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Aliases for NOP14 Gene

Aliases for NOP14 Gene

  • NOP14 Nucleolar Protein 2 3 5
  • Nucleolar Protein 14 2 3
  • C4orf9 3 4
  • NOL14 3 4
  • NOP14 Nucleolar Protein Homolog (Yeast) 2
  • Probable Nucleolar Complex Protein 14 3
  • Nucleolar Protein 14 Homolog (Yeast) 2
  • Chromosome 4 Open Reading Frame 9 2
  • NOP14 Nucleolar Protein Homolog 3
  • NOP14 Homolog (S. Cerevisiae) 2
  • Nucleolar Complex Protein 14 4
  • RES4-25 3
  • RES425 3
  • UTP2 3

External Ids for NOP14 Gene

Previous HGNC Symbols for NOP14 Gene

  • C4orf9
  • NOL14

Previous GeneCards Identifiers for NOP14 Gene

  • GC04M002910

Summaries for NOP14 Gene

Entrez Gene Summary for NOP14 Gene

  • This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for NOP14 Gene

NOP14 (NOP14 Nucleolar Protein) is a Protein Coding gene. Diseases associated with NOP14 include Pancreatic Cancer. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include snoRNA binding.

UniProtKB/Swiss-Prot for NOP14 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).

Additional gene information for NOP14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP14 Gene

Genomics for NOP14 Gene

GeneHancer (GH) Regulatory Elements for NOP14 Gene

Promoters and enhancers for NOP14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I002961 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 476 3.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 GRK4 NOP14 SH3BP2 NOP14-AS1
GH04I002243 Enhancer 1.3 Ensembl ENCODE dbSUPER 20.4 +719.6 719605 1.4 HDGF ARNT YBX1 ZNF2 ZNF48 GLIS2 ARID2 ZNF143 KLF7 ZNF202 HAUS3 POLN RNF4 NELFA CRIPAK FAM193A NOP14 ENSG00000270195 MAEA MFSD10
GH04I002255 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 +704.2 704185 8.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 MXD4 FAM193A HAUS3 RNF4 NOP14 CRIPAK ADD1 ENSG00000244459 SLBP GC04M002217
GH04I002329 Enhancer 1.1 Ensembl ENCODE 21.8 +633.2 633227 1.3 HDGF ARNT ZNF133 FEZF1 ZNF2 GLIS2 ZNF416 FOS SP3 YY2 NELFA RNF4 CRIPAK HAUS3 FAM193A NOP14 ENSG00000270195 MFSD10 ENSG00000254094 ZFYVE28
GH04I002866 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10.8 +95.8 95801 3.4 ATF1 FOXA2 ARNT ARID4B YY1 TCF12 ZNF766 GATA2 E2F8 RXRA ADD1 GRK4 TNIP2 NOP14-AS1 MFSD10 NOP14 GC04P002843 GC04P002845 GC04P002844 GC04P002904
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOP14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOP14 gene promoter:

Genomic Locations for NOP14 Gene

Genomic Locations for NOP14 Gene
25,574 bases
Minus strand

Genomic View for NOP14 Gene

Genes around NOP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP14 Gene

Proteins for NOP14 Gene

  • Protein details for NOP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 14
    Protein Accession:
    Secondary Accessions:
    • D3DVR6
    • Q7LGI5
    • Q7Z6K0
    • Q8TBR6

    Protein attributes for NOP14 Gene

    857 amino acids
    Molecular mass:
    97668 Da
    Quaternary structure:
    • Component of the ribosomal small subunit (SSU) processome.
    • Sequence=AAB97011.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP14 Gene


neXtProt entry for NOP14 Gene

Post-translational modifications for NOP14 Gene

  • Ubiquitination at isoforms=834
  • Modification sites at PhosphoSitePlus

Other Protein References for NOP14 Gene

No data available for DME Specific Peptides for NOP14 Gene

Domains & Families for NOP14 Gene

Gene Families for NOP14 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NOP14 Gene


Suggested Antigen Peptide Sequences for NOP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NOP14 family.
  • Belongs to the NOP14 family.
genes like me logo Genes that share domains with NOP14: view

Function for NOP14 Gene

Molecular function for NOP14 Gene

UniProtKB/Swiss-Prot Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).

