The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmici... See more...

Aliases for NOCT Gene

Aliases for NOCT Gene

  • Nocturnin 2 3 4 5
  • NOC 2 3 4
  • CCR4-Like (Carbon Catabolite Repression 4, S.Cerevisiae) 2 3
  • Carbon Catabolite Repression 4-Like Protein 3 4
  • CCRN4L 3 4
  • CCR4L 2 3
  • Ccr4c 2 3
  • CCR4 Carbon Catabolite Repression 4-Like (S. Cerevisiae) 2
  • CCR4 Carbon Catabolite Repression 4-Like 3
  • Circadian Deadenylase NOC 3
  • CCR4 Protein Homolog 3
  • EC 3.1.3.- 4
  • NOCT 5
  • CCR4 4

External Ids for NOCT Gene

Previous HGNC Symbols for NOCT Gene

  • CCRN4L

Summaries for NOCT Gene

Entrez Gene Summary for NOCT Gene

  • The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOCT Gene

NOCT (Nocturnin) is a Protein Coding gene. Among its related pathways are Circadian rythm related genes and BMAL1-CLOCK,NPAS2 activates circadian gene expression. An important paralog of this gene is PDE12.

UniProtKB/Swiss-Prot Summary for NOCT Gene

  • Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOCT Gene

Genomics for NOCT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NOCT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOCT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOCT

Genomic Locations for NOCT Gene

Genomic Locations for NOCT Gene
chr4:139,015,781-139,045,939
(GRCh38/hg38)
Size:
30,159 bases
Orientation:
Plus strand
chr4:139,936,943-139,967,093
(GRCh37/hg19)
Size:
30,151 bases
Orientation:
Plus strand

Genomic View for NOCT Gene

Genes around NOCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOCT Gene

Proteins for NOCT Gene

  • Protein details for NOCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK39-NOCT_HUMAN
    Recommended name:
    Nocturnin
    Protein Accession:
    Q9UK39
    Secondary Accessions:
    • D3DNY5
    • Q14D51
    • Q9HD93
    • Q9HD94
    • Q9HD95

    Protein attributes for NOCT Gene

    Size:
    431 amino acids
    Molecular mass:
    48196 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PPARG.

    Three dimensional structures from OCA and Proteopedia for NOCT Gene

neXtProt entry for NOCT Gene

Post-translational modifications for NOCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOCT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOCT Gene

Domains & Families for NOCT Gene

Gene Families for NOCT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NOCT Gene

GenScript: Design optimal peptide antigens:
  • CCR4 protein homolog (NOCT_HUMAN)
  • CCRN4L protein (Q8WTX0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UK39

UniProtKB/Swiss-Prot:

NOCT_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with NOCT: view

Function for NOCT Gene

Molecular function for NOCT Gene

UniProtKB/Swiss-Prot Function:
Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + NADP(+) = NAD(+) + phosphate; Xref=Rhea:RHEA:28050, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:58349; Evidence={ECO:0000269|PubMed:31147539};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + NADPH = NADH + phosphate; Xref=Rhea:RHEA:60664, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:31147539};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=173 uM for NADPH {ECO:0000269|PubMed:31147539};

Enzyme Numbers (IUBMB) for NOCT Gene

Phenotypes From GWAS Catalog for NOCT Gene

Gene Ontology (GO) - Molecular Function for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity IBA 21873635
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IEA,ISS --
GO:0004535 poly(A)-specific ribonuclease activity IEA,ISS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NOCT: view
genes like me logo Genes that share phenotypes with NOCT: view

Animal Models for NOCT Gene

MGI Knock Outs for NOCT:

Animal Model Products

  • Taconic Biosciences Mouse Models for NOCT

CRISPR Products

miRNA for NOCT Gene

miRTarBase miRNAs that target NOCT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOCT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOCT Gene

Localization for NOCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOCT Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOCT gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus TAS,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion IEA,IDA 31147539
genes like me logo Genes that share ontologies with NOCT: view

Pathways & Interactions for NOCT Gene

genes like me logo Genes that share pathways with NOCT: view

Pathways by source for NOCT Gene

1 BioSystems pathway for NOCT Gene
1 Qiagen pathway for NOCT Gene
  • Cell Cycle Control by BTG Proteins

Gene Ontology (GO) - Biological Process for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0006366 transcription by RNA polymerase II TAS 10521507
GO:0006739 NADP metabolic process IDA 31147539
GO:0007623 circadian rhythm TAS --
GO:0009991 response to extracellular stimulus IEA,ISS --
genes like me logo Genes that share ontologies with NOCT: view

