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Aliases for NOL6 Gene

Aliases for NOL6 Gene

  • Nucleolar Protein 6 2 3 3 5
  • Nucleolar Protein Family 6 (RNA-Associated) 2 3
  • Nucleolar Protein 6 (RNA-Associated) 2 3
  • Nucleolar RNA-Associated Protein 3 4
  • BA311H10.1 3
  • UTP22 3
  • NRAP 3
  • Nrap 4

External Ids for NOL6 Gene

Previous GeneCards Identifiers for NOL6 Gene

  • GC09M033630

Summaries for NOL6 Gene

Entrez Gene Summary for NOL6 Gene

  • The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOL6 Gene

NOL6 (Nucleolar Protein 6) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding.

Gene Wiki entry for NOL6 Gene

Additional gene information for NOL6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL6 Gene

Genomics for NOL6 Gene

GeneHancer (GH) Regulatory Elements for NOL6 Gene

Promoters and enhancers for NOL6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J033472 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 753.3 +0.4 386 2.9 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 NOL6 NFX1 TOPORS ASS1P12 SMU1 TCEA1P4 ENSG00000228352 DFFBP1 UBAP2 ENSG00000223440
GH09J033867 Enhancer 1.2 Ensembl ENCODE dbSUPER 60.2 -394.6 -394558 1.8 ZFP64 ZNF213 ZNF202 ZNF680 ZNF654 ZBTB11 CEBPB ZC3H11A REST ZNF623 GC09P034283 RNU4ATAC11P ASS1P12 NOL6 NFX1 ENSG00000228352 TCEA1P4 SMU1 UBAP2 FAM205A
GH09J033156 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.4 +311.1 311065 13.1 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 ZNF610 B4GALT1 SMU1 TOPORS NOL6 ASS1P12 ENSG00000228352 DFFBP1 NFX1 UBAP2 TCEA1P4
GH09J033075 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 32.6 +397.5 397470 2.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 SMU1 NOL6 NFX1 ASS1P12 B4GALT1 TOPORS ANXA2P2 TCEA1P4 DFFBP1 UBAP2
GH09J034162 Enhancer 0.8 ENCODE 68.3 -688.9 -688915 0.2 NFIB ZNF493 RFX5 ZNF213 ZNF138 ZNF202 ZNF680 ZBTB11 ZC3H11A CEBPB PIGO NFX1 NOL6 ENSG00000228352 UBAP2 FANCG IMPDH1P1 DCAF12 FAM205A B4GALT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOL6 gene promoter:
  • USF1
  • USF-1
  • MZF-1
  • FAC1
  • Bach2
  • Lmo2
  • AML1a
  • ARP-1
  • SEF-1 (1)
  • RFX1

Genomic Locations for NOL6 Gene

Genomic Locations for NOL6 Gene
12,591 bases
Minus strand
12,591 bases
Minus strand

Genomic View for NOL6 Gene

Genes around NOL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL6 Gene

Proteins for NOL6 Gene

  • Protein details for NOL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5T5M3
    • Q5T5M4
    • Q7L4G6
    • Q8N6I0
    • Q8TEY9
    • Q8TEZ0
    • Q8TEZ1
    • Q9H675

    Protein attributes for NOL6 Gene

    1146 amino acids
    Molecular mass:
    127593 Da
    Quaternary structure:
    • Probably associated with rRNA.
    • Sequence=AAH08298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15189.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15389.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI13312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13313.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL6 Gene


neXtProt entry for NOL6 Gene

Post-translational modifications for NOL6 Gene

  • Ubiquitination at Lys271
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL6 Gene

No data available for DME Specific Peptides for NOL6 Gene

Domains & Families for NOL6 Gene

Gene Families for NOL6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NOL6 Gene

Suggested Antigen Peptide Sequences for NOL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NRAP family.
  • Belongs to the NRAP family.
genes like me logo Genes that share domains with NOL6: view

Function for NOL6 Gene

Phenotypes From GWAS Catalog for NOL6 Gene

Gene Ontology (GO) - Molecular Function for NOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22658674
genes like me logo Genes that share ontologies with NOL6: view
genes like me logo Genes that share phenotypes with NOL6: view

Animal Model Products

miRNA for NOL6 Gene

miRTarBase miRNAs that target NOL6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL6 Gene

