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N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include Pellagra and Phototoxic Dermatitis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and nicotinamide N-methyltransferase activity. An important paralog of this gene is INMT.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008112 | nicotinamide N-methyltransferase activity | TAS | -- |
GO:0008168 | methyltransferase activity | IEA | -- |
GO:0008170 | N-methyltransferase activity | IBA | 21873635 |
GO:0016740 | transferase activity | IEA | -- |
GO:0030760 | pyridine N-methyltransferase activity | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
.01
|
|
2 | Viral mRNA Translation | ||
3 | Metabolism |
.40
|
|
4 | NAD metabolism |
NAD metabolism
.53
|
|
5 | Metabolism of water-soluble vitamins and cofactors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010243 | response to organonitrogen compound | IEA | -- |
GO:0031100 | animal organ regeneration | IEA | -- |
GO:0032259 | methylation | TAS | -- |
GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway | TAS | -- |
GO:0042493 | response to drug | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Niacin | Approved, Investigational | Nutra | Agonist, Unknown, Full agonist, Target, binder | 432,432 | ||
Nicotinamide | Approved, Investigational | Pharma | 427,427 | |||
s-adenosylhomocysteine | Experimental | Pharma | 0 | |||
ARI-3037MO | Pharma | inhibitor, agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
s-adenosylmethionine |
|
485-80-3 | ||||
1-Methylnicotinamide |
|
3106-60-3 |
|
|||
Hydrogen Ion |
|
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NNMT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NNMT 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nnmt 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nnmt 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NNMT 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NNMT 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100127789 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC69005 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:64002 31 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | anmt-2 31 |
|
ManyToMany | |
anmt-1 31 |
|
ManyToMany | |||
anmt-3 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3360369 | CNV | duplication | 20981092 |
Disorder | Aliases | PubMed IDs |
---|---|---|
pellagra |
|
|
phototoxic dermatitis |
|
|
clear cell renal cell carcinoma |
|
|
parkinson disease, late-onset |
|
|
kidney cancer |
|
|