Aliases for NOC2L Gene
External Ids for NOC2L Gene
Previous GeneCards Identifiers for NOC2L Gene
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NOC2L Gene
NOC2L (NOC2 Like Nucleolar Associated Transcriptional Repressor) is a Protein Coding gene. Diseases associated with NOC2L include Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive and Griscelli Syndrome, Type 2. Among its related pathways are Regulation of TP53 Activity and Gene Expression. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot Summary for NOC2L Gene
Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.