This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex ... See more...

Aliases for NOMO1 Gene

Aliases for NOMO1 Gene

  • NODAL Modulator 1 2 3 5
  • PM5 2 3 4
  • Nodal Modulator 1 3 4
  • PM5 Protein, Telomeric Copy 3
  • Nodal Modulator 3 3
  • PM5 Protein 3 3
  • PM5 Protein 4
  • NOMO1 5
  • Nomo 3

External Ids for NOMO1 Gene

Previous GeneCards Identifiers for NOMO1 Gene

  • GC16P014836
  • GC16P014927
  • GC16P014730
  • GC16P014871
  • GC16P014872
  • GC16P014881
  • GC16P014892
  • GC16P014891
  • GC16P015037
  • GC16P014873
  • GC16P014874
  • GC16P014875
  • GC16P014876
  • GC16P014877
  • GC16P014878
  • GC16P014879
  • GC16P014880

Summaries for NOMO1 Gene

Entrez Gene Summary for NOMO1 Gene

  • This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008]

GeneCards Summary for NOMO1 Gene

NOMO1 (NODAL Modulator 1) is a Protein Coding gene. Diseases associated with NOMO1 include Pseudoxanthoma Elasticum and Superficial Urinary Bladder Cancer. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO2.

UniProtKB/Swiss-Prot Summary for NOMO1 Gene

Gene Wiki entry for NOMO1 Gene

Additional gene information for NOMO1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOMO1 Gene

Genomics for NOMO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NOMO1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J014833 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.7 +0.7 680 2.4 ZNF143 ZSCAN4 PKNOX1 CTCF SP2 ZXDB ZBTB2 ZNF580 ZBTB26 MNT NOMO1 PARN LOC100505915 HSALNG0109766-001 NPIPA1
GH16J014337 Enhancer 1.3 Ensembl ENCODE dbSUPER 6 -495.9 -495851 0.9 HNRNPL YBX1 SOX13 NFRKB RCOR2 TARDBP ZNF300 ZNF776 RBFOX2 RXRB PKD1P3 NPIPA2 LOC100505915 NPIPA3 PARN NPIPA1 NPIPP1 ERCC4 ENSG00000261819 PKD1P6
GH16J014362 Enhancer 1.1 Ensembl ENCODE 4.9 -469.4 -469420 3.4 HNRNPL CREB1 GATAD2A ZBTB33 ATF7 TFE3 SOX13 NFKBIZ RCOR2 TARDBP piR-50437-237 PARN BFAR PDXDC1 NOMO1 NPIPP1 LINC02130 lnc-PARN-9 lnc-PARN-10 MRTFB
GH16J015550 Enhancer 1.1 Ensembl ENCODE 4.1 +717.5 717480 1.2 GATAD2A CTCF TEAD4 ZNF629 TFE3 NFKBIZ ZNF692 RCOR2 JUND RXRB PARN BMERB1 MPV17L NOMO1 RF00017-1985 piR-33532 MARF1
GH16J015605 Enhancer 0.6 Ensembl 5.9 +771.7 771680 0.8 SP1 HMBOX1 YY1 GABPA JUND ZNF584 RAD21 HNF4A RXRA MAX lnc-NDE1-4 ENSG00000263335 NOMO1 PDXDC1 lnc-MYH11-1 piR-53710 MARF1 BMERB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOMO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOMO1

Top Transcription factor binding sites by QIAGEN in the NOMO1 gene promoter:
  • AML1a
  • AREB6
  • GATA-1
  • LCR-F1
  • Lmo2
  • MZF-1
  • p53
  • Pax-6
  • Sp1

Genomic Locations for NOMO1 Gene

Genomic Locations for NOMO1 Gene
62,437 bases
Plus strand
62,480 bases
Plus strand

Genomic View for NOMO1 Gene

Genes around NOMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOMO1 Gene

Proteins for NOMO1 Gene

  • Protein details for NOMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nodal modulator 1
    Protein Accession:
    Secondary Accessions:
    • P78421
    • Q8IW21
    • Q96DG0

