Aliases for NOC3L Gene

Aliases for NOC3L Gene

  • NOC3 Like DNA Replication Regulator 2 3 5
  • Factor For Adipocyte Differentiation 24 2 3 4
  • Nucleolar Complex-Associated Protein 3-Like Protein 3 4
  • Nucleolar Complex Protein 3 Homolog 3 4
  • NOC3 Protein Homolog 3 4
  • C10orf117 3 4
  • FAD24 3 4
  • AD24 3 4
  • Nucleolar Complex Associated 3 Homolog (S. Cerevisiae) 2
  • Nucleolar Complex Associated 3 Homolog 3
  • Chromosome 10 Open Reading Frame 117 2
  • NOC3-Like DNA Replication Regulator 2
  • NOC3L DNA Replication Regulator 3
  • NOC3-Like Protein 4

External Ids for NOC3L Gene

Previous HGNC Symbols for NOC3L Gene

  • C10orf117

Previous GeneCards Identifiers for NOC3L Gene

  • GC10M096083
  • GC10M089719

Summaries for NOC3L Gene

GeneCards Summary for NOC3L Gene

NOC3L (NOC3 Like DNA Replication Regulator) is a Protein Coding gene. Diseases associated with NOC3L include Nephrotic Syndrome, Type 3. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot Summary for NOC3L Gene

Additional gene information for NOC3L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOC3L Gene

Genomics for NOC3L Gene

GeneHancer (GH) Regulatory Elements for NOC3L Gene

Promoters and enhancers for NOC3L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOC3L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOC3L gene promoter:
  • c-Ets-1
  • C/EBPalpha
  • C/EBPbeta
  • Evi-1
  • FOXD3
  • FOXO1
  • FOXO1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for NOC3L Gene

Genomic Locations for NOC3L Gene
chr10:94,314,907-94,362,976
(GRCh38/hg38)
Size:
48,070 bases
Orientation:
Minus strand
chr10:96,075,004-96,122,716
(GRCh37/hg19)
Size:
47,713 bases
Orientation:
Minus strand

Genomic View for NOC3L Gene

Genes around NOC3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOC3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOC3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOC3L Gene

Proteins for NOC3L Gene

  • Protein details for NOC3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTT2-NOC3L_HUMAN
    Recommended name:
    Nucleolar complex protein 3 homolog
    Protein Accession:
    Q8WTT2
    Secondary Accessions:
    • Q9H5M6
    • Q9H9D8

    Protein attributes for NOC3L Gene

    Size:
    800 amino acids
    Molecular mass:
    92548 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15599.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NOC3L Gene

Post-translational modifications for NOC3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOC3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOC3L Gene

Domains & Families for NOC3L Gene

Gene Families for NOC3L Gene

Protein Domains for NOC3L Gene

Suggested Antigen Peptide Sequences for NOC3L Gene

GenScript: Design optimal peptide antigens:
  • Nucleolar complex-associated protein 3-like protein (NOC3L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WTT2

UniProtKB/Swiss-Prot:

NOC3L_HUMAN :
  • Belongs to the CBF/MAK21 family.
Family:
  • Belongs to the CBF/MAK21 family.
genes like me logo Genes that share domains with NOC3L: view

Function for NOC3L Gene

Molecular function for NOC3L Gene

UniProtKB/Swiss-Prot Function:
May be required for adipogenesis.

Phenotypes From GWAS Catalog for NOC3L Gene

Gene Ontology (GO) - Molecular Function for NOC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NOC3L: view
genes like me logo Genes that share phenotypes with NOC3L: view

Animal Models for NOC3L Gene

MGI Knock Outs for NOC3L:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOC3L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOC3L Gene

Localization for NOC3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOC3L Gene

Nucleus, nucleolus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOC3L gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA --
GO:0005730 nucleolus IEA,IDA --
GO:0005739 mitochondrion IDA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with NOC3L: view

Pathways & Interactions for NOC3L Gene

PathCards logo

SuperPathways for NOC3L Gene

No Data Available

SIGNOR curated interactions for NOC3L Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NOC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045444 fat cell differentiation IEA --
genes like me logo Genes that share ontologies with NOC3L: view