Localization for NOL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL6 Gene

Nucleus, nucleolus. Chromosome. Note=Localizes to condensed chromosomes in mitosis. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL6 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome ISS 11895476
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus ISS,IEA 11895476
genes like me logo Genes that share ontologies with NOL6: view

Pathways & Interactions for NOL6 Gene

genes like me logo Genes that share pathways with NOL6: view

Gene Ontology (GO) - Biological Process for NOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS,IBA --
GO:0006409 tRNA export from nucleus IBA --
genes like me logo Genes that share ontologies with NOL6: view

No data available for SIGNOR curated interactions for NOL6 Gene

Drugs & Compounds for NOL6 Gene

No Compound Related Data Available

Transcripts for NOL6 Gene

mRNA/cDNA for NOL6 Gene

Unigene Clusters for NOL6 Gene

Nucleolar protein 6 (RNA-associated):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - -
SP2: - -
SP3: - - - - - - - - - - - - - - - -

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: - - - - - - - -
SP4: -

Relevant External Links for NOL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL6 Gene

Protein differential expression in normal tissues from HIPED for NOL6 Gene

This gene is overexpressed in Nasal epithelium (39.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOL6 Gene

Protein tissue co-expression partners for NOL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL6 Gene:


SOURCE GeneReport for Unigene cluster for NOL6 Gene:


Evidence on tissue expression from TISSUES for NOL6 Gene

  • Nervous system(4.9)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with NOL6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL6 Gene

Orthologs for NOL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOL6 34 33
  • 99.51 (n)
(Canis familiaris)
Mammalia NOL6 34 33
  • 89.03 (n)
(Bos Taurus)
Mammalia NOL6 34 33
  • 87.75 (n)
(Rattus norvegicus)
Mammalia Nol6 33
  • 85.93 (n)
(Mus musculus)
Mammalia Nol6 16 34 33
  • 85.28 (n)
(Monodelphis domestica)
Mammalia NOL6 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia NOL6 34
  • 69 (a)
(Gallus gallus)
Aves NOL6 34 33
  • 63.62 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 61 (a)
-- 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nol6 33
  • 61.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3810 33
(Danio rerio)
Actinopterygii nol6 34 33
  • 57.28 (n)
wufi43b02 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003992 33
  • 48.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mat89Ba 34 33
  • 45.78 (n)
(Caenorhabditis elegans)
Secernentea nol-6 34
  • 25 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR029W 33
  • 43.2 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP22 36 34 33
  • 40.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14806g 33
  • 40.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63810 33
  • 43.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09437 33
  • 43.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC776.08c 33
  • 39.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for NOL6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOL6 Gene

Gene Tree for NOL6 (if available)
Gene Tree for NOL6 (if available)
Evolutionary constrained regions (ECRs) for NOL6: view image

Paralogs for NOL6 Gene

No data available for Paralogs for NOL6 Gene

Variants for NOL6 Gene

Sequence variations from dbSNP and Humsavar for NOL6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000063746 -- 33,461,111(-) A/C/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000306817 -- 33,472,700(-) C/T intron_variant
rs1000394347 -- 33,464,244(-) C/G intron_variant
rs1000519922 -- 33,460,940(-) G/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000553386 -- 33,465,498(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOL6 Gene

Variant ID Type Subtype PubMed ID
dgv7517n100 CNV gain 25217958
esv3576648 CNV gain 25503493
nsv1024207 CNV gain 25217958
nsv478045 CNV novel sequence insertion 20440878
nsv516500 CNV loss 19592680
nsv518168 CNV loss 19592680
nsv527128 CNV loss 19592680

Variation tolerance for NOL6 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL6 Gene

Disorders for NOL6 Gene

Additional Disease Information for NOL6

No disorders were found for NOL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL6 Gene

Publications for NOL6 Gene

  1. Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans. (PMID: 11895476) Utama B … Mattick JS (Genes to cells : devoted to molecular & cellular mechanisms 2002) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The small-subunit processome is a ribosome assembly intermediate. (PMID: 15590835) Bernstein KA … Baserga SJ (Eukaryotic cell 2004) 2 3 58

Products for NOL6 Gene

Sources for NOL6 Gene

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