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Aliases for NOL12 Gene

Aliases for NOL12 Gene

  • Nucleolar Protein 12 2 3 5
  • DJ37E16.7 3
  • Nop25 3

External Ids for NOL12 Gene

Previous GeneCards Identifiers for NOL12 Gene

  • GC22P036412
  • GC22P038077
  • GC22P021049
  • GC22P038082

Summaries for NOL12 Gene

GeneCards Summary for NOL12 Gene

NOL12 (Nucleolar Protein 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include rRNA binding. An important paralog of this gene is ENSG00000100101.

UniProtKB/Swiss-Prot for NOL12 Gene

  • May bind to 28S rRNA.

Gene Wiki entry for NOL12 Gene

Additional gene information for NOL12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL12 Gene

Genomics for NOL12 Gene

GeneHancer (GH) Regulatory Elements for NOL12 Gene

Promoters and enhancers for NOL12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I037683 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +4.1 4087 3.7 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 ENSG00000100101 NOL12 ENSG00000230912 CSNK1E CBY1 TRIOBP ANKRD54 ENSG00000228274 DDX17 FAM227A
GH22I037679 Enhancer 1 Ensembl ENCODE 550.8 -0.8 -780 2.8 HDGF HDAC1 ZSCAN4 ARID4B ZNF76 SIN3A KLF5 IRF4 THRB RAD21 NOL12 LOC101927051 SH3BP1 ENSG00000100101 NCF4-AS1 PLA2G6 LGALS1 GC22P037676 GC22P037677
GH22I037227 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2 -445.0 -444966 18.7 HDGF PKNOX1 SMAD1 ARNT POLR2B E2F8 ZNF207 ZNF143 FOS REST RAC2 CYTH4 GGA1 CSF2RB SSTR3 C1QTNF6 NCF4 SH3BP1 ENSG00000226233 MFNG
GH22I037281 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.1 -397.9 -397888 4.3 HDGF IRF4 ZNF143 ATF7 ETV6 IKZF2 RUNX3 SMARCA5 ELF1 ZNF217 CYTH4 CSF2RB GGA1 NCF4 RAC2 LGALS2 SH3BP1 RPS15AP38 MFNG NOL12
GH22I037625 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -54.5 -54458 3.5 HDGF ZBTB6 EBF1 ZIC2 RAD21 RELA POLR2A SCRT2 HNF4G ETV6 SH3BP1 CYTH4 GGA1 RAC2 NOL12 PIR54932 PIR52381
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOL12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOL12 gene promoter:

Genomic Locations for NOL12 Gene

Genomic Locations for NOL12 Gene
11,806 bases
Plus strand

Genomic View for NOL12 Gene

Genes around NOL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL12 Gene

Proteins for NOL12 Gene

  • Protein details for NOL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 12
    Protein Accession:

    Protein attributes for NOL12 Gene

    213 amino acids
    Molecular mass:
    24663 Da
    Quaternary structure:
    • Interacts with KIAA1191.

neXtProt entry for NOL12 Gene

Post-translational modifications for NOL12 Gene

No Post-translational modifications

Other Protein References for NOL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOL12 Gene

Domains & Families for NOL12 Gene

Gene Families for NOL12 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL12 Gene


Suggested Antigen Peptide Sequences for NOL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP17 family.
  • Belongs to the RRP17 family.
genes like me logo Genes that share domains with NOL12: view

Function for NOL12 Gene

Molecular function for NOL12 Gene

UniProtKB/Swiss-Prot Function:
May bind to 28S rRNA.

Phenotypes From GWAS Catalog for NOL12 Gene

Gene Ontology (GO) - Molecular Function for NOL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 21044950
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with NOL12: view
genes like me logo Genes that share phenotypes with NOL12: view

Animal Model Products

miRNA for NOL12 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL12 Gene

Localization for NOL12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL12 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL12 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NOL12: view

Pathways & Interactions for NOL12 Gene

SuperPathways for NOL12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL12 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOL12 Gene

Drugs & Compounds for NOL12 Gene

No Compound Related Data Available

Transcripts for NOL12 Gene

Unigene Clusters for NOL12 Gene

Nucleolar protein 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL12 Gene

No ASD Table

Relevant External Links for NOL12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL12 Gene

This gene is overexpressed in Lung (44.4) and Adrenal (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL12 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOL12 Gene:


SOURCE GeneReport for Unigene cluster for NOL12 Gene:


Evidence on tissue expression from TISSUES for NOL12 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with NOL12: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL12 Gene

Orthologs for NOL12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOL12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOL12 33
  • 98.75 (n)
(Bos Taurus)
Mammalia NOL12 33
  • 88.99 (n)
(Canis familiaris)
Mammalia NOL12 33
  • 88.58 (n)
(Mus musculus)
Mammalia Nol12 33 16
  • 86.23 (n)
(Rattus norvegicus)
Mammalia Nol12 33
  • 85.29 (n)
(Gallus gallus)
Aves NOL12 33
  • 67.32 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nol12 33
  • 59.74 (n)
Str.879 33
(Danio rerio)
Actinopterygii nol12 33
  • 61.2 (n)
zgc56457 33
Species where no ortholog for NOL12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL12 Gene

Gene Tree for NOL12 (if available)
Gene Tree for NOL12 (if available)

Paralogs for NOL12 Gene

Paralogs for NOL12 Gene

genes like me logo Genes that share paralogs with NOL12: view

Variants for NOL12 Gene

Sequence variations from dbSNP and Humsavar for NOL12 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000819859 -- 37,690,157(+) G/A intron_variant
rs1000875917 -- 37,686,765(+) C/T intron_variant
rs1000890775 -- 37,690,451(+) T/C intron_variant
rs1001241854 -- 37,685,460(+) A/C upstream_transcript_variant
rs1001640954 -- 37,686,268(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NOL12 Gene

Variant ID Type Subtype PubMed ID
nsv834191 CNV loss 17160897
nsv829203 CNV loss 20364138
nsv528985 CNV loss 19592680
nsv471197 CNV loss 18288195
nsv1057617 CNV gain 25217958
esv3647715 CNV loss 21293372
esv2758838 CNV loss 17122850

Variation tolerance for NOL12 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL12 Gene

Disorders for NOL12 Gene

Additional Disease Information for NOL12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NOL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL12 Gene

Publications for NOL12 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins JE … Dunham I (Genome research 2003) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58

Products for NOL12 Gene

Sources for NOL12 Gene

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