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Aliases for NOL4 Gene

Aliases for NOL4 Gene

  • Nucleolar Protein 4 2 3 3 5
  • Cancer/Testis Antigen 125 2 3
  • NOLP 3 4
  • Nucleolar Localized Protein 3
  • Nucleolar-Localized Protein 4
  • HRIHFB2255 3
  • CT125 3

External Ids for NOL4 Gene

Previous GeneCards Identifiers for NOL4 Gene

  • GC18M031465
  • GC18M031251
  • GC18M029684
  • GC18M029686
  • GC18M028290

Summaries for NOL4 Gene

GeneCards Summary for NOL4 Gene

NOL4 (Nucleolar Protein 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is NOL4L.

Gene Wiki entry for NOL4 Gene

Additional gene information for NOL4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL4 Gene

Genomics for NOL4 Gene

GeneHancer (GH) Regulatory Elements for NOL4 Gene

Promoters and enhancers for NOL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J034224 Promoter/Enhancer 1.4 Ensembl ENCODE 650.7 +0.2 180 0.9 PKNOX1 ZSCAN4 SIN3A RAD21 ZNF335 GLIS2 ZNF366 ZNF143 ATF7 IKZF2 ENSG00000278052 NOL4 ENSG00000267746
GH18J034657 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.9 -435.2 -435235 4.8 PKNOX1 SIN3A YY1 ETS1 ZNF143 FOS TSHZ1 MAFF RFX3 WT1 DTNA NOL4 MAPRE2 RPL10AP13 ENSG00000268873
GH18J034706 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.2 -484.4 -484399 4.9 PKNOX1 NFIB ZSCAN4 MZF1 FEZF1 BMI1 RFX5 ZNF366 FOS RCOR1 DTNA MAPRE2 NOL4 ENSG00000268873 RPL10AP13
GH18J034221 Enhancer 0.8 ENCODE 0.7 +2.2 2231 1.6 PKNOX1 SIN3A ZNF335 GLIS2 ZNF366 SCRT2 SP3 ZBTB11 ZNF398 GLIS1 ENSG00000280406 ENSG00000267746 NOL4
GH18J033880 Enhancer 0.2 FANTOM5 2.4 +344.3 344275 0.4 NOL4 GC18P033757 GC18M034002 ENSG00000199204
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOL4 gene promoter:
  • POU6F1 (c2)
  • MIF-1
  • Nkx2-5
  • Pax-4a
  • S8
  • c-Myc
  • Max1
  • HSF2
  • Meis-1
  • Meis-1a

Genomic Locations for NOL4 Gene

Genomic Locations for NOL4 Gene
373,853 bases
Minus strand
373,853 bases
Minus strand

Genomic View for NOL4 Gene

Genes around NOL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL4 Gene

Proteins for NOL4 Gene

  • Protein details for NOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 4
    Protein Accession:
    Secondary Accessions:
    • B4DSQ0
    • B7Z3Z7
    • F5H1E3
    • Q6IBS2
    • Q9BWF1

    Protein attributes for NOL4 Gene

    638 amino acids
    Molecular mass:
    71357 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Erroneous termination; Positions=38; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL4 Gene


neXtProt entry for NOL4 Gene

Post-translational modifications for NOL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOL4 Gene

Domains & Families for NOL4 Gene

Gene Families for NOL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL4 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL4: view

No data available for UniProtKB/Swiss-Prot for NOL4 Gene

Function for NOL4 Gene

Molecular function for NOL4 Gene

GENATLAS Biochemistry:
nucleolar protein 4

Phenotypes From GWAS Catalog for NOL4 Gene

Gene Ontology (GO) - Molecular Function for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9813152
genes like me logo Genes that share ontologies with NOL4: view
genes like me logo Genes that share phenotypes with NOL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOL4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL4 Gene

Localization for NOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL4 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL4 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NOL4: view

Pathways & Interactions for NOL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL4 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOL4 Gene

Drugs & Compounds for NOL4 Gene

No Compound Related Data Available

Transcripts for NOL4 Gene

Unigene Clusters for NOL4 Gene

Nucleolar protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOL4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP3: - - - -

Relevant External Links for NOL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cerebellar Hemisphere (x4.4), Brain - Cortex (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for NOL4 Gene

This gene is overexpressed in Frontal cortex (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NOL4 Gene

Protein tissue co-expression partners for NOL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL4 Gene:


SOURCE GeneReport for Unigene cluster for NOL4 Gene:


mRNA Expression by UniProt/SwissProt for NOL4 Gene:

Tissue specificity: Expressed predominantly in fetal brain, adult brain and testis.

