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N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include Pellagra and Phototoxic Dermatitis. Among its related pathways are Viral mRNA Translation and NAD metabolism. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and nicotinamide N-methyltransferase activity. An important paralog of this gene is INMT.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008112 | nicotinamide N-methyltransferase activity | TAS | -- |
GO:0008168 | methyltransferase activity | IEA | -- |
GO:0008170 | N-methyltransferase activity | IBA | 21873635 |
GO:0016740 | transferase activity | IEA | -- |
GO:0030760 | pyridine N-methyltransferase activity | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IEA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | NAD metabolism |
NAD metabolism
.53
|
|
2 | Cytochrome P450 - arranged by substrate type |
.01
|
|
3 | Viral mRNA Translation | ||
4 | Metabolism |
.40
|
|
5 | Metabolism of water-soluble vitamins and cofactors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010243 | response to organonitrogen compound | IEA | -- |
GO:0031100 | animal organ regeneration | IEA | -- |
GO:0032259 | methylation | TAS | -- |
GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway | TAS | -- |
GO:0042493 | response to drug | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
s-adenosylmethionine |
|
485-80-3 | ||||
1-Methylnicotinamide |
|
3106-60-3 |
|
|||
Hydrogen Ion |
|
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NNMT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NNMT 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nnmt 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nnmt 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NNMT 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NNMT 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100127789 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC69005 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | zgc:64002 31 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | anmt-2 31 |
|
ManyToMany | |
anmt-1 31 |
|
ManyToMany | |||
anmt-3 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3360369 | CNV | duplication | 20981092 |
Disorder | Aliases | PubMed IDs |
---|---|---|
pellagra |
|
|
phototoxic dermatitis |
|
|
parkinson disease, late-onset |
|
|
lung cancer |
|
|
renal cell carcinoma, nonpapillary |
|
|