein 16 Homolog (Yeast) 2
  • NOP16 Nucleolar Protein Homolog 3
  • Nucleolar Protein 16 Homolog 3
  • LOC51491 2
  • NOP16 5

External Ids for NOP16 Gene

Previous GeneCards Identifiers for NOP16 Gene

  • GC05M175744
  • GC05M175810
  • GC05M170735

Summaries for NOP16 Gene

Entrez Gene Summary for NOP16 Gene

  • This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOP16 Gene

NOP16 (NOP16 Nucleolar Protein) is a Protein Coding gene. Diseases associated with NOP16 include Breast Cancer.

Additional gene information for NOP16 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOP16 Gene

Genomics for NOP16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NOP16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176386 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 606.5 +0.5 505 4.1 BRCA1 ARHGAP35 SP1 CREB1 PRDM10 REST ZNF629 RFX1 SIX5 LEF1 HIGD2A NOP16 lnc-CLTB-1 FAF2 NSD1 ENSG00000251414 ENSG00000250909 UIMC1 RPL21P60 MXD3
GH05J176410 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.3 -26.0 -25989 8.8 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 TFE3 KDM1A CTCF ZNF692 CLTB ENSG00000251414 FAF2 HIGD2A ARL10 NOP16 UIMC1 ENSG00000250909 MIR1271 KIAA1191
GH05J176481 Enhancer 0.9 Ensembl ENCODE 11.4 -93.0 -93003 0.8 JUND ZNF24 DPF2 HDAC1 ZNF184 NFE2 ZNF316 MAFF NR2C2 MAFK CLTB FAF2 HIGD2A NOP16 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 RF00017-5138
GH05J176491 Enhancer 0.6 Ensembl ENCODE 11.3 -102.3 -102274 0.8 FOXA1 REST SP1 FOSL2 BHLHE40 NR3C1 CLTB HIGD2A NOP16 CDHR2 RN7SL684P FAF2 MIR1271 ARL10 KIAA1191 piR-47189
GH05J176492 Enhancer 0.6 Ensembl ENCODE 11.3 -103.5 -103483 1.3 ZNF623 NFIC NR3C1 CLTB HIGD2A NOP16 CDHR2 RN7SL684P FAF2 MIR1271 ARL10 KIAA1191 piR-47189
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOP16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOP16

Top Transcription factor binding sites by QIAGEN in the NOP16 gene promoter:
  • AP-2rep
  • COMP1
  • CUTL1
  • E2F
  • E2F-1
  • E47
  • Egr-2
  • GATA-1
  • GATA-2
  • Tal-1

Genomic Locations for NOP16 Gene

Genomic Locations for NOP16 Gene
chr5:176,383,937-176,388,927
(GRCh38/hg38)
Size:
4,991 bases
Orientation:
Minus strand
chr5:175,810,949-175,815,976
(GRCh37/hg19)
Size:
5,028 bases
Orientation:
Minus strand

Genomic View for NOP16 Gene

Genes around NOP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP16 Gene

Proteins for NOP16 Gene

  • Protein details for NOP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C1-NOP16_HUMAN
    Recommended name:
    Nucleolar protein 16
    Protein Accession:
    Q9Y3C1
    Secondary Accessions:
    • B4DV13
    • D6RGD3
    • Q05D05
    • Q6IAI6
    • Q6PIM0
    • Q8IXL5

    Protein attributes for NOP16 Gene

    Size:
    178 amino acids
    Molecular mass:
    21188 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH19331.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAG62525.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=EAW85085.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOP16 Gene

Post-translational modifications for NOP16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOP16 Gene

Domains & Families for NOP16 Gene

Gene Families for NOP16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOP16 Gene

InterPro:
Blocks:
  • Extradiol ring-cleavage dioxygenase LigAB, LigA subunit
ProtoNet:

Suggested Antigen Peptide Sequences for NOP16 Gene

GenScript: Design optimal peptide antigens:
  • HBV pre-S2 trans-regulated protein 3 (NOP16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3C1

UniProtKB/Swiss-Prot:

NOP16_HUMAN :
  • Belongs to the NOP16 family.
Family:
  • Belongs to the NOP16 family.
genes like me logo Genes that share domains with NOP16: view

Function for NOP16 Gene

Phenotypes From GWAS Catalog for NOP16 Gene

Gene Ontology (GO) - Molecular Function for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NOP16: view
genes like me logo Genes that share phenotypes with NOP16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOP16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP16 Gene

Localization for NOP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP16 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOP16 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NOP16: view

Pathways & Interactions for NOP16 Gene

PathCards logo

SuperPathways for NOP16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042273 ribosomal large subunit biogenesis IBA 21873635
genes like me logo Genes that share ontologies with NOP16: view

No data available for Pathways by source and SIGNOR curated interactions for NOP16 Gene

Drugs & Compounds for NOP16 Gene

No Compound Related Data Available

Transcripts for NOP16 Gene

mRNA/cDNA for NOP16 Gene

8 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOP16

Alternative Splicing Database (ASD) splice patterns (SP) for NOP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP11:
SP12: - - - - - - - - -

Relevant External Links for NOP16 Gene

GeneLoc Exon Structure for
NOP16

Expression for NOP16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOP16 Gene

Protein differential expression in normal tissues from HIPED for NOP16 Gene

This gene is overexpressed in Lung (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOP16 Gene



Protein tissue co-expression partners for NOP16 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOP16

SOURCE GeneReport for Unigene cluster for NOP16 Gene:

Hs.696283

Evidence on tissue expression from TISSUES for NOP16 Gene

  • Skin(4.4)
  • Lung(4.4)
  • Intestine(4.3)
  • Blood(4.3)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with NOP16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOP16 Gene

Orthologs for NOP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOP16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NOP16 30 31
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NOP16 30 31
  • 91.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NOP16 30 31
  • 90.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nop16 30
  • 88.39 (n)
Mouse
(Mus musculus)
Mammalia Nop16 30 17 31
  • 88.2 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NOP16 31
  • 76 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NOP16 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NOP16 30 31
  • 72.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NOP16 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nop16 30
  • 61.22 (n)
Zebrafish
(Danio rerio)
Actinopterygii nop16 30 31
  • 56.83 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea ZK265.6 31
  • 20 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4994 31
  • 30 (a)
OneToOne
Species where no ortholog for NOP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NOP16 Gene

ENSEMBL:
Gene Tree for NOP16 (if available)
TreeFam:
Gene Tree for NOP16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOP16: view image

Paralogs for NOP16 Gene

No data available for Paralogs for NOP16 Gene

Variants for NOP16 Gene

Additional dbSNP identifiers (rs#s) for NOP16 Gene

Structural Variations from Database of Genomic Variants (DGV) for NOP16 Gene

Variant ID Type Subtype PubMed ID
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781

Variation tolerance for NOP16 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOP16

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOP16 Gene

Disorders for NOP16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOP16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NOP16 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NOP16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOP16 Gene

Publications for NOP16 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
  3. The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome. (PMID: 18373870) Butt AJ … Musgrove EA (Breast cancer research : BCR 2008) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4

Products for NOP16 Gene

Sources for NOP16 Gene