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Aliases for NOLC1 Gene

Aliases for NOLC1 Gene

  • Nucleolar And Coiled-Body Phosphoprotein 1 2 3 5
  • Hepatitis C Virus NS5A-Transactivated Protein 13 3 4
  • HCV NS5A-Transactivated Protein 13 3 4
  • 140 KDa Nucleolar Phosphoprotein 3 4
  • Nucleolar Phosphoprotein P130 3 4
  • Nucleolar 130 KDa Protein 3 4
  • NS5ATP13 3 4
  • NOPP140 3 4
  • Nucleolar And Coiled-Body Phosphprotein 1 3
  • HCV NS5A Trans-Regulated Protein 13 3
  • Nucleolar Protein P130 3
  • KIAA0035 4
  • NOPP130 3
  • P130 3

External Ids for NOLC1 Gene

Previous GeneCards Identifiers for NOLC1 Gene

  • GC10P102805
  • GC10P103145
  • GC10P104043
  • GC10P103576
  • GC10P103902
  • GC10P097544

Summaries for NOLC1 Gene

GeneCards Summary for NOLC1 Gene

NOLC1 (Nucleolar And Coiled-Body Phosphoprotein 1) is a Protein Coding gene. Diseases associated with NOLC1 include Hepatitis C Virus and Diffuse Gastric Cancer. Gene Ontology (GO) annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for NOLC1 Gene

  • Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).

Gene Wiki entry for NOLC1 Gene

Additional gene information for NOLC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOLC1 Gene

Genomics for NOLC1 Gene

GeneHancer (GH) Regulatory Elements for NOLC1 Gene

Promoters and enhancers for NOLC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I102150 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 205 3.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B NOLC1 HPS6 PPRC1 LDB1 GBF1 POLL ELOVL3
GH10I101828 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 28.5 -321.2 -321193 4.4 HDGF PKNOX1 CLOCK SMAD1 ARNT SIN3A ZNF2 ZBTB7B ZNF766 ZNF302 PPRC1 LDB1 GBF1 LZTS2 MRPL43 HPS6 NOLC1 SUFU ENSG00000272572 KCNIP2-AS1
GH10I102761 Enhancer 1.4 Ensembl ENCODE dbSUPER 29.2 +613.0 612972 6.6 PKNOX1 ATF1 ARNT SIN3A FEZF1 ZNF2 YY1 TCF12 ZNF766 GATA2 KCNIP2-AS1 SFXN2 NOLC1 WBP1L ARL3 RPEL1 AS3MT CYP17A1 PFN1P11 PTGES3P4
GH10I102131 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.3 -18.6 -18610 3.5 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PPRC1 HPS6 NOLC1 SFXN2 ARL3 KCNIP2-AS1 BORCS7 PIR37499 GC10M102134
GH10I102743 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14 +592.2 592233 2.6 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B WBP1L GC10P102744 GC10P102745 PDCD11 SFXN2 AS3MT PCGF6 TAF5 PPRC1 NOLC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOLC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOLC1 gene promoter:

Genomic Locations for NOLC1 Gene

Genomic Locations for NOLC1 Gene
chr10:102,152,176-102,163,871
(GRCh38/hg38)
Size:
11,696 bases
Orientation:
Plus strand
chr10:103,911,933-103,923,627
(GRCh37/hg19)

Genomic View for NOLC1 Gene

Genes around NOLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOLC1 Gene

Proteins for NOLC1 Gene

  • Protein details for NOLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14978-NOLC1_HUMAN
    Recommended name:
    Nucleolar and coiled-body phosphoprotein 1
    Protein Accession:
    Q14978
    Secondary Accessions:
    • Q15030
    • Q5VV70
    • Q9BUV3

    Protein attributes for NOLC1 Gene

    Size:
    699 amino acids
    Molecular mass:
    73603 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with TCOF1 following monoubiquitination (PubMed:26399832). Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II (PubMed:10567578). Interacts with DKC1/NAP57, NOP58 and fibrillarin (By similarity).

    Alternative splice isoforms for NOLC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOLC1 Gene

Post-translational modifications for NOLC1 Gene

  • Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
  • Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. NOLC1 is one of the mostly phosphorylated proteins in the cell.
  • Ubiquitination at isoforms=259

No data available for DME Specific Peptides for NOLC1 Gene

Domains & Families for NOLC1 Gene

Gene Families for NOLC1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NOLC1 Gene

Suggested Antigen Peptide Sequences for NOLC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOLC1: view

No data available for UniProtKB/Swiss-Prot for NOLC1 Gene

Function for NOLC1 Gene

Molecular function for NOLC1 Gene

UniProtKB/Swiss-Prot Function:
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).

