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Aliases for NOCT Gene

Aliases for NOCT Gene

  • Nocturnin 2 3 3 5
  • CCR4-Like (Carbon Catabolite Repression 4, S.Cerevisiae) 2 3
  • Carbon Catabolite Repression 4-Like Protein 3 4
  • Circadian Deadenylase NOC 3 4
  • CCRN4L 3 4
  • NOC 3 4
  • CCR4 Carbon Catabolite Repression 4-Like (S. Cerevisiae) 2
  • CCR4 Carbon Catabolite Repression 4-Like 3
  • CCR4 Protein Homolog 3
  • EC 3.1.13.4 4
  • CCR4L 3
  • Ccr4c 3
  • CCR4 4

External Ids for NOCT Gene

Previous HGNC Symbols for NOCT Gene

  • CCRN4L

Summaries for NOCT Gene

Entrez Gene Summary for NOCT Gene

  • The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOCT Gene

NOCT (Nocturnin) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation and Circadian rythm related genes. An important paralog of this gene is ANGEL1.

UniProtKB/Swiss-Prot for NOCT Gene

  • Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

Additional gene information for NOCT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOCT Gene

Genomics for NOCT Gene

GeneHancer (GH) Regulatory Elements for NOCT Gene

Promoters and enhancers for NOCT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I139013 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -199 4.1 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 NOCT ELF2 LOC101927490 LOC105377448
GH04I139175 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.3 +161.6 161605 3.8 PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ELF2 NOCT NDUFC1 RAB33B GC04P139173 GC04P139186
GH04I139188 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +173.2 173157 1.8 HDGF PKNOX1 TCF12 POLR2B ATF7 NCOA1 MAFF GMEB1 SMARCA4 ZNF184 NOCT PPP1R14BP3 MGARP RNU6-1074P ELF2 RAB33B RN7SL311P GC04P139201 GC04P139173
GH04I139081 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 12.6 +68.0 67988 4.4 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC ELF2 NAA15 NOCT ENSG00000273247 LOC105377448 MGARP RAB33B H3F3AP6 GC04P139099 RNU6-531P
GH04I138967 Enhancer 1.1 Ensembl ENCODE 11 -48.1 -48116 1.1 PKNOX1 FOXA2 SMAD1 ARID4B IRF4 ETS1 YY1 ATF7 FOS RXRA LOC105377448 NOCT RAB33B ENSG00000273247 GC04P138943
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOCT on UCSC Golden Path with GeneCards custom track

Genomic Locations for NOCT Gene

Genomic Locations for NOCT Gene
chr4:139,015,759-139,045,939
(GRCh38/hg38)
Size:
30,181 bases
Orientation:
Plus strand
chr4:139,936,943-139,967,093
(GRCh37/hg19)

Genomic View for NOCT Gene

Genes around NOCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOCT Gene

Proteins for NOCT Gene

  • Protein details for NOCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK39-NOCT_HUMAN
    Recommended name:
    Nocturnin
    Protein Accession:
    Q9UK39
    Secondary Accessions:
    • D3DNY5
    • Q14D51
    • Q9HD93
    • Q9HD94
    • Q9HD95

    Protein attributes for NOCT Gene

    Size:
    431 amino acids
    Molecular mass:
    48196 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PPARG.

neXtProt entry for NOCT Gene

Post-translational modifications for NOCT Gene

No Post-translational modifications

Other Protein References for NOCT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOCT Gene

Domains & Families for NOCT Gene

Gene Families for NOCT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NOCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK39

UniProtKB/Swiss-Prot:

NOCT_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with NOCT: view

Function for NOCT Gene

Molecular function for NOCT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function:
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

Enzyme Numbers (IUBMB) for NOCT Gene

Gene Ontology (GO) - Molecular Function for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity TAS 10521507
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding ISS,IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with NOCT: view
genes like me logo Genes that share phenotypes with NOCT: view

Animal Models for NOCT Gene

MGI Knock Outs for NOCT:

Animal Model Products

miRNA for NOCT Gene

miRTarBase miRNAs that target NOCT

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOCT Gene

Localization for NOCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOCT Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOCT gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus ISS,TAS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with NOCT: view