No data available for Pathways by source for NOC3L Gene

Drugs & Compounds for NOC3L Gene

No Compound Related Data Available

Transcripts for NOC3L Gene

mRNA/cDNA for NOC3L Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(106) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOC3L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOC3L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1:
SP2: - -
SP3: -
SP4:

ExUns: 23
SP1:
SP2:
SP3:
SP4:

Relevant External Links for NOC3L Gene

GeneLoc Exon Structure for
NOC3L
ECgene alternative splicing isoforms for
NOC3L

Expression for NOC3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOC3L Gene

Protein differential expression in normal tissues from HIPED for NOC3L Gene

This gene is overexpressed in Heart (32.9), CD8 Tcells (6.6), and Colon muscle (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOC3L Gene



Protein tissue co-expression partners for NOC3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOC3L Gene:

NOC3L

SOURCE GeneReport for Unigene cluster for NOC3L Gene:

Hs.74899

mRNA Expression by UniProt/SwissProt for NOC3L Gene:

Q8WTT2-NOC3L_HUMAN
Tissue specificity: Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.
genes like me logo Genes that share expression patterns with NOC3L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOC3L Gene

Orthologs for NOC3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOC3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOC3L 33 32
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NOC3L 33 32
  • 91.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NOC3L 33 32
  • 90.14 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noc3l 32
  • 85.95 (n)
mouse
(Mus musculus)
Mammalia Noc3l 17 33 32
  • 85.36 (n)
oppossum
(Monodelphis domestica)
Mammalia NOC3L 33
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 80 (a)
OneToMany
-- 33
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves NOC3L 33 32
  • 75.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOC3L 33
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noc3l 32
  • 68.99 (n)
Str.1945 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.16127 32
zebrafish
(Danio rerio)
Actinopterygii noc3l 33 32
  • 65.23 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1234 33 32
  • 48.5 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010308 32
  • 48.19 (n)
worm
(Caenorhabditis elegans)
Secernentea C37H5.5 33 32
  • 47.08 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOC3 35 33 32
  • 46.68 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09735g 32
  • 46.15 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR032C 32
  • 44.37 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79150 32
  • 45.33 (n)
rice
(Oryza sativa)
Liliopsida Os06g0498500 32
  • 46.57 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes noc3 32
  • 46.21 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00337 32
  • 44.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2414 33
  • 39 (a)
OneToOne
Species where no ortholog for NOC3L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOC3L Gene

ENSEMBL:
Gene Tree for NOC3L (if available)
TreeFam:
Gene Tree for NOC3L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOC3L: view image

Paralogs for NOC3L Gene

No data available for Paralogs for NOC3L Gene

Variants for NOC3L Gene

Sequence variations from dbSNP and Humsavar for NOC3L Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs11187870 likely-benign, Nephrotic syndrome 94,328,109(-) G/C genic_downstream_transcript_variant, intron_variant
rs146319051 uncertain-significance, Nephrotic syndrome 94,328,211(-) T/C genic_downstream_transcript_variant, intron_variant
rs184484950 uncertain-significance, Nephrotic syndrome 94,328,163(-) T/G genic_downstream_transcript_variant, intron_variant
rs267606953 pathogenic, Nephrotic syndrome, type 3 94,322,006(-) C/T genic_downstream_transcript_variant, intron_variant
rs3203713 likely-benign, Nephrotic syndrome 94,327,971(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOC3L Gene

Variant ID Type Subtype PubMed ID
esv2480129 CNV deletion 19546169
esv2761616 CNV gain 21179565
esv3307857 CNV mobile element insertion 20981092
esv3407687 CNV insertion 20981092
nsv831946 CNV loss 17160897

Variation tolerance for NOC3L Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.69; 96.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOC3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOC3L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOC3L Gene

Disorders for NOC3L Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOC3L Gene - From: GeneCards

Disorder Aliases PubMed IDs
nephrotic syndrome, type 3
  • nphs3
- elite association - COSMIC cancer census association via MalaCards
Search NOC3L in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOC3L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NOC3L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOC3L Gene

Publications for NOC3L Gene

  1. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. (PMID: 15564382) Tominaga K … Imagawa M (Journal of cell science 2004) 2 3 4 56
  2. FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation. (PMID: 18520036) Johmura Y … Imagawa M (Biological & pharmaceutical bulletin 2008) 2 3 56
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 43 56
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for NOC3L Gene

Sources for NOC3L Gene