    Protein attributes for NOMO1 Gene

    1222 amino acids
    Molecular mass:
    134324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOMO1 Gene

Post-translational modifications for NOMO1 Gene

  • Glycosylation at Asn50, Asn218, Asn369, and Asn618
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NOMO1_HUMAN (1572)

Other Protein References for NOMO1 Gene

Antibody Products

  • Boster Bio Antibodies for NOMO1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NOMO1

No data available for DME Specific Peptides for NOMO1 Gene

Domains & Families for NOMO1 Gene

Gene Families for NOMO1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NOMO1 Gene

  • Cna B-type

Suggested Antigen Peptide Sequences for NOMO1 Gene

GenScript: Design optimal peptide antigens:
  • pM5 protein (NOMO1_HUMAN)
genes like me logo Genes that share domains with NOMO1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NOMO1 Gene

Function for NOMO1 Gene

Molecular function for NOMO1 Gene

UniProtKB/Swiss-Prot Function:
May antagonize Nodal signaling.

Phenotypes From GWAS Catalog for NOMO1 Gene

Gene Ontology (GO) - Molecular Function for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 22046132
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with NOMO1: view
genes like me logo Genes that share phenotypes with NOMO1: view

Animal Model Products

CRISPR Products

miRNA for NOMO1 Gene

miRTarBase miRNAs that target NOMO1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOMO1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOMO1 Gene

Localization for NOMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOMO1 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOMO1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005789 endoplasmic reticulum membrane IBA 21873635
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NOMO1: view

Pathways & Interactions for NOMO1 Gene

PathCards logo

SuperPathways for NOMO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NOMO1: view

No data available for Pathways by source and SIGNOR curated interactions for NOMO1 Gene

Drugs & Compounds for NOMO1 Gene

(1) Drugs for NOMO1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Theophylline Approved Pharma Antagonist, Target 75
genes like me logo Genes that share compounds with NOMO1: view

Transcripts for NOMO1 Gene

mRNA/cDNA for NOMO1 Gene

4 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOMO1

Alternative Splicing Database (ASD) splice patterns (SP) for NOMO1 Gene

No ASD Table

Relevant External Links for NOMO1 Gene

GeneLoc Exon Structure for

Expression for NOMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOMO1 Gene

Protein differential expression in normal tissues from HIPED for NOMO1 Gene

This gene is overexpressed in Pancreas (9.0) and Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOMO1 Gene

Protein tissue co-expression partners for NOMO1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOMO1

SOURCE GeneReport for Unigene cluster for NOMO1 Gene:


mRNA Expression by UniProt/SwissProt for NOMO1 Gene:

Tissue specificity: Expressed in colon tumor tissue and in adjacent normal colonic mucosa.

Evidence on tissue expression from TISSUES for NOMO1 Gene

  • Lung(4.4)
  • Nervous system(4.3)
  • Liver(4.2)
  • Intestine(3.3)
  • Muscle(2.2)
  • Heart(2.1)
  • Skin(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with NOMO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOMO1 Gene

Orthologs for NOMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOMO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 31
  • 95 (a)
NOMO1 30
  • 90 (n)
(Pan troglodytes)
Mammalia -- 31
  • 95 (a)
(Bos Taurus)
Mammalia -- 31
  • 95 (a)
NOMO1 30
  • 88.48 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 87 (a)
(Rattus norvegicus)
Mammalia Nomo1 30
  • 86.79 (n)
(Mus musculus)
Mammalia Nomo1 30 31
  • 86.32 (n)
(Gallus gallus)
Aves -- 31
  • 86 (a)
PM5 30
  • 77.17 (n)
(Anolis carolinensis)
Reptilia -- 31
  • 87 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nomo3 30
  • 72.02 (n)
(Danio rerio)
Actinopterygii nomo 30 31
  • 66.67 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG1371 30 31
  • 45.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005856 30
  • 45.36 (n)
(Caenorhabditis elegans)
Secernentea nra-4 30 31
  • 43.03 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G62360 30
  • 45.06 (n)
(Oryza sativa)
Liliopsida Os01g0300600 30
  • 45.08 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4870 31
  • 37 (a)
Species where no ortholog for NOMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NOMO1 Gene

