Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008] See more...

Aliases for NOC2L Gene

Aliases for NOC2L Gene

  • NOC2 Like Nucleolar Associated Transcriptional Repressor 2 3 5
  • Novel INHAT Repressor 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 12 2 3
  • Nucleolar Complex Protein 2 Homolog 3 4
  • Protein NOC2 Homolog 3 4
  • NOC2-Like Protein 3 4
  • NIR 3 4
  • Novel INHAT (Inhibitor Of Histone Acetyltransferase) Repressor 3
  • Nucleolar Complex Associated 2 Homolog (S. Cerevisiae) 2
  • NOC2L Nucleolar Associated Transcriptional Repressor 3
  • Nucleolar Complex Associated 2 Homolog 3
  • PPP1R112 3
  • NET15 3
  • NET7 3

External Ids for NOC2L Gene

Previous GeneCards Identifiers for NOC2L Gene

  • GC01M000920
  • GC01M000869
  • GC01M000879
  • GC01M000151
  • GC01M000945

Summaries for NOC2L Gene

Entrez Gene Summary for NOC2L Gene

  • Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NOC2L Gene

NOC2L (NOC2 Like Nucleolar Associated Transcriptional Repressor) is a Protein Coding gene. Diseases associated with NOC2L include Epiphyseal Chondrodysplasia, Miura Type and Retinitis Pigmentosa, Y-Linked. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot Summary for NOC2L Gene

  • Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.

Gene Wiki entry for NOC2L Gene

Additional gene information for NOC2L Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOC2L Gene

Genomics for NOC2L Gene

GeneHancer (GH) Regulatory Elements for NOC2L Gene

Promoters and enhancers for NOC2L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOC2L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOC2L

Top Transcription factor binding sites by QIAGEN in the NOC2L gene promoter:
  • c-Myc
  • CREB
  • deltaCREB
  • Max
  • Max1
  • XBP-1
  • YY1

Genomic Locations for NOC2L Gene

Genomic Locations for NOC2L Gene
chr1:944,203-959,309
(GRCh38/hg38)
Size:
15,107 bases
Orientation:
Minus strand
chr1:879,583-894,689
(GRCh37/hg19)
Size:
15,107 bases
Orientation:
Minus strand

Genomic View for NOC2L Gene

Genes around NOC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOC2L Gene

Proteins for NOC2L Gene

  • Protein details for NOC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3T9-NOC2L_HUMAN
    Recommended name:
    Nucleolar complex protein 2 homolog
    Protein Accession:
    Q9Y3T9
    Secondary Accessions:
    • Q5SVA3
    • Q9BTN6

    Protein attributes for NOC2L Gene

    Size:
    749 amino acids
    Molecular mass:
    84919 Da
    Quaternary structure:
    • Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes.

neXtProt entry for NOC2L Gene

Post-translational modifications for NOC2L Gene

  • Ubiquitination at Lys168, Lys516, Lys606, and Lys637
  • Modification sites at PhosphoSitePlus

Other Protein References for NOC2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOC2L Gene

Domains & Families for NOC2L Gene

Gene Families for NOC2L Gene

Protein Domains for NOC2L Gene

Blocks:
  • Protein of unknown function UPF0120
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOC2L Gene

GenScript: Design optimal peptide antigens:
  • NOC2-like protein (NOC2L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3T9

UniProtKB/Swiss-Prot:

NOC2L_HUMAN :
  • Belongs to the NOC2 family.
Family:
  • Belongs to the NOC2 family.
genes like me logo Genes that share domains with NOC2L: view

Function for NOC2L Gene

Molecular function for NOC2L Gene

UniProtKB/Swiss-Prot Function:
Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4 and CD40L in B-cells.

Phenotypes From GWAS Catalog for NOC2L Gene

Gene Ontology (GO) - Molecular Function for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 16322561
GO:0003714 transcription corepressor activity IDA 16322561
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 16322561
GO:0031491 nucleosome binding IDA 16322561
genes like me logo Genes that share ontologies with NOC2L: view
genes like me logo Genes that share phenotypes with NOC2L: view

Animal Models for NOC2L Gene

MGI Knock Outs for NOC2L:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOC2L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOC2L Gene

Localization for NOC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOC2L Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOC2L gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
mitochondrion 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16322561
GO:0005654 nucleoplasm IBA,TAS --
GO:0005730 nucleolus IDA,IBA 20123734
GO:0005829 cytosol IDA --
GO:0030690 Noc1p-Noc2p complex IBA 21873635
genes like me logo Genes that share ontologies with NOC2L: view

Pathways & Interactions for NOC2L Gene

genes like me logo Genes that share pathways with NOC2L: view

Gene Ontology (GO) - Biological Process for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 20123734
GO:0002903 negative regulation of B cell apoptotic process IMP 20959462
GO:0006915 apoptotic process IEA --
GO:0031497 chromatin assembly IDA 16322561
GO:0034644 cellular response to UV IDA 20959462
genes like me logo Genes that share ontologies with NOC2L: view