Pathways & Interactions for NOCT Gene

genes like me logo Genes that share pathways with NOCT: view

Pathways by source for NOCT Gene

1 BioSystems pathway for NOCT Gene
1 Qiagen pathway for NOCT Gene

Gene Ontology (GO) - Biological Process for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 10521507
GO:0006397 mRNA processing IEA --
GO:0007623 circadian rhythm TAS --
genes like me logo Genes that share ontologies with NOCT: view

No data available for SIGNOR curated interactions for NOCT Gene

Drugs & Compounds for NOCT Gene

No Compound Related Data Available

Transcripts for NOCT Gene

mRNA/cDNA for NOCT Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOCT Gene

No ASD Table

Relevant External Links for NOCT Gene

GeneLoc Exon Structure for
NOCT
ECgene alternative splicing isoforms for
NOCT

Expression for NOCT Gene

NURSA nuclear receptor signaling pathways regulating expression of NOCT Gene:

NOCT

mRNA Expression by UniProt/SwissProt for NOCT Gene:

Q9UK39-NOCT_HUMAN
Tissue specificity: Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.

Evidence on tissue expression from TISSUES for NOCT Gene

  • Muscle(3.7)
  • Liver(2.3)
  • Nervous system(2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOCT Gene

Orthologs for NOCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOCT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCRN4L 34 33
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCRN4L 33 34
  • 89.78 (n)
rat
(Rattus norvegicus)
Mammalia Ccrn4l 33
  • 85.87 (n)
cow
(Bos Taurus)
Mammalia CCRN4L 33 34
  • 85.76 (n)
mouse
(Mus musculus)
Mammalia Ccrn4l 33 34
  • 85.3 (n)
Noct 16
oppossum
(Monodelphis domestica)
Mammalia CCRN4L 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCRN4L 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MNOC 34
  • 84 (a)
OneToOne
CCRN4L 33
  • 76.09 (n)
lizard
(Anolis carolinensis)
Reptilia CCRN4L 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccrn4l 33
  • 73.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia ccrn4l-A 33
zebrafish
(Danio rerio)
Actinopterygii CCRN4L (2 of 2) 34
  • 65 (a)
OneToMany
ccrn4la 34
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13994 33
fruit fly
(Drosophila melanogaster)
Insecta cu 33 34
  • 53.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009893 33
  • 51.99 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 34
  • 13 (a)
OneToMany
Species where no ortholog for NOCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOCT Gene

ENSEMBL:
Gene Tree for NOCT (if available)
TreeFam:
Gene Tree for NOCT (if available)

Paralogs for NOCT Gene

Paralogs for NOCT Gene

Pseudogenes.org Pseudogenes for NOCT Gene

genes like me logo Genes that share paralogs with NOCT: view

Variants for NOCT Gene

Sequence variations from dbSNP and Humsavar for NOCT Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000016577 -- 139,026,721(+) T/C intron_variant
rs1000030192 -- 139,033,309(+) G/A intron_variant
rs1000053783 -- 139,027,594(+) G/T intron_variant
rs1000361355 -- 139,039,335(+) A/G intron_variant
rs1000437551 -- 139,046,354(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NOCT Gene

Variant ID Type Subtype PubMed ID
nsv956378 CNV deletion 24416366
nsv1151552 CNV deletion 26484159
nsv1126043 CNV deletion 24896259
nsv1073374 CNV deletion 25765185
esv3602431 CNV loss 21293372
esv3564713 CNV deletion 23714750
esv2728425 CNV deletion 23290073
esv2544225 CNV deletion 19546169
esv2040934 CNV deletion 18987734
esv1464767 CNV deletion 17803354

Variation tolerance for NOCT Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOCT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOCT Gene

Disorders for NOCT Gene

Additional Disease Information for NOCT

No disorders were found for NOCT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOCT Gene

Publications for NOCT Gene

  1. Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion. (PMID: 10521507) Dupressoir A … Heidmann T (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. (PMID: 11394964) Wang Y … Besharse JC (BMC developmental biology 2001) 2 3 22 58
  3. CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter. (PMID: 18587630) Li R … Cao JM (Molecular and cellular biochemistry 2008) 3 22 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for NOCT Gene

Sources for NOCT Gene

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