NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008] See more...

Aliases for NOL8 Gene

Aliases for NOL8 Gene

  • Nucleolar Protein 8 2 3 4 5
  • Nucleolar Protein Nop132 3 4
  • C9orf34 3 4
  • NOP132 3 4
  • Chromosome 9 Open Reading Frame 34 2
  • BA62C3.3 3
  • BA62C3.4 3

External Ids for NOL8 Gene

Previous HGNC Symbols for NOL8 Gene

  • C9orf34

Previous GeneCards Identifiers for NOL8 Gene

  • GC09M090401
  • GC09M092139
  • GC09M094099
  • GC09M095059
  • GC09M064737

Summaries for NOL8 Gene

Entrez Gene Summary for NOL8 Gene

  • NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NOL8 Gene

NOL8 (Nucleolar Protein 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot Summary for NOL8 Gene

  • Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.

Gene Wiki entry for NOL8 Gene

Additional gene information for NOL8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOL8 Gene

Genomics for NOL8 Gene

GeneHancer (GH) Regulatory Elements for NOL8 Gene

Promoters and enhancers for NOL8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOL8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOL8

Top Transcription factor binding sites by QIAGEN in the NOL8 gene promoter:
  • AP-1
  • Cart-1
  • FOXO4
  • HTF
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pax-4a

Genomic Locations for NOL8 Gene

Genomic Locations for NOL8 Gene
chr9:92,297,358-92,325,994
(GRCh38/hg38)
Size:
28,637 bases
Orientation:
Minus strand
chr9:95,059,640-95,087,918
(GRCh37/hg19)
Size:
28,279 bases
Orientation:
Minus strand

Genomic View for NOL8 Gene

Genes around NOL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL8 Gene

Proteins for NOL8 Gene

  • Protein details for NOL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76FK4-NOL8_HUMAN
    Recommended name:
    Nucleolar protein 8
    Protein Accession:
    Q76FK4
    Secondary Accessions:
    • Q5TCC7
    • Q5TCC8
    • Q5TCD3
    • Q5TCD5
    • Q5TCD6
    • Q5TCD7
    • Q76D35
    • Q7L3E2
    • Q9H586
    • Q9H795
    • Q9H7W7
    • Q9H9J6
    • Q9NWA4
    • Q9NWM4

    Protein attributes for NOL8 Gene

    Size:
    1167 amino acids
    Molecular mass:
    131616 Da
    Quaternary structure:
    • Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent.
    SequenceCaution:
    • Sequence=BAA91356.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91356.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB14229.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15003.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL8 Gene

Post-translational modifications for NOL8 Gene

No data available for DME Specific Peptides for NOL8 Gene

Domains & Families for NOL8 Gene

Gene Families for NOL8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL8 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOL8 Gene

GenScript: Design optimal peptide antigens:
  • NOL8 protein (A6H8Z4_HUMAN)
  • Nucleolar protein Nop132 (NOL8_HUMAN)
genes like me logo Genes that share domains with NOL8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NOL8 Gene

Function for NOL8 Gene

Molecular function for NOL8 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated in diffuse-type gastric cancers.

Phenotypes From GWAS Catalog for NOL8 Gene

Gene Ontology (GO) - Molecular Function for NOL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA 21873635
GO:0005515 protein binding IPI 11073942
genes like me logo Genes that share ontologies with NOL8: view
genes like me logo Genes that share phenotypes with NOL8: view

Animal Models for NOL8 Gene

MGI Knock Outs for NOL8:
  • Nol8 Nol8<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for NOL8 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOL8 Gene

Localization for NOL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL8 Gene

Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL8 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005730 nucleolus IEA,IDA 14660641
GO:1990904 ribonucleoprotein complex IBA 21873635
genes like me logo Genes that share ontologies with NOL8: view

Pathways & Interactions for NOL8 Gene

PathCards logo

SuperPathways for NOL8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IMP 16963496
GO:1902570 protein localization to nucleolus IMP 16963496
genes like me logo Genes that share ontologies with NOL8: view

