This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by... See more...

Aliases for NONO Gene

Aliases for NONO Gene

  • Non-POU Domain Containing Octamer Binding 2 3 5
  • Non-POU Domain-Containing Octamer-Binding Protein 3 4
  • Protein Phosphatase 1, Regulatory Subunit 114 2 3
  • DNA-Binding P52/P100 Complex, 52 KDa Subunit 3 4
  • 54 KDa Nuclear RNA- And DNA-Binding Protein 3 4
  • 55 KDa Nuclear Protein 3 4
  • P54(Nrb) 3 4
  • NMT55 3 4
  • NRB54 3 4
  • Non-POU Domain-Containing Octamer (ATGCAAAT) Binding Protein 3
  • Non-Pou Domain-Containing Octamer (ATGCAAAT) Binding Protein 2
  • Non-POU-Domain-Containing, Octamer-Binding 2
  • Nuclear RNA-Binding Protein, 54-KD 2
  • NonO Protein 4
  • PPP1R114 3
  • MRXS34 3
  • P54NRB 3
  • P54nrb 4
  • P54 3

External Ids for NONO Gene

Previous GeneCards Identifiers for NONO Gene

  • GC0XP066677
  • GC16M070209
  • GC16M069524
  • GC16M069565
  • GC0XP069370
  • GC0XP070286
  • GC0XP070420
  • GC0XP070503
  • GC0XP064319

Summaries for NONO Gene

Entrez Gene Summary for NONO Gene

  • This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

GeneCards Summary for NONO Gene

NONO (Non-POU Domain Containing Octamer Binding) is a Protein Coding gene. Diseases associated with NONO include Mental Retardation, X-Linked, Syndromic 34 and Renal Cell Carcinoma, Xp11-Associated. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Circadian rhythm pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is SFPQ.

UniProtKB/Swiss-Prot Summary for NONO Gene

  • DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Gene Wiki entry for NONO Gene

Additional gene information for NONO Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NONO Gene

Genomics for NONO Gene

GeneHancer (GH) Regulatory Elements for NONO Gene

Promoters and enhancers for NONO Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NONO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NONO gene promoter:
  • ARP-1
  • CREB
  • deltaCREB
  • POU2F1
  • POU2F1a
  • YY1

Genomic Locations for NONO Gene

Genomic Locations for NONO Gene
chrX:71,283,192-71,301,168
(GRCh38/hg38)
Size:
17,977 bases
Orientation:
Plus strand
chrX:70,503,042-70,521,018
(GRCh37/hg19)
Size:
17,977 bases
Orientation:
Plus strand

Genomic View for NONO Gene

Genes around NONO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NONO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NONO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NONO Gene

Proteins for NONO Gene

  • Protein details for NONO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15233-NONO_HUMAN
    Recommended name:
    Non-POU domain-containing octamer-binding protein
    Protein Accession:
    Q15233
    Secondary Accessions:
    • B7Z4C2
    • D3DVV4
    • F5GYZ3
    • O00201
    • P30807
    • Q12786
    • Q9BQC5

    Protein attributes for NONO Gene

    Size:
    471 amino acids
    Molecular mass:
    54232 Da
    Quaternary structure:
    • Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits (PubMed:8439294, PubMed:15590677). NONO is a component of spliceosome and U5.4/6 snRNP complexes (PubMed:12403470). Interacts with CPNE4 (via VWFA domain) (By similarity). Forms heterodimers with PSPC1; this involves formation of a coiled coil domain by helices from both proteins (PubMed:16148043, PubMed:22416126). Part of complex consisting of SFPQ, NONO and MATR3 (PubMed:11525732). Part of a complex consisting of SFPQ, NONO and NR5A1 (PubMed:11897684). Part of a complex consisting of SFPQ, NONO and TOP1 (PubMed:9756848). Interacts with SPI1 (By similarity). Interacts with RNF43 (PubMed:18655028). Interacts with PER1 and PER2 (By similarity). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA (PubMed:28712728). Interacts (via second RRM domain) with WASL; the interaction is direct (PubMed:16767080). Component of a multiprotein complex with WASL and SFPQ (PubMed:16767080).

