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Aliases for NOL7 Gene

Aliases for NOL7 Gene

  • Nucleolar Protein 7 2 3 4 5
  • Polyglutamine Binding Protein 3 2 3
  • Nucleolar Protein Of 27 KDa 3 4
  • Nucleolar Protein 7, 27kDa 2 3
  • C6orf90 3 4
  • Chromosome 6 Open Reading Frame 90 2
  • Retinoic Acid Repressible Protein 3
  • DJ223E5.2 3
  • RARG-1 3
  • PQBP3 3
  • NOP27 4

External Ids for NOL7 Gene

Previous HGNC Symbols for NOL7 Gene

  • C6orf90
  • PQBP3

Previous GeneCards Identifiers for NOL7 Gene

  • GC06P013723

Summaries for NOL7 Gene

Entrez Gene Summary for NOL7 Gene

  • The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOL7 Gene

NOL7 (Nucleolar Protein 7) is a Protein Coding gene.

Gene Wiki entry for NOL7 Gene

Additional gene information for NOL7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL7 Gene

Genomics for NOL7 Gene

GeneHancer (GH) Regulatory Elements for NOL7 Gene

Promoters and enhancers for NOL7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J013613 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.2 200 3.5 MTA3 ZNF652 SP1 ZFX CTCF ELF3 MNT SIX5 CBFA2T2 NKRF NOL7 ENSG00000261071 RANBP9 GC06P013623 SIRT5
GH06J013394 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -218.3 -218326 10 CC2D1A ZKSCAN8 CBFA2T2 ZNF121 ZNF687 BACH1 MAFK SP7 TRIM24 CREM GFOD1 GFOD1-AS1 SIRT5 NOL7 TBC1D7 PIR51588 GC06P013360 GC06M013385
GH06J013872 Enhancer 1.1 ENCODE 10 +258.4 258361 1.7 ZNF652 ZFX CTCF ELF3 CEBPG GTF2F1 ZNF687 NFIB ZSCAN21 AHR RANBP9 NOL7 RNF182 MCUR1 PIR49028 ENSG00000272209
GH06J012941 Enhancer 0.8 Ensembl ENCODE 10.1 -670.5 -670526 7.2 PKNOX1 PRDM12 GABPA ZNF316 ZBTB11 ZC3H11A MAFK ZNF781 ZNF518A POLR2A NOL7 HIVEP1 ENSG00000272379 PHACTR1 GC06M012692 LOC105374934
GH06J013490 Enhancer 0.5 Ensembl 10.2 -124.0 -124026 1.8 ZNF623 ZFHX2 BCOR ZNF781 ZMYM3 ZNF518A NOL7 GFOD1 PIR42580
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOL7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOL7 gene promoter:
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-1
  • Msx-1
  • POU3F2
  • S8
  • Tal-1
  • Tal-1beta

Genomic Locations for NOL7 Gene

Genomic Locations for NOL7 Gene
17,413 bases
Plus strand
17,413 bases
Plus strand

Genomic View for NOL7 Gene

Genes around NOL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL7 Gene

Proteins for NOL7 Gene

  • Protein details for NOL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 7
    Protein Accession:
    Secondary Accessions:
    • Q5T297
    • Q9Y3U7

    Protein attributes for NOL7 Gene

    257 amino acids
    Molecular mass:
    29426 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB43398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL7 Gene


neXtProt entry for NOL7 Gene

Post-translational modifications for NOL7 Gene

  • Ubiquitination at isoforms=170 and posLast=210210
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOL7 Gene

Domains & Families for NOL7 Gene

Gene Families for NOL7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL7 Gene


Suggested Antigen Peptide Sequences for NOL7 Gene

GenScript: Design optimal peptide antigens:
  • Nucleolar protein of 27 kDa (NOL7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL7: view

No data available for UniProtKB/Swiss-Prot for NOL7 Gene

Function for NOL7 Gene

Phenotypes From GWAS Catalog for NOL7 Gene

Gene Ontology (GO) - Molecular Function for NOL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NOL7: view
genes like me logo Genes that share phenotypes with NOL7: view

Animal Model Products

CRISPR Products

miRNA for NOL7 Gene

miRTarBase miRNAs that target NOL7

Clone Products

  • Applied Biological Materials (abm): Clones for NOL7 - Now 50% OFF >
  • * NOL7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NOL7 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL7 Gene

Localization for NOL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL7 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL7 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Mitochondria (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IBA,IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with NOL7: view

Pathways & Interactions for NOL7 Gene

PathCards logo

SuperPathways for NOL7 Gene

No Data Available

Interacting Proteins for NOL7 Gene

Gene Ontology (GO) - Biological Process for NOL7 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOL7 Gene

Drugs & Compounds for NOL7 Gene

No Compound Related Data Available

Transcripts for NOL7 Gene

mRNA/cDNA for NOL7 Gene

Unigene Clusters for NOL7 Gene

Nucleolar protein 7, 27kDa:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NOL7 - Now 50% OFF >
  • * NOL7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NOL7 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NOL7 Gene

No ASD Table

Relevant External Links for NOL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL7 Gene

This gene is overexpressed in Stomach (22.0), Breast (20.1), and Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOL7 Gene

Protein tissue co-expression partners for NOL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOL7 Gene:


SOURCE GeneReport for Unigene cluster for NOL7 Gene:


mRNA Expression by UniProt/SwissProt for NOL7 Gene:

Tissue specificity: Expressed in numerous tissues. Particularly prevalent in the adrenal gland, thyroid gland, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for NOL7 Gene

  • Kidney(4.3)
  • Blood(3.2)
  • Nervous system(2.9)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with NOL7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL7 Gene

Orthologs for NOL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOL7 35 34
  • 99.61 (n)
(Bos Taurus)
Mammalia NOL7 35 34
  • 87.89 (n)
(Canis familiaris)
Mammalia NOL7 35 34
  • 87.19 (n)
(Mus musculus)
Mammalia Nol7 17 35 34
  • 83 (n)
(Rattus norvegicus)
Mammalia Nol7 34
  • 82.8 (n)
(Monodelphis domestica)
Mammalia NOL7 35
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia NOL7 35
  • 43 (a)
(Gallus gallus)
Aves NOL7 35 34
  • 57.42 (n)
(Anolis carolinensis)
Reptilia NOL7 35
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489073 34
  • 56.24 (n)
(Danio rerio)
Actinopterygii nol7 35 34
  • 53.14 (n)
Species where no ortholog for NOL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL7 Gene

Gene Tree for NOL7 (if available)
Gene Tree for NOL7 (if available)
Evolutionary constrained regions (ECRs) for NOL7: view image

Paralogs for NOL7 Gene

No data available for Paralogs for NOL7 Gene

Variants for NOL7 Gene

Sequence variations from dbSNP and Humsavar for NOL7 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000324763 -- 13,623,646(+) T/A/C genic_downstream_transcript_variant, intron_variant
rs1000448896 -- 13,629,095(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000480050 -- 13,629,328(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000655567 -- 13,623,413(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000702650 -- 13,617,248(+) C/G intron_variant

Variation tolerance for NOL7 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NOL7 Gene

Disorders for NOL7 Gene

Additional Disease Information for NOL7

No disorders were found for NOL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL7 Gene

Publications for NOL7 Gene

  1. NOL7 is a nucleolar candidate tumor suppressor gene in cervical cancer that modulates the angiogenic phenotype. (PMID: 16205646) Hasina R … Lingen MW (Oncogene 2006) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  5. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen JS … Lamond AI (Current biology : CB 2002) 3 4 58

Products for NOL7 Gene

Sources for NOL7 Gene

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