In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In ... See more...

Aliases for NOB1 Gene

Aliases for NOB1 Gene

  • NIN1 (RPN12) Binding Protein 1 Homolog 2 3 5
  • Phosphorylation Regulatory Protein HP-10 3 4
  • NIN1/PSMD8 Binding Protein 1 Homolog 2 3
  • RNA-Binding Protein NOB1 3 4
  • PSMD8 Binding Protein 1 2 3
  • Nin One Binding Protein 2 3
  • Protein ART-4 3 4
  • PSMD8BP1 3 4
  • NOB1P 3 4
  • Adenocarcinoma Antigen Recognized By T Lymphocytes 4 3
  • NIN1/RPN12 Binding Protein 1 Homolog (S. Cerevisiae) 2
  • EC 3.1.-.- 4
  • MSTP158 3
  • MST158 3
  • ART-4 3
  • ART4 4

External Ids for NOB1 Gene

Previous HGNC Symbols for NOB1 Gene

  • PSMD8BP1

Previous GeneCards Identifiers for NOB1 Gene

  • GC16M068334
  • GC16M069775
  • GC16M055654

Summaries for NOB1 Gene

Entrez Gene Summary for NOB1 Gene

  • In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

GeneCards Summary for NOB1 Gene

NOB1 (NIN1 (RPN12) Binding Protein 1 Homolog) is a Protein Coding gene. Diseases associated with NOB1 include Deafness, Autosomal Recessive 89 and Deafness, Autosomal Dominant 40. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression.

UniProtKB/Swiss-Prot Summary for NOB1 Gene

  • May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).

Gene Wiki entry for NOB1 Gene

Additional gene information for NOB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NOB1 Gene

Genomics for NOB1 Gene

GeneHancer (GH) Regulatory Elements for NOB1 Gene

Promoters and enhancers for NOB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NOB1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NOB1

Top Transcription factor binding sites by QIAGEN in the NOB1 gene promoter:
  • AP-1
  • GATA-1
  • GATA-2
  • GATA-3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3

Genomic Locations for NOB1 Gene

Genomic Locations for NOB1 Gene
chr16:69,741,854-69,754,968
(GRCh38/hg38)
Size:
13,115 bases
Orientation:
Minus strand
chr16:69,775,770-69,788,843
(GRCh37/hg19)
Size:
13,074 bases
Orientation:
Minus strand

Genomic View for NOB1 Gene

Genes around NOB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOB1 Gene

Proteins for NOB1 Gene

  • Protein details for NOB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULX3-NOB1_HUMAN
    Recommended name:
    RNA-binding protein NOB1
    Protein Accession:
    Q9ULX3
    Secondary Accessions:
    • Q7L6B7
    • Q7M4M4
    • Q7Z4B5
    • Q9NWB0

    Protein attributes for NOB1 Gene

    Size:
    412 amino acids
    Molecular mass:
    46675 Da
    Quaternary structure:
    • Interacts with UPF2 (Probable). Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex) (PubMed:15231747).
    SequenceCaution:
    • Sequence=AAQ13705.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA91473.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NOB1 Gene

neXtProt entry for NOB1 Gene

Post-translational modifications for NOB1 Gene

  • Ubiquitination at Lys25, Lys40, Lys291, Lys315, Lys333, and Lys358
  • Modification sites at PhosphoSitePlus

Other Protein References for NOB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOB1 Gene

Domains & Families for NOB1 Gene

Gene Families for NOB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOB1 Gene

Blocks:
  • Ankyrin repeat signature
  • Nucleotide binding protein, PINc
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOB1 Gene

GenScript: Design optimal peptide antigens:
  • Protein ART-4 (NOB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULX3

UniProtKB/Swiss-Prot:

NOB1_HUMAN :
  • Belongs to the NOB1 family.
Family:
  • Belongs to the NOB1 family.
genes like me logo Genes that share domains with NOB1: view

Function for NOB1 Gene

Molecular function for NOB1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).
GENATLAS Biochemistry:
new organization associated with HLA-B,gene NOB1

Enzyme Numbers (IUBMB) for NOB1 Gene

Phenotypes From GWAS Catalog for NOB1 Gene

Gene Ontology (GO) - Molecular Function for NOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004521 endoribonuclease activity EXP,IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NOB1: view
genes like me logo Genes that share phenotypes with NOB1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOB1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOB1 Gene