    Three dimensional structures from OCA and Proteopedia for NONO Gene

    Alternative splice isoforms for NONO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NONO Gene

Post-translational modifications for NONO Gene

  • The N-terminus is blocked.
  • Ubiquitination at Lys5, Lys99, Lys11, Lys107, Lys109, Lys126, Lys68, Lys198, Lys239, Lys243, Lys272, Lys279, Lys295, Lys336, and Lys371
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NONO Gene

Domains & Families for NONO Gene

Gene Families for NONO Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NONO Gene

GenScript: Design optimal peptide antigens:
  • p54(nrb) (NONO_HUMAN)
genes like me logo Genes that share domains with NONO: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NONO Gene

Function for NONO Gene

Molecular function for NONO Gene

UniProtKB/Swiss-Prot Function:
DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Gene Ontology (GO) - Molecular Function for NONO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISS --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with NONO: view
genes like me logo Genes that share phenotypes with NONO: view

Human Phenotype Ontology for NONO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for NONO Gene

miRTarBase miRNAs that target NONO

Clone Products

  • Addgene plasmids for NONO

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for NONO Gene

Localization for NONO Gene

Subcellular locations from UniProtKB/Swiss-Prot for NONO Gene

Nucleus. Nucleus, nucleolus. Nucleus speckle. Note=Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NONO gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NONO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,TAS --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0016020 membrane HDA 19946888
GO:0016363 nuclear matrix IDA 19874820
genes like me logo Genes that share ontologies with NONO: view

Pathways & Interactions for NONO Gene

genes like me logo Genes that share pathways with NONO: view

Pathways by source for NONO Gene

1 GeneGo (Thomson Reuters) pathway for NONO Gene

SIGNOR curated interactions for NONO Gene

Activates:

Gene Ontology (GO) - Biological Process for NONO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response IDA 28712728
GO:0002376 immune system process IEA --
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with NONO: view

Drugs & Compounds for NONO Gene

(2) Drugs for NONO Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(1) Additional Compounds for NONO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NONO: view

Transcripts for NONO Gene

CRISPR Products

Clone Products

  • Addgene plasmids for NONO

Alternative Splicing Database (ASD) splice patterns (SP) for NONO Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for NONO Gene

GeneLoc Exon Structure for
NONO
ECgene alternative splicing isoforms for
NONO

Expression for NONO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NONO Gene

Protein differential expression in normal tissues from HIPED for NONO Gene

This gene is overexpressed in Lymph node (12.5) and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NONO Gene



Protein tissue co-expression partners for NONO Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NONO Gene:

NONO

SOURCE GeneReport for Unigene cluster for NONO Gene:

Hs.533282

mRNA Expression by UniProt/SwissProt for NONO Gene:

Q15233-NONO_HUMAN
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines.

Evidence on tissue expression from TISSUES for NONO Gene

  • Kidney(5)
  • Nervous system(5)
  • Blood(4.9)
  • Muscle(4.9)
  • Skin(4.9)
  • Liver(4.8)
  • Lung(4.7)
  • Intestine(4.6)
  • Eye(4.4)
  • Stomach(4.1)
  • Spleen(3.7)
  • Heart(3.1)
  • Pancreas(3)
  • Adrenal gland(2.9)
  • Gall bladder(2.9)
  • Bone marrow(2.6)
  • Thyroid gland(2.6)
  • Lymph node(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NONO Gene

Germ Layers:
  • mesoderm
Systems:
  • urinary
Regions:
Abdomen:
  • kidney
genes like me logo Genes that share expression patterns with NONO: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NONO Gene

Orthologs for NONO Gene

This gene was present in the common ancestor of animals.