No data available for SIGNOR curated interactions for NOC2L Gene

Drugs & Compounds for NOC2L Gene

(6) Drugs for NOC2L Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pidolic acid Approved, Investigational Pharma Target 0
2-(N-Morpholino)-Ethanesulfonic Acid Experimental Pharma Target 0
Pentaglyme Experimental Pharma Target 0

(3) Additional Compounds for NOC2L Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NOC2L: view

Transcripts for NOC2L Gene

mRNA/cDNA for NOC2L Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOC2L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOC2L Gene

No ASD Table

Relevant External Links for NOC2L Gene

GeneLoc Exon Structure for
NOC2L

Expression for NOC2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOC2L Gene

Protein differential expression in normal tissues from HIPED for NOC2L Gene

This gene is overexpressed in Liver (20.5) and Blymphocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOC2L Gene



Protein tissue co-expression partners for NOC2L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOC2L

SOURCE GeneReport for Unigene cluster for NOC2L Gene:

Hs.405987

Evidence on tissue expression from TISSUES for NOC2L Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Skin(3.3)
  • Intestine(2.8)
  • Lung(2.4)
  • Blood(2)
genes like me logo Genes that share expression patterns with NOC2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOC2L Gene

Orthologs for NOC2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOC2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOC2L 31
  • 99 (a)
OneToOne
LOC100608665 30
  • 98.34 (n)
cow
(Bos Taurus)
Mammalia NOC2L 31 30
  • 82.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NOC2L 31 30
  • 81.2 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noc2l 30
  • 78.98 (n)
mouse
(Mus musculus)
Mammalia Noc2l 17 31 30
  • 77.39 (n)
oppossum
(Monodelphis domestica)
Mammalia NOC2L 31
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOC2L 31
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOC2L 31 30
  • 67.03 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOC2L 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noc2l 30
  • 62.13 (n)
Str.1780 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5905 30
zebrafish
(Danio rerio)
Actinopterygii noc2l 31 30
  • 61.17 (n)
OneToOne
idibd5110 30
fruit fly
(Drosophila melanogaster)
Insecta CG9246 31 30
  • 50.55 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010536 30
  • 49.29 (n)
worm
(Caenorhabditis elegans)
Secernentea pro-2 31 30
  • 39.75 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL277W 30
  • 46.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01122g 30
  • 42.35 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOC2 33 31 30
  • 41.46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18220 30
  • 43.44 (n)
rice
(Oryza sativa)
Liliopsida Os10g0495500 30
  • 44.31 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02066 30
  • 47.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.04 30
  • 41.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1430 31
  • 33 (a)
OneToOne
Species where no ortholog for NOC2L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOC2L Gene

ENSEMBL:
Gene Tree for NOC2L (if available)
TreeFam:
Gene Tree for NOC2L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOC2L: view image

Paralogs for NOC2L Gene

Pseudogenes.org Pseudogenes for NOC2L Gene

genes like me logo Genes that share paralogs with NOC2L: view

No data available for Paralogs for NOC2L Gene

Variants for NOC2L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOC2L Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
730521 Benign: not provided 945,564(-) G/A SYNONYMOUS_VARIANT
730522 Benign: not provided 952,609(-) A/G INTRON_VARIANT
734103 Benign: not provided 954,070(-) C/A SYNONYMOUS_VARIANT
735490 Benign: not provided 952,029(-) G/C SYNONYMOUS_VARIANT
735491 Likely Benign: not provided 956,013(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for NOC2L Gene

Structural Variations from Database of Genomic Variants (DGV) for NOC2L Gene

Variant ID Type Subtype PubMed ID
dgv13e59 CNV duplication 20981092
dgv2n67 CNV gain 20364138
dgv5n100 CNV gain 25217958
dgv9n54 CNV loss 21841781
esv2762302 CNV gain 21179565
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv428334 CNV gain 18775914
nsv482937 CNV loss 15286789
nsv509035 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544895 CNV loss 21841781
nsv832980 CNV gain 17160897
nsv950451 CNV deletion 24416366

Variation tolerance for NOC2L Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOC2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOC2L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOC2L Gene

Disorders for NOC2L Gene

MalaCards: The human disease database

(3) MalaCards diseases for NOC2L Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NOC2L in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOC2L

genes like me logo Genes that share disorders with NOC2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOC2L Gene

Publications for NOC2L Gene

  1. NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. (PMID: 20123734) Heyne K … Roemer K (Nucleic acids research 2010) 2 3 4 54
  2. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. (PMID: 16322561) Hublitz P … Schüle R (Genes & development 2005) 3 4 23 54
  3. Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits. (PMID: 22363708) Wu J … Ke Y (PloS one 2012) 2 3 54
  4. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. (PMID: 20959462) Wu L … Jain A (The Journal of biological chemistry 2011) 3 4 54
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54

Products for NOC2L Gene

Sources for NOC2L Gene