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Aliases for NOL10 Gene

Aliases for NOL10 Gene

  • Nucleolar Protein 10 2 3 5
  • Polyglutamine Binding Protein 5 2 3
  • H_NH0074G24.1 3
  • PQBP5 3

External Ids for NOL10 Gene

Previous HGNC Symbols for NOL10 Gene

  • PQBP5

Summaries for NOL10 Gene

GeneCards Summary for NOL10 Gene

NOL10 (Nucleolar Protein 10) is a Protein Coding gene.

Additional gene information for NOL10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL10 Gene

Genomics for NOL10 Gene

GeneHancer (GH) Regulatory Elements for NOL10 Gene

Promoters and enhancers for NOL10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I010688 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 70 2.2 HDGF CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RN7SL832P ENSG00000277446 NOL10 TAF1B GC02P010687
GH02I010583 Enhancer 1.2 Ensembl ENCODE dbSUPER 41.4 +104.9 104894 2.4 SOX13 FOXA2 GATA3 RERE FOSL2 NR2F6 FOS CREM HMG20B RFX1 NOL10 ENSG00000234818 LOC105373426
GH02I010574 Enhancer 0.8 ENCODE dbSUPER 51.6 +113.8 113837 2.9 ZNF639 SP3 ZNF362 JUN ZNF140 FEZF1 TSHZ1 EP300 FOSL1 JUND NOL10 RN7SL832P TAF1B LOC101929882 ENSG00000234818 LOC105373426
GH02I010429 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +257.1 257127 5.8 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A YBX1 FEZF1 ZBTB7B TAF1B LOC101929882 KLF11 NOL10 C2orf48 ENSG00000217258 YWHAQ ENSG00000239300 CYS1 ENSG00000233502
GH02I010041 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.4 +646.2 646215 4.4 PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 E2F8 LOC101929882 KLF11 ENSG00000233502 NOL10 TAF1B ENSG00000239300 GRHL1 ENSG00000271787
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOL10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOL10 gene promoter:

Genomic Locations for NOL10 Gene

Genomic Locations for NOL10 Gene
chr2:10,570,766-10,689,987
(GRCh38/hg38)
Size:
119,222 bases
Orientation:
Minus strand
chr2:10,710,892-10,830,112
(GRCh37/hg19)

Genomic View for NOL10 Gene

Genes around NOL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL10 Gene

Proteins for NOL10 Gene

  • Protein details for NOL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSC4-NOL10_HUMAN
    Recommended name:
    Nucleolar protein 10
    Protein Accession:
    Q9BSC4
    Secondary Accessions:
    • A8K3R5
    • B4DLV0
    • Q53RC9
    • Q96TA5
    • Q9H7Y7
    • Q9H855

    Protein attributes for NOL10 Gene

    Size:
    688 amino acids
    Molecular mass:
    80302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL10 Gene

Post-translational modifications for NOL10 Gene

No data available for DME Specific Peptides for NOL10 Gene

Domains & Families for NOL10 Gene

Gene Families for NOL10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL10 Gene

Suggested Antigen Peptide Sequences for NOL10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSC4

UniProtKB/Swiss-Prot:

NOL10_HUMAN :
  • Belongs to the WD repeat NOL10/ENP2 family.
Family:
  • Belongs to the WD repeat NOL10/ENP2 family.
genes like me logo Genes that share domains with NOL10: view

Function for NOL10 Gene

Phenotypes From GWAS Catalog for NOL10 Gene

Gene Ontology (GO) - Molecular Function for NOL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NOL10: view
genes like me logo Genes that share phenotypes with NOL10: view

Animal Model Products

miRNA for NOL10 Gene

miRTarBase miRNAs that target NOL10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL10 Gene

Localization for NOL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL10 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL10 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,IDA --
genes like me logo Genes that share ontologies with NOL10: view

Pathways & Interactions for NOL10 Gene

SuperPathways for NOL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL10 Gene

Drugs & Compounds for NOL10 Gene

No Compound Related Data Available

Transcripts for NOL10 Gene

Unigene Clusters for NOL10 Gene

Nucleolar protein 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for NOL10 Gene

GeneLoc Exon Structure for
NOL10
ECgene alternative splicing isoforms for
NOL10

Expression for NOL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL10 Gene

Protein differential expression in normal tissues from HIPED for NOL10 Gene

This gene is overexpressed in Colon muscle (25.0), Peripheral blood mononuclear cells (10.7), Blymphocyte (9.9), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL10 Gene



Protein tissue co-expression partners for NOL10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL10 Gene:

NOL10

SOURCE GeneReport for Unigene cluster for NOL10 Gene:

Hs.222494

Evidence on tissue expression from TISSUES for NOL10 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with NOL10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL10 Gene

Orthologs for NOL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL10 33 34
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia NOL10 33 34
  • 92.34 (n)
oppossum
(Monodelphis domestica)
Mammalia NOL10 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOL10 33 34
  • 90.12 (n)
rat
(Rattus norvegicus)
Mammalia Nol10 33
  • 88.91 (n)
mouse
(Mus musculus)
Mammalia Nol10 33 16 34
  • 88.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOL10 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOL10 33 34
  • 78.83 (n)
lizard
(Anolis carolinensis)
Reptilia NOL10 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nol10 33
  • 73.62 (n)
Str.1457 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69094 33
zebrafish
(Danio rerio)
Actinopterygii nol10 33 34
  • 66.18 (n)
zgc55626 33
fruit fly
(Drosophila melanogaster)
Insecta l(2)34Fd 33 34
  • 54.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008159 33
  • 24.42 (n)
worm
(Caenorhabditis elegans)
Secernentea nol-10 33 34
  • 51.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENP2 33 34
  • 54.68 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04653g 33
  • 51.34 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR468W 33
  • 48.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EDA7 33
  • 53.9 (n)
rice
(Oryza sativa)
Liliopsida Os06g0128400 33
  • 52.83 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC330.09 33
  • 57.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03961 33
  • 49.31 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8724 33
Species where no ortholog for NOL10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOL10 Gene

ENSEMBL:
Gene Tree for NOL10 (if available)
TreeFam:
Gene Tree for NOL10 (if available)

Paralogs for NOL10 Gene

No data available for Paralogs for NOL10 Gene

Variants for NOL10 Gene

Sequence variations from dbSNP and Humsavar for NOL10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000004395 -- 10,597,625(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000005088 -- 10,635,902(-) T/C intron_variant
rs1000062597 -- 10,586,802(-) CTTATCTTAT/CTTAT genic_downstream_transcript_variant, intron_variant
rs1000081486 -- 10,611,656(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000115025 -- 10,666,415(-) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOL10 Gene

Variant ID Type Subtype PubMed ID
nsv833381 CNV loss 17160897
nsv833370 CNV gain 17160897
nsv828352 CNV gain 20364138
nsv828341 CNV loss 20364138
nsv472965 CNV novel sequence insertion 20440878
nsv1160568 CNV deletion 26073780
nsv1131449 CNV deletion 24896259
nsv1007185 CNV gain 25217958
nsv1000731 CNV gain 25217958
esv3589805 CNV loss 21293372
esv2866236 CNV insertion 24192839

Variation tolerance for NOL10 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL10 Gene

Disorders for NOL10 Gene

Additional Disease Information for NOL10

No disorders were found for NOL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL10 Gene

Publications for NOL10 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58

Products for NOL10 Gene

Sources for NOL10 Gene

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