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Aliases for NOL11 Gene

Aliases for NOL11 Gene

  • Nucleolar Protein 11 2 3 5

External Ids for NOL11 Gene

Previous GeneCards Identifiers for NOL11 Gene

  • GC17P063145
  • GC17P065714
  • GC17P061098

Summaries for NOL11 Gene

GeneCards Summary for NOL11 Gene

NOL11 (Nucleolar Protein 11) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol.

UniProtKB/Swiss-Prot for NOL11 Gene

  • Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A, A0, 1 and 2b.

Additional gene information for NOL11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL11 Gene

Genomics for NOL11 Gene

GeneHancer (GH) Regulatory Elements for NOL11 Gene

Promoters and enhancers for NOL11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I067716 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.5 +0.0 44 3.1 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NOL11 LOC101928045 BPTF HELZ WIPI1 GC17P067742
GH17I067717 Enhancer 0.5 ENCODE 550.8 -1.7 -1653 0.2 HDGF CEBPA NBN ZBTB33 MLLT1 IKZF2 LOC101928045 NOL11 GC17P067695
GH17I068508 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 81.2 +794.5 794519 6.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF548 SP3 PRKAR1A NOL11 BPTF ABCA9 ABCA10 SNRPGP4 ENSG00000267731 WIPI1 SLC16A6 GC17P068532
GH17I067438 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 97.7 -276.1 -276055 6.4 PKNOX1 FOXA2 ZNF529 ZFP64 MZF1 ZNF121 ZNF213 ZNF354C ZNF138 RCOR1 BPTF NOL11 HELZ LOC100418928 ENSG00000267731 MIR548AA2 MIR548D2 PITPNC1 SLC16A6 RN7SL756P
GH17I067992 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 63.9 +277.0 276961 4.5 CLOCK ZFP64 YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 C17orf58 NOL11 HELZ BPTF LRRC37A16P ENSG00000265055 ENSG00000267731 LOC100418928 ENSG00000265100 WIPI1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOL11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOL11 gene promoter:

Genomic Locations for NOL11 Gene

Genomic Locations for NOL11 Gene
26,699 bases
Plus strand

Genomic View for NOL11 Gene

Genes around NOL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL11 Gene

Proteins for NOL11 Gene

  • Protein details for NOL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 11
    Protein Accession:
    Secondary Accessions:
    • B7Z5V9
    • Q7L5S1
    • Q9UG18

    Protein attributes for NOL11 Gene

    719 amino acids
    Molecular mass:
    81124 Da
    Quaternary structure:
    • Interacts with UTP4. Interacts with FBL/fibrillarin in a transcription-dependent manner (PubMed:22916032). May associate with the proposed t-UTP subcomplex of the SSU processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.
    • Is the likely candidate for being the functional analog of yeast Utp8.
    • Sequence=BAH13045.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAB53709.1; Type=Frameshift; Positions=382, 383; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL11 Gene


neXtProt entry for NOL11 Gene

Post-translational modifications for NOL11 Gene

  • Ubiquitination at Lys52, isoforms=2125, Lys252, Lys344, Lys424, and Lys676
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL11 Gene

No data available for DME Specific Peptides for NOL11 Gene

Domains & Families for NOL11 Gene

Gene Families for NOL11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL11 Gene

Suggested Antigen Peptide Sequences for NOL11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL11: view

No data available for UniProtKB/Swiss-Prot for NOL11 Gene

Function for NOL11 Gene

Molecular function for NOL11 Gene

UniProtKB/Swiss-Prot Function:
Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A, A0, 1 and 2b.