Phenotypes From GWAS Catalog for NOP14 Gene

Gene Ontology (GO) - Molecular Function for NOP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0019899 enzyme binding IPI 23382074
GO:0030515 snoRNA binding ISS --
genes like me logo Genes that share ontologies with NOP14: view
genes like me logo Genes that share phenotypes with NOP14: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP14 Gene

Localization for NOP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP14 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOP14 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 3
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA,ISS --
GO:0005739 mitochondrion ISS --
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with NOP14: view

Pathways & Interactions for NOP14 Gene

genes like me logo Genes that share pathways with NOP14: view

Gene Ontology (GO) - Biological Process for NOP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0000472 endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with NOP14: view

No data available for SIGNOR curated interactions for NOP14 Gene

Drugs & Compounds for NOP14 Gene

No Compound Related Data Available

Transcripts for NOP14 Gene

Unigene Clusters for NOP14 Gene

NOP14 nucleolar protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^
SP4: - - - -
SP5: -
SP6: -
SP7: -

ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: - - - -
SP4: - - - - -
SP8: - -

Relevant External Links for NOP14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOP14 Gene

This gene is overexpressed in Cervix (14.5), CD8 Tcells (12.0), and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOP14 Gene

Protein tissue co-expression partners for NOP14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOP14 Gene:


SOURCE GeneReport for Unigene cluster for NOP14 Gene:


Evidence on tissue expression from TISSUES for NOP14 Gene

  • Nervous system(4.9)
  • Intestine(4.4)
  • Liver(4.4)
  • Pancreas(3)
genes like me logo Genes that share expression patterns with NOP14: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOP14 Gene

Orthologs for NOP14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOP14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOP14 34 33
  • 99.46 (n)
(Rattus norvegicus)
Mammalia Nop14 33
  • 82.24 (n)
(Mus musculus)
Mammalia Nop14 33 16 34
  • 81.93 (n)
(Canis familiaris)
Mammalia NOP14 33 34
  • 80.86 (n)
(Bos Taurus)
Mammalia NOP14 33 34
  • 77.87 (n)
(Monodelphis domestica)
Mammalia NOP14 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
-- 34
  • 64 (a)
(Gallus gallus)
Aves NOP14 33 34
  • 67.38 (n)
(Anolis carolinensis)
Reptilia NOP14 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nop14 33
  • 64.44 (n)
LOC394902 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25698 33
(Danio rerio)
Actinopterygii nop14 33
  • 59.19 (n)
NOP14 34
  • 43 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta l(3)07882 34 33
  • 46.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000397 33
  • 45.31 (n)
(Caenorhabditis elegans)
Secernentea Y48G1A.4 34
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP14 36 34
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69070 33
  • 43.9 (n)
(Oryza sativa)
Liliopsida Os03g0598200 33
  • 45.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for NOP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP14 Gene

Gene Tree for NOP14 (if available)
Gene Tree for NOP14 (if available)

Paralogs for NOP14 Gene

No data available for Paralogs for NOP14 Gene

Variants for NOP14 Gene

Sequence variations from dbSNP and Humsavar for NOP14 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000019339 -- 2,952,277(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs10000927 -- 2,938,702(-) C/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000115863 -- 2,962,812(-) G/A intron_variant
rs10002702 -- 2,938,335(-) A/G/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000325986 -- 2,955,796(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOP14 Gene

Variant ID Type Subtype PubMed ID
dgv5082n100 CNV gain 25217958
esv1551216 CNV deletion 17803354
esv1601449 CNV insertion 17803354
esv1774334 CNV deletion 17803354
esv2726835 CNV deletion 23290073
esv2726865 CNV deletion 23290073
esv2726866 CNV deletion 23290073
esv2726867 CNV deletion 23290073
esv3575673 CNV gain 25503493
esv3599412 CNV gain 21293372
esv3599414 CNV gain 21293372
esv3599415 CNV gain 21293372
nsv1142382 CNV tandem duplication 24896259
nsv1142600 CNV deletion 24896259
nsv290690 CNV deletion 16902084
nsv461163 CNV gain 19166990
nsv474400 CNV novel sequence insertion 20440878
nsv475561 CNV novel sequence insertion 20440878
nsv593437 CNV gain 21841781
nsv593438 CNV gain 21841781
nsv954431 CNV insertion 24416366

Variation tolerance for NOP14 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.74; 94.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOP14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP14 Gene

Disorders for NOP14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOP14 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NOP14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOP14

genes like me logo Genes that share disorders with NOP14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOP14 Gene

Publications for NOP14 Gene

  1. The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (PMID: 9734812) Hadano S … Ikeda JE (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. (PMID: 11694595) Liu PC … Thiele DJ (Molecular biology of the cell 2001) 2 3 58
  5. Exon trapping and sequence-based methods of gene finding in transcript mapping of human 4p16.3. (PMID: 9661704) Pribill I … MacDonald ME (Somatic cell and molecular genetics 1997) 3 4 58

Products for NOP14 Gene

Sources for NOP14 Gene

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