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Aliases for NOC4L Gene

Aliases for NOC4L Gene

  • Nucleolar Complex Associated 4 Homolog 2 3 5
  • Nucleolar Complex-Associated Protein 4-Like Protein 3 4
  • NOC4 Protein Homolog 3 4
  • NOC4-Like Protein 3 4
  • Nucleolar Complex Associated 4 Homolog (S. Cerevisiae) 2
  • Nucleolar Complex Protein 4 Homolog 3
  • NET49 3
  • UTP19 3
  • NOC4 3

External Ids for NOC4L Gene

Previous GeneCards Identifiers for NOC4L Gene

  • GC12P131296
  • GC12P131194
  • GC12P132628
  • GC12P129514

Summaries for NOC4L Gene

GeneCards Summary for NOC4L Gene

NOC4L (Nucleolar Complex Associated 4 Homolog) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for NOC4L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOC4L Gene

Genomics for NOC4L Gene

GeneHancer (GH) Regulatory Elements for NOC4L Gene

Promoters and enhancers for NOC4L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J132142 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661.6 -0.1 -76 2.7 CLOCK SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 DDX51 NOC4L EP400 SFSWAP ZNF140 ZNF891 EP400P1 GALNT9 GOLGA3 ZNF605
GH12J132827 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 46 +684.1 684061 2.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GOLGA3 ANKLE2 ZNF140 ZNF26 EP400 NOC4L CHFR ZNF891 POLE ZNF268
GH12J131927 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 48.2 -215.2 -215199 3.3 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 PUS1 ENSG00000255992 EP400 GOLGA3 EP400P1 NOC4L ANKLE2 SFSWAP DDX51 POLE
GH12J132597 Enhancer 1.2 Ensembl ENCODE 74.4 +453.9 453892 1.8 HDGF ARNT YBX1 ZNF2 YY1 ZNF143 ZNF548 SP3 ZNF662 REST ZNF140 EP400 ZNF84 ZNF268 ZNF891 ZNF26 GOLGA3 ZNF605 ANKLE2 DDX51
GH12J132686 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 40.5 +543.7 543704 3.9 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 E2F8 ZNF207 ZNF143 POLE ENSG00000256632 PXMP2 NOC4L EP400 ANKLE2 ZNF891 DDX51 ZNF140 SFSWAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOC4L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOC4L gene promoter:
  • Pax-4a
  • GATA-1
  • Ik-2
  • YY1
  • HEN1
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • Brachyury
  • AML1a

Genomic Locations for NOC4L Gene

Genomic Locations for NOC4L Gene
8,052 bases
Plus strand
8,021 bases
Plus strand

Genomic View for NOC4L Gene

Genes around NOC4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOC4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOC4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOC4L Gene

Proteins for NOC4L Gene

  • Protein details for NOC4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar complex protein 4 homolog
    Protein Accession:
    Secondary Accessions:
    • Q8N2S5
    • Q96I14

    Protein attributes for NOC4L Gene

    516 amino acids
    Molecular mass:
    58468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOC4L Gene

Post-translational modifications for NOC4L Gene

  • Ubiquitination at Lys138
  • Modification sites at PhosphoSitePlus

Other Protein References for NOC4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOC4L Gene

Domains & Families for NOC4L Gene

Gene Families for NOC4L Gene

Protein Domains for NOC4L Gene

Suggested Antigen Peptide Sequences for NOC4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CBF/MAK21 family.
  • Belongs to the CBF/MAK21 family.
genes like me logo Genes that share domains with NOC4L: view

Function for NOC4L Gene

Phenotypes From GWAS Catalog for NOC4L Gene

Gene Ontology (GO) - Molecular Function for NOC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003723 RNA binding HDA 22658674
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NOC4L: view
genes like me logo Genes that share phenotypes with NOC4L: view

Animal Model Products

CRISPR Products

miRNA for NOC4L Gene

miRTarBase miRNAs that target NOC4L

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOC4L

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOC4L Gene

Localization for NOC4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOC4L Gene

Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOC4L gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus ISS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NOC4L: view

Pathways & Interactions for NOC4L Gene

genes like me logo Genes that share pathways with NOC4L: view

Gene Ontology (GO) - Biological Process for NOC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with NOC4L: view