Phenotypes From GWAS Catalog for NOL11 Gene

Gene Ontology (GO) - Molecular Function for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 22916032
genes like me logo Genes that share ontologies with NOL11: view
genes like me logo Genes that share phenotypes with NOL11: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL11 Gene

Localization for NOL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL11 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL11 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 22916032
GO:0034455 t-UTP complex IDA 22916032
genes like me logo Genes that share ontologies with NOL11: view

Pathways & Interactions for NOL11 Gene

genes like me logo Genes that share pathways with NOL11: view

Gene Ontology (GO) - Biological Process for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006364 rRNA processing TAS --
GO:0030490 maturation of SSU-rRNA IMP 22916032
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with NOL11: view

No data available for SIGNOR curated interactions for NOL11 Gene

Drugs & Compounds for NOL11 Gene

No Compound Related Data Available

Transcripts for NOL11 Gene

Unigene Clusters for NOL11 Gene

Nucleolar protein 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for NOL11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL11 Gene

Protein differential expression in normal tissues from HIPED for NOL11 Gene

This gene is overexpressed in Breast (25.9), CD8 Tcells (7.1), Peripheral blood mononuclear cells (6.7), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL11 Gene

Protein tissue co-expression partners for NOL11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL11 Gene:


SOURCE GeneReport for Unigene cluster for NOL11 Gene:


Evidence on tissue expression from TISSUES for NOL11 Gene

  • Nervous system(4.9)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with NOL11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL11 Gene

Orthologs for NOL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOL11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOL11 33 34
  • 99.63 (n)
(Canis familiaris)
Mammalia NOL11 34 33
  • 88.22 (n)
(Bos Taurus)
Mammalia NOL11 33 34
  • 86.58 (n)
(Mus musculus)
Mammalia Nol11 33 16 34
  • 80.56 (n)
(Rattus norvegicus)
Mammalia Nol11 33
  • 78.38 (n)
(Monodelphis domestica)
Mammalia NOL11 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia NOL11 34
  • 60 (a)
(Gallus gallus)
Aves LOC100859426 33
  • 64.63 (n)
NOL11 34 34
  • 53 (a)
(Anolis carolinensis)
Reptilia NOL11 34
  • 51 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15994 33
(Danio rerio)
Actinopterygii nol11 33 34
  • 52.55 (n)
Species where no ortholog for NOL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL11 Gene

Gene Tree for NOL11 (if available)
Gene Tree for NOL11 (if available)

Paralogs for NOL11 Gene Pseudogenes for NOL11 Gene

genes like me logo Genes that share paralogs with NOL11: view

No data available for Paralogs for NOL11 Gene

Variants for NOL11 Gene

Sequence variations from dbSNP and Humsavar for NOL11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000004451 -- 67,739,332(+) C/T intron_variant
rs1000037729 -- 67,735,196(+) G/A intron_variant
rs1000120857 -- 67,724,258(+) T/C intron_variant
rs1000138067 -- 67,729,276(+) C/G intron_variant
rs1000254915 -- 67,724,488(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOL11 Gene

Variant ID Type Subtype PubMed ID
dgv1499n106 CNV deletion 24896259
esv1406871 CNV deletion 17803354
esv2209241 CNV deletion 18987734
esv2556372 CNV deletion 19546169
esv3554684 CNV deletion 23714750
esv3806 CNV loss 18987735
esv3893036 CNV gain 25118596
esv7392 CNV loss 19470904
nsv1066511 CNV gain 25217958
nsv1071400 CNV deletion 25765185
nsv1120054 OTHER inversion 24896259
nsv1146861 CNV deletion 26484159
nsv510442 OTHER sequence alteration 20534489
nsv511059 OTHER complex 20534489
nsv575915 CNV gain 21841781
nsv955416 CNV deletion 24416366

Variation tolerance for NOL11 Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL11 Gene

Disorders for NOL11 Gene

Additional Disease Information for NOL11

No disorders were found for NOL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL11 Gene

Publications for NOL11 Gene

  1. NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. (PMID: 22916032) Freed EF … Baserga SJ (PLoS genetics 2012) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J … Carter P (Oncogene 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for NOL11 Gene

Sources for NOL11 Gene

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