Phenotypes From GWAS Catalog for NOLC1 Gene

Gene Ontology (GO) - Molecular Function for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001042 RNA polymerase I core binding IDA 26399832
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 17620599
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with NOLC1: view
genes like me logo Genes that share phenotypes with NOLC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOLC1 Gene

Localization for NOLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOLC1 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase. {ECO:0000269 PubMed:7657714}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOLC1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IDA,TAS --
GO:0005737 cytoplasm IEA,TAS --
genes like me logo Genes that share ontologies with NOLC1: view

Pathways & Interactions for NOLC1 Gene

SuperPathways for NOLC1 Gene

No Data Available

SIGNOR curated interactions for NOLC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS 7657714
GO:0006364 rRNA processing TAS 7657714
GO:0006417 regulation of translation IMP 26399832
GO:0007000 nucleolus organization IEA --
GO:0007049 cell cycle TAS 7657714
genes like me logo Genes that share ontologies with NOLC1: view

No data available for Pathways by source for NOLC1 Gene

Drugs & Compounds for NOLC1 Gene

(6) Drugs for NOLC1 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Target Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1828
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1828
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with NOLC1: view

Transcripts for NOLC1 Gene

Unigene Clusters for NOLC1 Gene

Nucleolar and coiled-body phosphoprotein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOLC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3: - - - -
SP4: -
SP5:
SP6: - - -
SP7: -
SP8: - - - - - - -
SP9:

Relevant External Links for NOLC1 Gene

GeneLoc Exon Structure for
NOLC1
ECgene alternative splicing isoforms for
NOLC1

Expression for NOLC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOLC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOLC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.3), Adrenal (10.4), Nasal epithelium (9.8), and Lung (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOLC1 Gene



Protein tissue co-expression partners for NOLC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOLC1 Gene:

NOLC1

SOURCE GeneReport for Unigene cluster for NOLC1 Gene:

Hs.523238

Evidence on tissue expression from TISSUES for NOLC1 Gene

  • Lung(4.6)
  • Liver(4.4)
  • Nervous system(4.3)
  • Bone marrow(4.2)
  • Intestine(2.7)
  • Skin(2.7)
genes like me logo Genes that share expression patterns with NOLC1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOLC1 Gene

Orthologs for NOLC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOLC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOLC1 33 34
  • 99 (n)
dog
(Canis familiaris)
Mammalia NOLC1 33 34
  • 82.69 (n)
cow
(Bos Taurus)
Mammalia NOLC1 33 34
  • 79 (n)
rat
(Rattus norvegicus)
Mammalia Nolc1 33
  • 77.17 (n)
mouse
(Mus musculus)
Mammalia Nolc1 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOLC1 34
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOLC1 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOLC1 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOLC1 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC395027 33
African clawed frog
(Xenopus laevis)
Amphibia xNopp180 33
zebrafish
(Danio rerio)
Actinopterygii nolc1 34
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dao-5 34
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP40 34
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11097 34
  • 29 (a)
OneToOne
Species where no ortholog for NOLC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOLC1 Gene

ENSEMBL:
Gene Tree for NOLC1 (if available)
TreeFam:
Gene Tree for NOLC1 (if available)

Paralogs for NOLC1 Gene

Pseudogenes.org Pseudogenes for NOLC1 Gene

genes like me logo Genes that share paralogs with NOLC1: view

No data available for Paralogs for NOLC1 Gene

Variants for NOLC1 Gene

Sequence variations from dbSNP and Humsavar for NOLC1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000194324 -- 102,150,419(+) T/G upstream_transcript_variant
rs1000390197 -- 102,162,930(+) C/A/T 3_prime_UTR_variant
rs1000522434 -- 102,155,308(+) T/C intron_variant
rs1000658253 -- 102,155,079(+) A/G intron_variant
rs1000670984 -- 102,161,764(+) A/G intron_variant

Variation tolerance for NOLC1 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOLC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NOLC1 Gene

Disorders for NOLC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOLC1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
diffuse gastric cancer
  • signet ring cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NOLC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOLC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NOLC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOLC1 Gene

Publications for NOLC1 Gene

  1. Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. (PMID: 10567578) Chen HK … Yeh NH (Molecular and cellular biology 1999) 2 3 4 22 58
  2. Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. (PMID: 7657714) Pai CY … Yeh NH (Journal of cell science 1995) 2 3 4 22 58
  3. The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. (PMID: 9016786) Chen HK … Yeh NH (Biochemical and biophysical research communications 1997) 3 4 22 58
  4. Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. (PMID: 8630004) Pai CY … Yeh NH (Biochemical and biophysical research communications 1996) 3 4 22 58
  5. Cell-fate determination by ubiquitin-dependent regulation of translation. (PMID: 26399832) Werner A … Rape M (Nature 2015) 3 4 58

Products for NOLC1 Gene

Sources for NOLC1 Gene

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