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Aliases for NOM1 Gene

Aliases for NOM1 Gene

  • Nucleolar Protein With MIF4G Domain 1 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 113 2 3
  • SGD1 Homolog 3 4
  • C7orf3 3 4
  • Nucleolar MIF4G Domain-Containing Protein 1 3
  • Chromosome 7 Open Reading Frame 3 2
  • PPP1R113 3
  • SGD1 3

External Ids for NOM1 Gene

Previous HGNC Symbols for NOM1 Gene

  • C7orf3

Previous GeneCards Identifiers for NOM1 Gene

  • GC00U921619
  • GC07P156242
  • GC07P156435
  • GC07P156742
  • GC07P150475

Summaries for NOM1 Gene

Entrez Gene Summary for NOM1 Gene

  • Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NOM1 Gene

NOM1 (Nucleolar Protein With MIF4G Domain 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot for NOM1 Gene

  • Plays a role in targeting PPP1CA to the nucleolus.

Gene Wiki entry for NOM1 Gene

Additional gene information for NOM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOM1 Gene

Genomics for NOM1 Gene

GeneHancer (GH) Regulatory Elements for NOM1 Gene

Promoters and enhancers for NOM1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J156948 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 694.4 +0.8 766 3.8 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 NOM1 RPL36AP30 PIR33298
GH07J157335 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 56.4 +388.7 388676 5 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PIR48695 DNAJB6 NOM1 RPL36AP30 LOC100506585 GC07P157345 GC07M157268
GH07J157298 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 51.6 +351.2 351230 4.9 HDGF FOXA2 ARNT SIN3A YBX1 ZNF2 IRF4 POLR2B ZNF143 ZNF207 NOM1 UBE3C DNAJB6 GC07M157305 GC07M157304 ENSG00000229660 GC07M157268
GH07J156891 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.3 -56.7 -56697 2.9 HDGF SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LMBR1 LOC102723795 NOM1 LINC01006 RNU4-31P
GH07J157005 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23 +59.1 59071 5.8 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 MNX1 GC07M157007 NOM1 MNX1-AS1 MNX1-AS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOM1 gene promoter:
  • Nkx6-1

Genomic Locations for NOM1 Gene

Genomic Locations for NOM1 Gene
23,460 bases
Plus strand
23,460 bases
Plus strand

Genomic View for NOM1 Gene

Genes around NOM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOM1 Gene

Proteins for NOM1 Gene

  • Protein details for NOM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar MIF4G domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q96I08

    Protein attributes for NOM1 Gene

    860 amino acids
    Molecular mass:
    96257 Da
    Quaternary structure:
    • May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC.

neXtProt entry for NOM1 Gene

Post-translational modifications for NOM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOM1 Gene

Domains & Families for NOM1 Gene

Gene Families for NOM1 Gene

Suggested Antigen Peptide Sequences for NOM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CWC22 family.
  • Belongs to the CWC22 family.
genes like me logo Genes that share domains with NOM1: view

Function for NOM1 Gene

Molecular function for NOM1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in targeting PPP1CA to the nucleolus.

Gene Ontology (GO) - Molecular Function for NOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 17965019
genes like me logo Genes that share ontologies with NOM1: view
genes like me logo Genes that share phenotypes with NOM1: view

Animal Model Products

CRISPR Products

miRNA for NOM1 Gene

miRTarBase miRNAs that target NOM1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOM1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOM1 Gene

Localization for NOM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOM1 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOM1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA,IEA 15715967
genes like me logo Genes that share ontologies with NOM1: view

Pathways & Interactions for NOM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0022008 neurogenesis IBA --
GO:0042274 ribosomal small subunit biogenesis IBA --
GO:0048820 hair follicle maturation IEA --
genes like me logo Genes that share ontologies with NOM1: view

No data available for Pathways by source and SIGNOR curated interactions for NOM1 Gene

Drugs & Compounds for NOM1 Gene

No Compound Related Data Available

Transcripts for NOM1 Gene

mRNA/cDNA for NOM1 Gene

Unigene Clusters for NOM1 Gene

Nucleolar protein with MIF4G domain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOM1

Alternative Splicing Database (ASD) splice patterns (SP) for NOM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for NOM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOM1 Gene

This gene is overexpressed in Brain (35.9) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOM1 Gene:


SOURCE GeneReport for Unigene cluster for NOM1 Gene:


mRNA Expression by UniProt/SwissProt for NOM1 Gene:

Tissue specificity: Expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for NOM1 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with NOM1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOM1 Gene

Orthologs for NOM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOM1 34 33
  • 98.41 (n)
(Ornithorhynchus anatinus)
Mammalia NOM1 34
  • 78 (a)
(Mus musculus)
Mammalia Nom1 16 34 33
  • 76.14 (n)
(Bos Taurus)
Mammalia NOM1 34 33
  • 75.64 (n)
(Canis familiaris)
Mammalia NOM1 34 33
  • 75.21 (n)
(Rattus norvegicus)
Mammalia LOC682058 33
  • 70.25 (n)
(Monodelphis domestica)
Mammalia NOM1 34
  • 66 (a)
(Gallus gallus)
Aves NOM1 34 33
  • 72.42 (n)
(Anolis carolinensis)
Reptilia NOM1 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10492 33
(Danio rerio)
Actinopterygii nom1 34 33
  • 64.23 (n)
Dr.6026 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011285 33
  • 51.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9004 34 33
  • 49.42 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y52B11A.10 33
  • 42.1 (n)
Y52B11A.10 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGD1 36 34
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17930 33
  • 47.11 (n)
(Oryza sativa)
Liliopsida Os05g0147200 33
  • 47.51 (n)
Os.18996 33
Species where no ortholog for NOM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOM1 Gene

Gene Tree for NOM1 (if available)
Gene Tree for NOM1 (if available)
Evolutionary constrained regions (ECRs) for NOM1: view image

Paralogs for NOM1 Gene

No data available for Paralogs for NOM1 Gene

Variants for NOM1 Gene

Sequence variations from dbSNP and Humsavar for NOM1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000043819 -- 156,952,998(+) G/A intron_variant
rs1000078474 -- 156,968,695(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000267647 -- 156,955,041(+) G/A intron_variant
rs1000530213 -- 156,954,574(+) G/A intron_variant
rs1000619224 -- 156,948,255(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NOM1 Gene

Variant ID Type Subtype PubMed ID
esv2735655 CNV deletion 23290073
esv3615681 CNV loss 21293372
nsv1015433 CNV gain 25217958
nsv1141840 CNV insertion 24896259
nsv465249 CNV loss 19166990
nsv609210 CNV loss 21841781
nsv824415 CNV gain 20364138

Variation tolerance for NOM1 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.23; 99.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOM1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOM1 Gene

Disorders for NOM1 Gene

Additional Disease Information for NOM1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NOM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOM1 Gene

Publications for NOM1 Gene

  1. A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36. (PMID: 10329000) Heus HC … Heutink P (Genomics 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. NOM1 targets protein phosphatase I to the nucleolus. (PMID: 17965019) Gunawardena SR … Conklin KF (The Journal of biological chemistry 2008) 3 4 58
  4. Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. (PMID: 15715967) Simmons HM … Conklin KF (Gene 2005) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NOM1 Gene

Sources for NOM1 Gene

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