External Ids for NNMT Gene
Previous GeneCards Identifiers for NNMT Gene
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
GeneCards Summary for NNMT Gene
NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include Pellagra and Phototoxic Dermatitis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and nicotinamide N-methyltransferase activity. An important paralog of this gene is INMT.
UniProtKB/Swiss-Prot Summary for NNMT Gene
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.