Aliases for NOC3L Gene
Aliases for NOC3L Gene
External Ids for NOC3L Gene
- HGNC: 24034
- Entrez Gene: 64318
- Ensembl: ENSG00000173145
- OMIM: 610769
- UniProtKB: Q8WTT2
Previous HGNC Symbols for NOC3L Gene
- C10orf117
Previous GeneCards Identifiers for NOC3L Gene
- GC10M096083
- GC10M089719
Summaries for NOC3L Gene
GeneCards Summary for NOC3L Gene
NOC3L (NOC3 Like DNA Replication Regulator) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot for NOC3L Gene
-
May be required for adipogenesis.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOC3L Gene
Genomics for NOC3L Gene
GeneHancer (GH) Regulatory Elements for NOC3L Gene
Promoters and enhancers for NOC3L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NOC3L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NOC3L gene promoter:
-
- PPAR-gamma2
- PPAR-gamma1
- C/EBPalpha
- c-Ets-1
- FOXD3
- FOXO1
- FOXO1a
- C/EBPbeta
- Evi-1
Regulatory Element Products
Genomic Locations for NOC3L Gene
Genomic Locations for NOC3L Gene
- chr10:94,314,907-94,362,976
- (GRCh38/hg38)
- Size:
- 48,070 bases
- Orientation:
- Minus strand
- chr10:96,075,004-96,122,716
- (GRCh37/hg19)
- Size:
- 47,713 bases
- Orientation:
- Minus strand
Genomic View for NOC3L Gene
Genes around NOC3L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.33 by Entrez Gene
- 10q23.33 by HGNC
- 10q23.33 by Ensembl
NOC3L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NOC3L Gene
Proteins for NOC3L Gene
-
Protein details for NOC3L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WTT2-NOC3L_HUMAN
- Recommended name:
- Nucleolar complex protein 3 homolog
- Protein Accession:
- Q8WTT2
- Q9H5M6
- Q9H9D8
Protein attributes for NOC3L Gene
- Size:
- 800 amino acids
- Molecular mass:
- 92548 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB14291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15599.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for NOC3L Gene
Post-translational modifications for NOC3L Gene
Other Protein References for NOC3L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NOC3L
- Novus Biologicals Antibodies for NOC3L
- Invitrogen Antibodies for NOC3L
- GeneTex NOC3L Antibody for NOC3L
-
Boster Bio Antibodies for NOC3L
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NOC3L
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- Novus Biologicals proteins for NOC3L
- antibodies-online: Search results for 3 available NOC3L Proteins ranked by validation data
- Compare Top NOC3L Proteins
-
Quality Products:
- Search GeneTex for Proteins for NOC3L
Assay Products
No data available for DME Specific Peptides for NOC3L Gene
Domains & Families for NOC3L Gene
Gene Families for NOC3L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NOC3L Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NOC3L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WTT2- Family:
-
- Belongs to the CBF/MAK21 family.
Function for NOC3L Gene
Molecular function for NOC3L Gene
- UniProtKB/Swiss-Prot Function:
- May be required for adipogenesis.
Phenotypes From GWAS Catalog for NOC3L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISM | 19274049 |
| GO:0003682 | chromatin binding | IBA | -- |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005488 | binding | IEA | -- |
Phenotypes for NOC3L Gene
- MGI mutant phenotypes for NOC3L:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NOC3L:
Animal Models for NOC3L Gene
- MGI Knock Outs for NOC3L:
-
- Noc3l Noc3l<tm1Maim>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NOC3L
-
CRISPR Products
-
OriGene CRISPR knockouts for NOC3L
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- genomics-online: gRNA clones - Search results for available NOC3L gene related products
- Applied Biological Materials CRISPR for NOC3L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NOC3L
- GenScript: Design CRISPR guide RNA sequences for NOC3L
miRNA for NOC3L Gene
- miRTarBase miRNAs that target NOC3L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NOC3L
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- genomics-online: shRNA clones - Search results for available NOC3L gene related products
Clone Products
- Sino Biological Human cDNA Clone for NOC3L
- VectorBuilder custom plasmid, inducible vectors for NOC3L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOC3L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NOC3L
- genomics-online: cdna clones - Search results for available NOC3L gene related products
- orf clones - Search results for available NOC3L gene related products
- Applied Biological Materials Clones for NOC3L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOC3L Gene
Localization for NOC3L Gene
Subcellular locations from UniProtKB/Swiss-Prot for NOC3L Gene
- Nucleus, nucleolus. Nucleus speckle.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 1 |
- Nucleoli (4)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IBA | -- |
| GO:0005730 | nucleolus | IEA,IDA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0016607 | nuclear speck | IEA | -- |
Pathways & Interactions for NOC3L Gene
No Data Available
Interacting Proteins for NOC3L Gene
GPS-Prot Interaction Network for NOC3L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0045444 | fat cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NOC3L Gene
Transcripts for NOC3L Gene
mRNA/cDNA for NOC3L Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (106) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000371361 3455 bps (uc001kjq.2)
- ENST00000461562 576 bps (uc057uzb.1)
- ENST00000463649 2190 bps (uc057uza.1)
Unigene Clusters for NOC3L Gene
CRISPR Products
-
OriGene CRISPR knockouts for NOC3L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NOC3L
- genomics-online: gRNA clones - Search results for available NOC3L gene related products
- Applied Biological Materials CRISPR for NOC3L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NOC3L
- GenScript: Design CRISPR guide RNA sequences for NOC3L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NOC3L
