Aliases for NOL4 Gene

Aliases for NOL4 Gene

  • Nucleolar Protein 4 2 3 4 5
  • NOLP 2 3 4
  • Cancer/Testis Antigen 125 2 3
  • HRIHFB2255 2 3
  • CT125 2 3
  • Nucleolar Localized Protein 3
  • Nucleolar-Localized Protein 4
  • NOL4 5

External Ids for NOL4 Gene

Previous GeneCards Identifiers for NOL4 Gene

  • GC18M031465
  • GC18M031251
  • GC18M029684
  • GC18M029686
  • GC18M028290

Summaries for NOL4 Gene

GeneCards Summary for NOL4 Gene

NOL4 (Nucleolar Protein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is NOL4L.

Gene Wiki entry for NOL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOL4 Gene

Genomics for NOL4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NOL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J034657 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 3.9 -435.2 -435230 4.8 ETS1 CTCF ZEB1 HOMEZ CEBPB SIN3A ZNF639 MAX TRIM22 MAFF DTNA NOL4 MAPRE2 piR-40110-318 HSALNG0120838 RPL10AP13 lnc-MAPRE2-4
GH18J034706 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.1 -484.5 -484499 5.1 FEZF1 CEBPA CEBPB MBD2 MAX EP300 CTBP1 RFX5 ZNF843 SMC3 DTNA MAPRE2 NOL4 piR-32214-304 HE856242 HSALNG0120839 lnc-MAPRE2-4
GH18J034221 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 0.7 +2.2 2156 5.2 ZBTB10 CTCF ZIC2 ZNF610 ZNF513 SIN3A TRIM22 ZNF341 SMC3 ZNF843 ENSG00000280406 ENSG00000267746 HSALNG0120825 lnc-CCDC178-4 NOL4 lnc-NOL4-1 ASXL3
GH18J033880 Enhancer 0.2 FANTOM5 2.4 +344.3 344280 0.4 NOL4 HSALNG0120823 piR-61532-125 ASXL3
GH18J034158 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 0.2 +65.6 65638 1.4 CTCF SIN3A ZNF341 GABPB1 BHLHE40 ZBTB48 IKZF1 BMI1 GLIS1 ZNF398 piR-47211-312 piR-40110-317 lnc-CCDC178-4 NOL4 ASXL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOL4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOL4

Top Transcription factor binding sites by QIAGEN in the NOL4 gene promoter:
  • c-Myc
  • HSF2
  • Max1
  • Meis-1
  • Meis-1a
  • MIF-1
  • Nkx2-5
  • Pax-4a
  • POU6F1 (c2)
  • S8

Genomic Locations for NOL4 Gene

Latest Assembly
chr18:33,851,100-34,224,957
(GRCh38/hg38)
Size:
373,858 bases
Orientation:
Minus strand

Previous Assembly
chr18:31,431,064-31,804,877
(GRCh37/hg19 by Entrez Gene)
Size:
373,814 bases
Orientation:
Minus strand

chr18:31,431,064-31,804,916
(GRCh37/hg19 by Ensembl)
Size:
373,853 bases
Orientation:
Minus strand

Genomic View for NOL4 Gene

Genes around NOL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL4 Gene

Proteins for NOL4 Gene

  • Protein details for NOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94818-NOL4_HUMAN
    Recommended name:
    Nucleolar protein 4
    Protein Accession:
    O94818
    Secondary Accessions:
    • B4DSQ0
    • B7Z3Z7
    • F5H1E3
    • Q6IBS2
    • Q9BWF1

    Protein attributes for NOL4 Gene

    Size:
    638 amino acids
    Molecular mass:
    71357 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH00313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL4 Gene

Post-translational modifications for NOL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOL4 Gene

Domains & Families for NOL4 Gene

Gene Families for NOL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOL4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ34144 fis, clone FCBBF3011592, highly similar to Homo sapiens nolp mRNA (B3KRF4_HUMAN)
  • cDNA FLJ56029, highly similar to Nucleolar protein 4 (B4DSQ0_HUMAN)
  • Nucleolar-localized protein (NOL4_HUMAN)
genes like me logo Genes that share domains with NOL4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NOL4 Gene

Function for NOL4 Gene

Molecular function for NOL4 Gene

GENATLAS Biochemistry:
nucleolar protein 4

Phenotypes From GWAS Catalog for NOL4 Gene

Gene Ontology (GO) - Molecular Function for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9813152
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with NOL4: view
genes like me logo Genes that share phenotypes with NOL4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOL4