No data available for Pathways by source and SIGNOR curated interactions for NOL8 Gene

Drugs & Compounds for NOL8 Gene

(1) Drugs for NOL8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with NOL8: view

Transcripts for NOL8 Gene

mRNA/cDNA for NOL8 Gene

3 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
29 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - - - - -
SP2:
SP3: - - - - - -
SP4:
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - - -
SP13: - -
SP14:
SP15: -
SP16:

ExUns: 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NOL8 Gene

GeneLoc Exon Structure for
NOL8

Expression for NOL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL8 Gene

This gene is overexpressed in Monocytes (27.3), Serum (15.9), and Platelet (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOL8 Gene



Protein tissue co-expression partners for NOL8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOL8

SOURCE GeneReport for Unigene cluster for NOL8 Gene:

Hs.442199

mRNA Expression by UniProt/SwissProt for NOL8 Gene:

Q76FK4-NOL8_HUMAN
Tissue specificity: Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.

Evidence on tissue expression from TISSUES for NOL8 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with NOL8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL8 Gene

Orthologs for NOL8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL8 31 30
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NOL8 31 30
  • 83.15 (n)
OneToMany
-- 31
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NOL8 31 30
  • 77.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nol8 17 31 30
  • 77.28 (n)
rat
(Rattus norvegicus)
Mammalia Nol8 30
  • 76.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOL8 31
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOL8 31
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOL8 31 30
  • 56.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOL8 31
  • 40 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14813 30
zebrafish
(Danio rerio)
Actinopterygii nol8 31
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14230 31
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
OneToOne
Species where no ortholog for NOL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL8 Gene

ENSEMBL:
Gene Tree for NOL8 (if available)
TreeFam:
Gene Tree for NOL8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOL8: view image

Paralogs for NOL8 Gene

(4) SIMAP similar genes for NOL8 Gene using alignment to 13 proteins:

  • NOL8_HUMAN
  • A6H8Z4_HUMAN
  • F5GWN9_HUMAN
  • F5GXV1_HUMAN
  • F5H0I5_HUMAN
  • F5H101_HUMAN
  • F5H532_HUMAN
  • F5H540_HUMAN
  • F5H692_HUMAN
  • F5H797_HUMAN
  • F5H7D5_HUMAN
  • F5H8B8_HUMAN
  • F8WE42_HUMAN

Pseudogenes.org Pseudogenes for NOL8 Gene

genes like me logo Genes that share paralogs with NOL8: view

No data available for Paralogs for NOL8 Gene

Variants for NOL8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOL8 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs15717 - p.Asp841Glu
rs2236344 - p.Val748Leu
rs34224798 - p.Glu988Asp
rs58545014 - p.Gly470Glu
rs921122 - p.Gly1021Ser

Additional dbSNP identifiers (rs#s) for NOL8 Gene

Structural Variations from Database of Genomic Variants (DGV) for NOL8 Gene

Variant ID Type Subtype PubMed ID
esv3621078 CNV loss 21293372
esv3891693 CNV gain 25118596
nsv1045165 CNV loss 25217958
nsv1046733 CNV gain 25217958

Variation tolerance for NOL8 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL8 Gene

Human Gene Mutation Database (HGMD)
NOL8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL8 Gene

Disorders for NOL8 Gene

Additional Disease Information for NOL8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NOL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL8 Gene

Publications for NOL8 Gene

  1. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PMID: 14660641) Sekiguchi T … Nishimoto T (The Journal of biological chemistry 2004) 3 4 23 54
  2. Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. (PMID: 15132771) Jinawath N … Nakamura Y (Cancer science 2004) 2 3 4 54
  3. NOL8, the binding protein for beta-catenin, promoted the growth and migration of prostate cancer cells. (PMID: 30125550) Gu S … Xu Z (Chemico-biological interactions 2018) 2 3 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54

Products for NOL8 Gene

Sources for NOL8 Gene