Localization for NOB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOB1 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0030688 preribosome, small subunit precursor IBA 21873635
genes like me logo Genes that share ontologies with NOB1: view

Pathways & Interactions for NOB1 Gene

genes like me logo Genes that share pathways with NOB1: view

Gene Ontology (GO) - Biological Process for NOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000469 cleavage involved in rRNA processing IEA --
GO:0006364 rRNA processing TAS --
GO:0007601 visual perception IEA --
GO:0030490 maturation of SSU-rRNA IBA 21873635
GO:0042274 ribosomal small subunit biogenesis IEA --
genes like me logo Genes that share ontologies with NOB1: view

No data available for SIGNOR curated interactions for NOB1 Gene

Drugs & Compounds for NOB1 Gene

No Compound Related Data Available

Transcripts for NOB1 Gene

mRNA/cDNA for NOB1 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NOB1

Alternative Splicing Database (ASD) splice patterns (SP) for NOB1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:

Relevant External Links for NOB1 Gene

GeneLoc Exon Structure for
NOB1

Expression for NOB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOB1 Gene

Protein differential expression in normal tissues from HIPED for NOB1 Gene

This gene is overexpressed in Breast (46.2) and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOB1 Gene



Protein tissue co-expression partners for NOB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NOB1

SOURCE GeneReport for Unigene cluster for NOB1 Gene:

Hs.271695

mRNA Expression by UniProt/SwissProt for NOB1 Gene:

Q9ULX3-NOB1_HUMAN
Tissue specificity: Detected in liver, lung, placenta, endothelial cells and spleen.

Evidence on tissue expression from TISSUES for NOB1 Gene

  • Intestine(4.3)
  • Kidney(4.3)
  • Liver(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with NOB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOB1 Gene

Orthologs for NOB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOB1 31 30
  • 99.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NOB1 31 30
  • 88.16 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NOB1 31 30
  • 87.78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nob1 30
  • 86.31 (n)
mouse
(Mus musculus)
Mammalia Nob1 17 31 30
  • 85.82 (n)
oppossum
(Monodelphis domestica)
Mammalia NOB1 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOB1 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOB1 31 30
  • 69.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOB1 31
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nob1 30
  • 67.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398701 30
zebrafish
(Danio rerio)
Actinopterygii nob1 31 30
  • 65.76 (n)
OneToOne
wufc27e05 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5629 30
fruit fly
(Drosophila melanogaster)
Insecta CG2972 31 30
  • 54.1 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004064 30
  • 52.13 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54E10BR.4 30
  • 47.97 (n)
Y54E10BR.4 31
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR139W 30
  • 48.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16280g 30
  • 42.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOB1 33 31 30
  • 42.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1867 31
  • 47 (a)
OneToOne
Cin.4034 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1486.09 30
  • 46.5 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08904 30
  • 45.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4034 30
Species where no ortholog for NOB1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOB1 Gene

ENSEMBL:
Gene Tree for NOB1 (if available)
TreeFam:
Gene Tree for NOB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NOB1: view image

Paralogs for NOB1 Gene

Pseudogenes.org Pseudogenes for NOB1 Gene

genes like me logo Genes that share paralogs with NOB1: view

No data available for Paralogs for NOB1 Gene

Variants for NOB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NOB1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
768783 Benign: not provided 69,754,868(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
790167 Likely Benign: not provided 69,752,304(-) T/A SYNONYMOUS_VARIANT
rs1075935 - p.Tyr366Phe
rs3811348 - p.Arg231Gln

Additional dbSNP identifiers (rs#s) for NOB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NOB1 Gene

Variant ID Type Subtype PubMed ID
esv3638928 CNV gain 21293372
esv3638930 CNV gain 21293372
esv3638931 CNV gain 21293372
esv3892878 CNV gain 25118596
nsv524364 CNV loss 19592680

Variation tolerance for NOB1 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.12; 90.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOB1 Gene

Disorders for NOB1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NOB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 89
  • dfnb89
deafness, autosomal dominant 40
  • dfna40
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search NOB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NOB1

genes like me logo Genes that share disorders with NOB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOB1 Gene

Publications for NOB1 Gene

  1. Cloning, expression and characterization of the human NOB1 gene. (PMID: 16172919) Zhang Y … Zhao S (Molecular biology reports 2005) 2 3 4 23 54
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B … Sanderson CM (Genome research 2004) 3 4 54

Products for NOB1 Gene

Sources for NOB1 Gene