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL4 Gene

Localization for NOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL4 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NOL4: view

Pathways & Interactions for NOL4 Gene

PathCards logo

SuperPathways for NOL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL4 Gene

Drugs & Compounds for NOL4 Gene

No Compound Related Data Available

Transcripts for NOL4 Gene

mRNA/cDNA for NOL4 Gene

19 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOL4

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for NOL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP3: - - - -

Relevant External Links for NOL4 Gene

GeneLoc Exon Structure for
NOL4

Expression for NOL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cerebellar Hemisphere (x4.4), Brain - Cortex (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for NOL4 Gene

This gene is overexpressed in Frontal cortex (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NOL4 Gene



Protein tissue co-expression partners for NOL4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOL4

SOURCE GeneReport for Unigene cluster for NOL4 Gene:

Hs.514795

mRNA Expression by UniProt/SwissProt for NOL4 Gene:

O94818-NOL4_HUMAN
Tissue specificity: Expressed predominantly in fetal brain, adult brain and testis.

Evidence on tissue expression from TISSUES for NOL4 Gene

  • Nervous system(4.8)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with NOL4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL4 Gene

Orthologs for NOL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NOL4 30 31
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NOL4 30 31
  • 94.88 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NOL4 30 31
  • 93.36 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NOL4 31
  • 93 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Nol4 30 17 31
  • 89.68 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nol4 30
  • 84.06 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NOL4 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NOL4 30 31
  • 88.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NOL4 31
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nol4 30
  • 80.75 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta BG:DS01523.1 32
  • 75 (a)
CG17341 31
  • 24 (a)
OneToOne
Species where no ortholog for NOL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NOL4 Gene

ENSEMBL:
Gene Tree for NOL4 (if available)
TreeFam:
Gene Tree for NOL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOL4: view image

Paralogs for NOL4 Gene

Paralogs for NOL4 Gene

(2) SIMAP similar genes for NOL4 Gene using alignment to 7 proteins:

  • NOL4_HUMAN
  • B3KRF4_HUMAN
  • K7EID6_HUMAN
  • K7EIK8_HUMAN
  • K7ENM5_HUMAN
  • K7EPC5_HUMAN
  • K7EQ17_HUMAN
genes like me logo Genes that share paralogs with NOL4: view

Variants for NOL4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NOL4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NOL4 Gene

Variant ID Type Subtype PubMed ID
dgv58n6 CNV deletion 16902084
esv1010069 CNV deletion 20482838
esv1694854 CNV deletion 17803354
esv2019786 CNV deletion 18987734
esv2663858 CNV deletion 23128226
esv2668525 CNV deletion 23128226
esv2670669 CNV deletion 23128226
esv2716952 CNV deletion 23290073
esv3222 CNV loss 18987735
esv3303199 CNV mobile element insertion 20981092
esv3348179 CNV insertion 20981092
esv3555212 CNV deletion 23714750
esv3642176 CNV loss 21293372
esv3642180 CNV loss 21293372
esv3642181 CNV loss 21293372
esv3642182 CNV loss 21293372
esv3642183 CNV loss 21293372
nsv1071450 CNV deletion 25765185
nsv1134709 CNV deletion 24896259
nsv1150892 CNV deletion 26484159
nsv132109 CNV insertion 16902084
nsv458048 CNV loss 19166990
nsv458049 CNV loss 19166990
nsv470415 CNV gain 18288195
nsv519676 CNV gain 19592680
nsv576643 CNV gain 21841781
nsv576646 CNV loss 21841781
nsv576647 CNV loss 21841781
nsv576648 CNV loss 21841781
nsv576649 CNV loss 21841781
nsv954942 CNV deletion 24416366

Variation tolerance for NOL4 Gene

Residual Variation Intolerance Score: 6.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOL4 Gene

Disorders for NOL4 Gene

Additional Disease Information for NOL4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for NOL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL4 Gene

Publications for NOL4 Gene

  1. NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization. (PMID: 9813152) Ueki N … Muramatsu M (Biochemical and biophysical research communications 1998) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. A genomewide association study of citalopram response in major depressive disorder. (PMID: 19846067) Garriock HA … Hamilton SP (Biological psychiatry 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for NOL4 Gene

Sources for NOL4 Gene