Aliases for NOD1 Gene
- Nucleotide Binding Oligomerization Domain Containing 1 2 3 5
- Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 1 2 3
- Nucleotide-Binding Oligomerization Domain-Containing Protein 1 3 4
- Caspase Recruitment Domain-Containing Protein 4 3 4
- Caspase Recruitment Domain Family, Member 4 2 3
External Ids for NOD1 Gene
Previous HGNC Symbols for NOD1 Gene
Previous GeneCards Identifiers for NOD1 Gene
This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]
GeneCards Summary for NOD1 Gene
NOD1 (Nucleotide Binding Oligomerization Domain Containing 1) is a Protein Coding gene. Diseases associated with NOD1 include Helicobacter Pylori Infection and Inflammatory Bowel Disease. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Ovarian tumor domain proteases. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is NOD2.
UniProtKB/Swiss-Prot Summary for NOD1 Gene
Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.