Evidence on tissue expression from TISSUES for NOL4 Gene

  • Nervous system(4.8)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with NOL4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL4 Gene

Orthologs for NOL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOL4 34 33
  • 99.63 (n)
(Canis familiaris)
Mammalia NOL4 34 33
  • 94.88 (n)
(Bos Taurus)
Mammalia NOL4 34 33
  • 93.36 (n)
(Monodelphis domestica)
Mammalia NOL4 34
  • 93 (a)
(Mus musculus)
Mammalia Nol4 16 34 33
  • 89.68 (n)
(Rattus norvegicus)
Mammalia Nol4 33
  • 84.06 (n)
(Ornithorhynchus anatinus)
Mammalia NOL4 34
  • 81 (a)
(Gallus gallus)
Aves NOL4 34 33
  • 88.3 (n)
(Anolis carolinensis)
Reptilia NOL4 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nol4 33
  • 80.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS01523.1 35
  • 75 (a)
CG17341 34
  • 24 (a)
Species where no ortholog for NOL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NOL4 Gene

Gene Tree for NOL4 (if available)
Gene Tree for NOL4 (if available)
Evolutionary constrained regions (ECRs) for NOL4: view image

Paralogs for NOL4 Gene

Paralogs for NOL4 Gene

(2) SIMAP similar genes for NOL4 Gene using alignment to 7 proteins:

  • K7EQ17_HUMAN
genes like me logo Genes that share paralogs with NOL4: view

Variants for NOL4 Gene

Sequence variations from dbSNP and Humsavar for NOL4 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000009923 -- 34,013,169(-) T/A intron_variant
rs1000013499 -- 34,006,788(-) G/A intron_variant
rs1000016982 -- 34,106,217(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000024258 -- 34,064,583(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000032671 -- 34,099,009(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOL4 Gene

Variant ID Type Subtype PubMed ID
dgv58n6 CNV deletion 16902084
esv1010069 CNV deletion 20482838
esv1694854 CNV deletion 17803354
esv2019786 CNV deletion 18987734
esv2663858 CNV deletion 23128226
esv2668525 CNV deletion 23128226
esv2670669 CNV deletion 23128226
esv2716952 CNV deletion 23290073
esv3222 CNV loss 18987735
esv3303199 CNV mobile element insertion 20981092
esv3348179 CNV insertion 20981092
esv3555212 CNV deletion 23714750
esv3642176 CNV loss 21293372
esv3642180 CNV loss 21293372
esv3642181 CNV loss 21293372
esv3642182 CNV loss 21293372
esv3642183 CNV loss 21293372
nsv1071450 CNV deletion 25765185
nsv1134709 CNV deletion 24896259
nsv1150892 CNV deletion 26484159
nsv132109 CNV insertion 16902084
nsv458048 CNV loss 19166990
nsv458049 CNV loss 19166990
nsv470415 CNV gain 18288195
nsv519676 CNV gain 19592680
nsv576643 CNV gain 21841781
nsv576646 CNV loss 21841781
nsv576647 CNV loss 21841781
nsv576648 CNV loss 21841781
nsv576649 CNV loss 21841781
nsv954942 CNV deletion 24416366

Variation tolerance for NOL4 Gene

Residual Variation Intolerance Score: 6.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL4 Gene

Disorders for NOL4 Gene

Additional Disease Information for NOL4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NOL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL4 Gene

Publications for NOL4 Gene

  1. NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization. (PMID: 9813152) Ueki N … Muramatsu M (Biochemical and biophysical research communications 1998) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. A genomewide association study of citalopram response in major depressive disorder. (PMID: 19846067) Garriock HA … Hamilton SP (Biological psychiatry 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NOL4 Gene

Sources for NOL4 Gene

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