Aliases for NOLC1 Gene
- Nucleolar And Coiled-Body Phosphoprotein 1 2 3 3 5
- Hepatitis C Virus NS5A-Transactivated Protein 13 3 4
- HCV NS5A-Transactivated Protein 13 3 4
- 140 KDa Nucleolar Phosphoprotein 3 4
- Nucleolar Phosphoprotein P130 3 4
- Nucleolar 130 KDa Protein 3 4
- NS5ATP13 3 4
- Nucleolar And Coiled-Body Phosphprotein 1 3
External Ids for NOLC1 Gene
Previous GeneCards Identifiers for NOLC1 Gene
GeneCards Summary for NOLC1 Gene
NOLC1 (Nucleolar And Coiled-Body Phosphoprotein 1) is a Protein Coding gene. Diseases associated with NOLC1 include Hepatitis C Virus and Diffuse Gastric Cancer. Gene Ontology (GO) annotations related to this gene include GTP binding.
UniProtKB/Swiss-Prot for NOLC1 Gene
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).