Orthologs for NONO Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 33
  • 100 (a)
OneToMany
-- 33
  • 99 (a)
OneToMany
NONO 32
  • 94.61 (n)
-- 33
  • 92 (a)
OneToMany
-- 33
  • 92 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia NONO 33 32
  • 100 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NONO 33 32
  • 94.96 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NONO 33
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nono 32
  • 91.93 (n)
mouse
(Mus musculus)
Mammalia Nono 17 33 32
  • 91.72 (n)
chicken
(Gallus gallus)
Aves NONO 33 32
  • 79.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NONO 33
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nono 32
  • 72.27 (n)
Str.5997 32
African clawed frog
(Xenopus laevis)
Amphibia efna2-prov 32
zebrafish
(Danio rerio)
Actinopterygii nono 33 32
  • 64.7 (n)
OneToOne
efna2 32
fruit fly
(Drosophila melanogaster)
Insecta nonA-l 33 34
  • 25 (a)
ManyToMany
nonA 33 34
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F25B5.7a 34
  • 46 (a)
nono-1 33
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 39 (a)
OneToMany
Species where no ortholog for NONO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NONO Gene

ENSEMBL:
Gene Tree for NONO (if available)
TreeFam:
Gene Tree for NONO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NONO: view image

Paralogs for NONO Gene

Paralogs for NONO Gene

(3) SIMAP similar genes for NONO Gene using alignment to 6 proteins:

  • NONO_HUMAN
  • C9IZL7_HUMAN
  • C9J4X2_HUMAN
  • C9JJ13_HUMAN
  • C9JYS8_HUMAN
  • H7C367_HUMAN

Pseudogenes.org Pseudogenes for NONO Gene

genes like me logo Genes that share paralogs with NONO: view

Variants for NONO Gene

Sequence variations from dbSNP and Humsavar for NONO Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1114167441 pathogenic, Mental retardation, X-linked, syndromic 34 71,298,508(+) G/T coding_sequence_variant, missense_variant
rs1555949579 uncertain-significance, Inborn genetic diseases 71,294,429(+) G/C coding_sequence_variant, missense_variant
rs1555950011 other, Medulloblastoma 71,296,640(+) AAAAAA/AAAAAAA coding_sequence_variant, frameshift
rs869025343 pathogenic, Mental retardation, X-linked, syndromic 34, not provided 71,297,938(+) G/A coding_sequence_variant, synonymous_variant
rs869025344 pathogenic, Mental retardation, X-linked, syndromic 34 71,300,051(+) CCCC/CCCCC coding_sequence_variant, frameshift

Structural Variations from Database of Genomic Variants (DGV) for NONO Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv33082 CNV loss 17666407
nsv508781 CNV insertion 20534489

Variation tolerance for NONO Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NONO Gene

Human Gene Mutation Database (HGMD)
NONO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NONO

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NONO Gene

Disorders for NONO Gene

MalaCards: The human disease database

(5) MalaCards diseases for NONO Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NONO in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NONO_HUMAN
  • Note=A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;X)(p11.2;q13.1) with TFE3. {ECO:0000269 PubMed:9393982}.
  • Mental retardation, X-linked, syndromic, 34 (MRXS34) [MIM:300967]: A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:26571461}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NONO

genes like me logo Genes that share disorders with NONO: view

No data available for Genatlas for NONO Gene

Publications for NONO Gene

  1. Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. (PMID: 8371983) Dong B … Krainer AR (Nucleic acids research 1993) 2 3 4 23 56
  2. Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins. (PMID: 18655028) Miyamoto K … Sugiura T (Proteomics 2008) 3 4 23 56
  3. Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor. (PMID: 15590677) Bladen CL … Dynan WS (The Journal of biological chemistry 2005) 3 4 23 56
  4. P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. (PMID: 16148043) Fox AH … Lamond AI (Molecular biology of the cell 2005) 3 4 23 56
  5. The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction. (PMID: 9756848) Straub T … Boege F (The Journal of biological chemistry 1998) 3 4 23 56

Products for NONO Gene

Sources for NONO Gene