No data available for SIGNOR curated interactions for NOCT Gene

Drugs & Compounds for NOCT Gene

No Compound Related Data Available

Transcripts for NOCT Gene

mRNA/cDNA for NOCT Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOCT

Alternative Splicing Database (ASD) splice patterns (SP) for NOCT Gene

No ASD Table

Relevant External Links for NOCT Gene

GeneLoc Exon Structure for
NOCT

Expression for NOCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOCT

mRNA Expression by UniProt/SwissProt for NOCT Gene:

Q9UK39-NOCT_HUMAN
Tissue specificity: Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.

Evidence on tissue expression from TISSUES for NOCT Gene

  • Muscle(4.1)
  • Liver(2.9)
  • Nervous system(2.5)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with NOCT: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOCT Gene

Orthologs for NOCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOCT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCRN4L 30 31
  • 99.45 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCRN4L 30 31
  • 89.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccrn4l 30
  • 85.87 (n)
Cow
(Bos Taurus)
Mammalia CCRN4L 30 31
  • 85.76 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccrn4l 30 31
  • 85.3 (n)
OneToOne
Noct 17
Oppossum
(Monodelphis domestica)
Mammalia CCRN4L 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCRN4L 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MNOC 31
  • 84 (a)
OneToOne
CCRN4L 30
  • 76.09 (n)
Lizard
(Anolis carolinensis)
Reptilia CCRN4L 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ccrn4l 30
  • 73.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia ccrn4l-A 30
Zebrafish
(Danio rerio)
Actinopterygii CCRN4L (2 of 2) 31
  • 65 (a)
OneToMany
ccrn4la 31
  • 56 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13994 30
Fruit Fly
(Drosophila melanogaster)
Insecta cu 30 31
  • 53.87 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009893 30
  • 51.99 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 31
  • 13 (a)
OneToMany
Species where no ortholog for NOCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NOCT Gene

ENSEMBL:
Gene Tree for NOCT (if available)
TreeFam:
Gene Tree for NOCT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOCT: view image

Paralogs for NOCT Gene

Paralogs for NOCT Gene

Pseudogenes.org Pseudogenes for NOCT Gene

genes like me logo Genes that share paralogs with NOCT: view

Variants for NOCT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOCT Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
738931 Likely Benign: not provided 139,044,907(+) C/T SYNONYMOUS_VARIANT
770156 Benign: not provided 139,043,288(+) T/C SYNONYMOUS_VARIANT
rs2271777 - p.His140Tyr

Additional dbSNP identifiers (rs#s) for NOCT Gene

Structural Variations from Database of Genomic Variants (DGV) for NOCT Gene

Variant ID Type Subtype PubMed ID
esv1464767 CNV deletion 17803354
esv2040934 CNV deletion 18987734
esv2544225 CNV deletion 19546169
esv2728425 CNV deletion 23290073
esv3564713 CNV deletion 23714750
esv3602431 CNV loss 21293372
nsv1073374 CNV deletion 25765185
nsv1126043 CNV deletion 24896259
nsv1151552 CNV deletion 26484159
nsv956378 CNV deletion 24416366

Variation tolerance for NOCT Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOCT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOCT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOCT Gene

Disorders for NOCT Gene

No disorders were found for NOCT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOCT Gene

Publications for NOCT Gene

  1. Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion. (PMID: 10521507) Dupressoir A … Heidmann T (The Journal of biological chemistry 1999) 2 3 4 23
  2. Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. (PMID: 11394964) Wang Y … Besharse JC (BMC developmental biology 2001) 2 3 23
  3. The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled). (PMID: 31147539) Estrella MA … Korennykh A (Nature communications 2019) 3 4
  4. Crystal Structure of Human Nocturnin Catalytic Domain. (PMID: 30389976) Estrella MA … Korennykh A (Scientific reports 2018) 3 4
  5. The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells. (PMID: 29860338) Abshire ET … Trievel RC (Nucleic acids research 2018) 3 4

Products for NOCT Gene

  • Signalway ELISA kits for NOCT

Sources for NOCT Gene