The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have ... See more...

Aliases for NOL7 Gene

Aliases for NOL7 Gene

  • Nucleolar Protein 7 2 3 4 5
  • Polyglutamine Binding Protein 3 2 3
  • Nucleolar Protein Of 27 KDa 3 4
  • Nucleolar Protein 7, 27kDa 2 3
  • DJ223E5.2 2 3
  • C6orf90 3 4
  • RARG-1 2 3
  • NOP27 2 4
  • Chromosome 6 Open Reading Frame 90 2
  • Retinoic Acid Repressible Protein 3
  • PQBP3 3
  • NOL7 5

External Ids for NOL7 Gene

Previous HGNC Symbols for NOL7 Gene

  • C6orf90
  • PQBP3

Previous GeneCards Identifiers for NOL7 Gene

  • GC06P013723

Summaries for NOL7 Gene

Entrez Gene Summary for NOL7 Gene

  • The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOL7 Gene

NOL7 (Nucleolar Protein 7) is a Protein Coding gene. Diseases associated with NOL7 include Renpenning Syndrome 1 and Cervix Uteri Carcinoma In Situ.

Gene Wiki entry for NOL7 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOL7 Gene

Genomics for NOL7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NOL7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOL7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOL7

Top Transcription factor binding sites by QIAGEN in the NOL7 gene promoter:
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-1
  • Msx-1
  • POU3F2
  • S8
  • Tal-1
  • Tal-1beta

Genomic Locations for NOL7 Gene

Genomic Locations for NOL7 Gene
chr6:13,615,327-13,632,739
(GRCh38/hg38)
Size:
17,413 bases
Orientation:
Plus strand
chr6:13,615,559-13,632,971
(GRCh37/hg19)
Size:
17,413 bases
Orientation:
Plus strand

Genomic View for NOL7 Gene

Genes around NOL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL7 Gene

Proteins for NOL7 Gene

  • Protein details for NOL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMY1-NOL7_HUMAN
    Recommended name:
    Nucleolar protein 7
    Protein Accession:
    Q9UMY1
    Secondary Accessions:
    • Q5T297
    • Q9Y3U7

    Protein attributes for NOL7 Gene

    Size:
    257 amino acids
    Molecular mass:
    29426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB43398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL7 Gene

Post-translational modifications for NOL7 Gene

  • Ubiquitination at Lys170 and Lys210
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOL7 Gene

Domains & Families for NOL7 Gene

Gene Families for NOL7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL7 Gene

InterPro:
Blocks:
  • NUC129
ProtoNet:

Suggested Antigen Peptide Sequences for NOL7 Gene

GenScript: Design optimal peptide antigens:
  • Nucleolar protein of 27 kDa (NOL7_HUMAN)
genes like me logo Genes that share domains with NOL7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NOL7 Gene

Function for NOL7 Gene

Phenotypes From GWAS Catalog for NOL7 Gene

Gene Ontology (GO) - Molecular Function for NOL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NOL7: view
genes like me logo Genes that share phenotypes with NOL7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOL7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL7 Gene

Localization for NOL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL7 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL7 gene
Compartment Confidence
nucleus 5
mitochondrion 3
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NOL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NOL7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NOL7 Gene

Pathways & Interactions for NOL7 Gene

PathCards logo

SuperPathways for NOL7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL7 Gene

Drugs & Compounds for NOL7 Gene

No Compound Related Data Available

Transcripts for NOL7 Gene

mRNA/cDNA for NOL7 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOL7

Alternative Splicing Database (ASD) splice patterns (SP) for NOL7 Gene

No ASD Table

Relevant External Links for NOL7 Gene

GeneLoc Exon Structure for
NOL7

Expression for NOL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL7 Gene

This gene is overexpressed in Stomach (22.0), Breast (20.1), and Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOL7 Gene



Protein tissue co-expression partners for NOL7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOL7

SOURCE GeneReport for Unigene cluster for NOL7 Gene:

Hs.306242

mRNA Expression by UniProt/SwissProt for NOL7 Gene:

Q9UMY1-NOL7_HUMAN
Tissue specificity: Expressed in numerous tissues. Particularly prevalent in the adrenal gland, thyroid gland, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for NOL7 Gene

  • Kidney(4.4)
  • Blood(3.5)
  • Nervous system(2.9)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with NOL7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL7 Gene

Orthologs for NOL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOL7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NOL7 30 31
  • 99.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NOL7 30 31
  • 87.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NOL7 30 31
  • 87.19 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nol7 30 17 31
  • 83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nol7 30
  • 82.8 (n)
Oppossum
(Monodelphis domestica)
Mammalia NOL7 31
  • 55 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NOL7 31
  • 43 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NOL7 30 31
  • 57.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NOL7 31
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100489073 30
  • 56.24 (n)
Zebrafish
(Danio rerio)
Actinopterygii nol7 30 31
  • 53.14 (n)
OneToOne
Species where no ortholog for NOL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NOL7 Gene

ENSEMBL:
Gene Tree for NOL7 (if available)
TreeFam:
Gene Tree for NOL7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOL7: view image

Paralogs for NOL7 Gene

No data available for Paralogs for NOL7 Gene

Variants for NOL7 Gene

Additional dbSNP identifiers (rs#s) for NOL7 Gene

Variation tolerance for NOL7 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for NOL7 Gene

Disorders for NOL7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NOL7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renpenning syndrome 1
  • rens1
cervix uteri carcinoma in situ
  • carcinoma in situ of cervix
uterus carcinoma in situ
- elite association - COSMIC cancer census association via MalaCards
Search NOL7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOL7

genes like me logo Genes that share disorders with NOL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOL7 Gene

Publications for NOL7 Gene

  1. NOL7 is a nucleolar candidate tumor suppressor gene in cervical cancer that modulates the angiogenic phenotype. (PMID: 16205646) Hasina R … Lingen MW (Oncogene 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4

Products for NOL7 Gene

Sources for NOL7 Gene