- Browse OriGene Inhibitory RNA Products For NOC3L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOC3L
- genomics-online: shRNA clones - Search results for available NOC3L gene related products
Clone Products
- Sino Biological Human cDNA Clone for NOC3L
- VectorBuilder custom plasmid, inducible vectors for NOC3L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOC3L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NOC3L
- genomics-online: cdna clones - Search results for available NOC3L gene related products
- orf clones - Search results for available NOC3L gene related products
- Applied Biological Materials Clones for NOC3L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
| ExUns: | 23 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: |
Expression for NOC3L Gene
This gene is overexpressed in Heart (32.9), CD8 Tcells (6.6), and Colon muscle (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOC3L Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NOC3L Gene:
NOC3LSOURCE GeneReport for Unigene cluster for NOC3L Gene:
Hs.74899mRNA Expression by UniProt/SwissProt for NOC3L Gene:
Q8WTT2-NOC3L_HUMAN
Tissue specificity:
Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.
Primer Products
-
OriGene qPCR primer pairs and template standards for NOC3L
-
OriGene qPCR primer pairs for NOC3L
- genomics-online: primer clones - Search results for available NOC3L gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOC3L Gene
Orthologs for NOC3L Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NOC3L 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NOC3L 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NOC3L 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Noc3l 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Noc3l 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NOC3L 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | NOC3L 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NOC3L 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | noc3l 33 |
|
||
| Str.1945 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16127 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | noc3l 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG1234 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010308 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C37H5.5 34 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NOC3 36 34 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D09735g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACR032C 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G79150 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0498500 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | noc3 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00337 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2414 34 |
|
OneToOne |
- Species where no ortholog for NOC3L was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NOC3L Gene
- ENSEMBL:
- Gene Tree for NOC3L (if available)
- TreeFam:
- Gene Tree for NOC3L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NOC3L: view image
Paralogs for NOC3L Gene
No data available for Paralogs for NOC3L Gene
Variants for NOC3L Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000120410 | -- | 94,342,130(-) | G/A | intron_variant | |
| rs1000142307 | -- | 94,360,134(-) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000145930 | -- | 94,362,276(-) | T/ | genic_upstream_transcript_variant, intron_variant | |
| rs1000390665 | -- | 94,355,970(-) | T/C | intron_variant | |
| rs1000474000 | -- | 94,360,538(-) | G/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv831946 | CNV | loss | 17160897 |
| esv3407687 | CNV | insertion | 20981092 |
| esv3307857 | CNV | mobile element insertion | 20981092 |
| esv2761616 | CNV | gain | 21179565 |
| esv2480129 | CNV | deletion | 19546169 |
Residual Variation Intolerance Score:
66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.69;
96.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NOC3L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NOC3L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOC3L Gene
Disorders for NOC3L Gene
Additional Disease Information for NOC3L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NOC3L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOC3L Gene
Publications for NOC3L Gene
- Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. (PMID: 15564382) Tominaga K … Imagawa M (Journal of cell science 2004) 2 3 4 58
- FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation. (PMID: 18520036) Johmura Y … Imagawa M (Biological & pharmaceutical bulletin 2008) 2 3 58
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
Products for NOC3L Gene
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- VectorBuilder custom plasmid, inducible vectors for NOC3L
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available NOC3L Antibodies ranked by validation data
- Compare Top NOC3L Antibodies
- antibodies-online: Search results for available NOC3L related products ranked by validation data
- antibodies-online: Search results for 3 available NOC3L Proteins ranked by validation data
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- Quality Products:
- GeneTex NOC3L Antibody for NOC3L
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- genomics-online: cdna clones - Search results for available NOC3L gene related products
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- genomics-online: gRNA clones - Search results for available NOC3L gene related products
- genomics-online: primer clones - Search results for available NOC3L gene related products
- genomics-online: shRNA clones - Search results for available NOC3L gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NOC3L
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- Boster Bio Antibodies for NOC3L
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Sources for NOC3L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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