No data available for SIGNOR curated interactions for NOC4L Gene

Drugs & Compounds for NOC4L Gene

No Compound Related Data Available

Transcripts for NOC4L Gene

mRNA/cDNA for NOC4L Gene

Unigene Clusters for NOC4L Gene

Nucleolar complex associated 4 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOC4L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOC4L Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - -
SP2: -

Relevant External Links for NOC4L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOC4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOC4L Gene

Protein differential expression in normal tissues from HIPED for NOC4L Gene

This gene is overexpressed in Bone (29.3) and Peripheral blood mononuclear cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOC4L Gene

Protein tissue co-expression partners for NOC4L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOC4L Gene:


SOURCE GeneReport for Unigene cluster for NOC4L Gene:


Evidence on tissue expression from TISSUES for NOC4L Gene

  • Nervous system(4.6)
  • Eye(4)
genes like me logo Genes that share expression patterns with NOC4L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOC4L Gene

Orthologs for NOC4L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOC4L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOC4L 33
  • 98.65 (n)
(Bos Taurus)
Mammalia NOC4L 34 33
  • 84.13 (n)
(Canis familiaris)
Mammalia NOC4L 34 33
  • 82.04 (n)
(Mus musculus)
Mammalia Noc4l 16 34 33
  • 79.84 (n)
(Rattus norvegicus)
Mammalia Noc4l 33
  • 79.52 (n)
(Monodelphis domestica)
Mammalia NOC4L 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
-- 34
  • 50 (a)
(Gallus gallus)
Aves EP400 33
  • 63.76 (n)
NOC4L 34
  • 58 (a)
(Anolis carolinensis)
Reptilia NOC4L 34
  • 54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33955 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3697 33
(Danio rerio)
Actinopterygii noc4l 34 33
  • 57.96 (n)
sbcb534 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.381 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001872 33
  • 47.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2875 34 33
  • 46.45 (n)
(Caenorhabditis elegans)
Secernentea T20B12.3 34
  • 24 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10890g 33
  • 49.38 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR171C 33
  • 48.38 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOC4 36 34 33
  • 43.82 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2762 33
  • 44.16 (n)
(Oryza sativa)
Liliopsida Os04g0585300 33
  • 45.91 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00501 33
  • 47.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1604.06c 33
  • 41.57 (n)
Species where no ortholog for NOC4L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOC4L Gene

Gene Tree for NOC4L (if available)
Gene Tree for NOC4L (if available)
Evolutionary constrained regions (ECRs) for NOC4L: view image

Paralogs for NOC4L Gene

No data available for Paralogs for NOC4L Gene

Variants for NOC4L Gene

Sequence variations from dbSNP and Humsavar for NOC4L Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000269617 -- 132,142,812(+) G/A/C upstream_transcript_variant
rs1000492604 -- 132,151,290(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000521431 -- 132,143,414(+) C/G upstream_transcript_variant
rs1000819124 -- 132,143,415(+) G/A upstream_transcript_variant
rs1000977919 -- 132,147,451(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOC4L Gene

Variant ID Type Subtype PubMed ID
nsv952511 CNV deletion 24416366
nsv944 CNV insertion 18451855
nsv826563 CNV gain 20364138
nsv560935 CNV loss 21841781
nsv53069 CNV deletion 16902084
nsv509493 CNV insertion 20534489
nsv470333 CNV loss 18288195
nsv428285 CNV gain 18775914
nsv1143581 CNV deletion 24896259
nsv1041402 CNV gain 25217958
esv992467 CNV loss 20482838
esv990728 CNV deletion 20482838
esv29137 CNV gain+loss 19812545
esv2746916 CNV deletion 23290073
esv2746915 CNV deletion 23290073
esv2670820 CNV deletion 23128226
dgv945e59 CNV duplication 20981092
dgv3018n54 CNV loss 21841781
dgv3017n54 CNV loss 21841781
dgv3016n54 CNV loss 21841781
dgv3015n54 CNV loss 21841781
dgv3014n54 CNV loss 21841781
dgv103n21 CNV loss 19592680

Variation tolerance for NOC4L Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOC4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOC4L Gene

Disorders for NOC4L Gene

Additional Disease Information for NOC4L

No disorders were found for NOC4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOC4L Gene

Publications for NOC4L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. (PMID: 12446671) Milkereit P … Tschochner H (The Journal of biological chemistry 2003) 2 3 58
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for NOC4L Gene

Sources for NOC4L Gene

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