Gene Tree for NOMO1 (if available)
Gene Tree for NOMO1 (if available)
Evolutionary constrained regions (ECRs) for NOMO1: view image

Paralogs for NOMO1 Gene

Paralogs for NOMO1 Gene

(3) SIMAP similar genes for NOMO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NOMO1: view

Variants for NOMO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOMO1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
710343 Likely Benign: not provided 14,857,264(+) C/T SYNONYMOUS_VARIANT
rs1062412 - p.Asn490Asp
rs1345150579 - p.Lys458Asn
rs141860762 - p.Met493Val
rs17356851 - p.Met580Val

Additional dbSNP identifiers (rs#s) for NOMO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NOMO1 Gene

Variant ID Type Subtype PubMed ID
dgv111n111 CNV duplication 26073780
dgv112n111 CNV duplication 26073780
dgv2738n100 CNV gain 25217958
dgv2740n100 CNV loss 25217958
dgv2741n100 CNV gain+loss 25217958
dgv2742n100 CNV gain 25217958
dgv2744n100 CNV loss 25217958
dgv2745n100 CNV gain 25217958
dgv2746n100 CNV gain+loss 25217958
dgv2747n100 CNV loss 25217958
dgv2749n100 CNV gain 25217958
dgv2750n100 CNV loss 25217958
dgv2751n100 CNV gain 25217958
dgv2752n100 CNV gain+loss 25217958
dgv2753n100 CNV loss 25217958
dgv2754n100 CNV loss 25217958
dgv2755n100 CNV gain 25217958
dgv2756n100 CNV loss 25217958
dgv2757n100 CNV gain+loss 25217958
dgv791e212 CNV loss 25503493
esv22206 CNV gain+loss 19812545
esv2714012 CNV deletion 23290073
esv2714013 CNV deletion 23290073
esv2758632 CNV gain+loss 17122850
esv2760416 CNV gain+loss 21179565
esv2762254 CNV gain+loss 21179565
esv32598 CNV gain 17666407
esv3570331 CNV gain 25503493
esv3584701 CNV loss 24956385
esv994412 CNV gain 20482838
nsv103370 CNV deletion 16902084
nsv1038955 CNV loss 25217958
nsv1075912 CNV duplication 25765185
nsv1110264 CNV duplication 24896259
nsv1141278 CNV duplication 24896259
nsv1152913 CNV duplication 26484159
nsv1160344 CNV deletion 26073780
nsv1160345 CNV duplication 26073780
nsv1160346 CNV duplication 26073780
nsv433435 CNV gain 18776910
nsv442710 CNV gain 18776908
nsv471383 CNV gain 19718026
nsv499081 OTHER inversion 21111241
nsv509597 CNV insertion 20534489
nsv511045 OTHER complex 20534489
nsv7277 OTHER inversion 18451855
nsv9355 CNV gain+loss 18304495
nsv952929 CNV duplication 24416366
nsv974762 CNV duplication 23825009
nsv984263 CNV duplication 23825009

Variation tolerance for NOMO1 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOMO1 Gene

Disorders for NOMO1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NOMO1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pseudoxanthoma elasticum
  • pxe
superficial urinary bladder cancer
  • superficial urinary bladder carcinoma
ulcerative stomatitis
  • aphthous stomatitis
splenic abscess
bladder squamous cell carcinoma
  • epidermoid carcinoma of the urinary bladder
- elite association - COSMIC cancer census association via MalaCards
Search NOMO1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with NOMO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOMO1 Gene

Publications for NOMO1 Gene

  1. Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family. (PMID: 1310294) Templeton NS … Stetler-Stevenson WG (Genomics 1992) 2 3 4
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4
  3. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PMID: 15257293) Haffner C … Haass C (The EMBO journal 2004) 2 3
  4. Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PMID: 11139250) Perdu J … Germain DP (Human mutation 2001) 4 23
  5. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. (PMID: 30948266) Lee SH … Mayr C (Molecular cell 2019) 3

Products for NOMO1 Gene

Sources for NOMO1 Gene