N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008] See more...

Aliases for NNMT Gene

Aliases for NNMT Gene

  • Nicotinamide N-Methyltransferase 2 3 4 5
  • EC 2.1.1.1 4

External Ids for NNMT Gene

Previous GeneCards Identifiers for NNMT Gene

  • GC11P116520
  • GC11P115640
  • GC11P114162
  • GC11P113666
  • GC11P113633
  • GC11P110095

Summaries for NNMT Gene

Entrez Gene Summary for NNMT Gene

  • N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

GeneCards Summary for NNMT Gene

NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include Pellagra and Phototoxic Dermatitis. Among its related pathways are Viral mRNA Translation and NAD metabolism. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and nicotinamide N-methyltransferase activity. An important paralog of this gene is INMT.

UniProtKB/Swiss-Prot Summary for NNMT Gene

  • Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Gene Wiki entry for NNMT Gene

Additional gene information for NNMT Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NNMT Gene

Genomics for NNMT Gene

GeneHancer (GH) Regulatory Elements for NNMT Gene

Promoters and enhancers for NNMT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J114174 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 511.6 -75.8 -75801 14.4 CTCF ZSCAN5C POLR2A TRIM28 REST ATF2 ZNF341 RBM25 FOXA2 NR2F2 NNMT HTR3A ZBTB16 LOC101928875 piR-45576
GH11J114288 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 520.4 +38.4 38414 14.8 TCF12 GTF2E2 JUND POLR2A ZBTB11 MYC EP300 CTBP1 JUN TAF9B NNMT NONHSAG009661.2 ENSG00000256195 C11orf71 ENSG00000255663 RBM7 ZW10 piR-41406-013 ENSG00000256947
GH11J114256 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.0 23 3.5 CTCF ZIC2 ZNF585B WT1 SMC3 POLR2A SPI1 GABPB1 JUND ZFHX2 NNMT lnc-NNMT-1 piR-41406-013 ENSG00000256947 ZBTB16
GH11J114255 Enhancer 0.5 UCNEbase dbSUPER 500.7 -1.9 -1920 0.2 NNMT lnc-NNMT-1 piR-34504 ENSG00000256947 ZBTB16
GH11J114057 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -194.5 -194501 11.2 HNRNPK NRF1 TEAD4 ZNF10 ZIC2 POLR2A ZBTB10 ZBTB26 EZH2 ZNF341 ZBTB16 lnc-USP28-5 NNMT lnc-USP28-6 RF00017-1033
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NNMT on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NNMT

Top Transcription factor binding sites by QIAGEN in the NNMT gene promoter:
  • Brachyury
  • FOXC1
  • GATA-1
  • GATA-2
  • GATA-3
  • HNF-3beta
  • SEF-1 (1)
  • STAT6

Genomic Locations for NNMT Gene

Genomic Locations for NNMT Gene
chr11:114,257,787-114,313,285
(GRCh38/hg38)
Size:
55,499 bases
Orientation:
Plus strand
chr11:114,128,509-114,184,007
(GRCh37/hg19)
Size:
55,499 bases
Orientation:
Plus strand

Genomic View for NNMT Gene

Genes around NNMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NNMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NNMT Gene

Proteins for NNMT Gene

  • Protein details for NNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40261-NNMT_HUMAN
    Recommended name:
    Nicotinamide N-methyltransferase
    Protein Accession:
    P40261

    Protein attributes for NNMT Gene

    Size:
    264 amino acids
    Molecular mass:
    29574 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NNMT Gene

neXtProt entry for NNMT Gene

Post-translational modifications for NNMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NNMT Gene

No data available for DME Specific Peptides for NNMT Gene

Domains & Families for NNMT Gene

Gene Families for NNMT Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NNMT Gene

Blocks:
  • Methyltransferase, NNMT/PNMT/TEMT family
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NNMT Gene

GenScript: Design optimal peptide antigens:
  • Nicotinamide N-methyltransferase (NNMT_HUMAN)
  • Nicotinamide N-methyltransferase, isoform CRA_a (Q6FH49_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P40261

UniProtKB/Swiss-Prot:

NNMT_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
genes like me logo Genes that share domains with NNMT: view

Function for NNMT Gene

Molecular function for NNMT Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:23884, ChEBI:CHEBI:16797, ChEBI:CHEBI:17154, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.1;.
GENATLAS Biochemistry:
nicotinamide N-methyltransferase

Enzyme Numbers (IUBMB) for NNMT Gene

Phenotypes From GWAS Catalog for NNMT Gene

Gene Ontology (GO) - Molecular Function for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008112 nicotinamide N-methyltransferase activity TAS --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0030760 pyridine N-methyltransferase activity TAS --
genes like me logo Genes that share ontologies with NNMT: view
genes like me logo Genes that share phenotypes with NNMT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NNMT

Clone Products

  • Addgene plasmids for NNMT

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NNMT Gene

Localization for NNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NNMT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NNMT gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NNMT: view

Pathways & Interactions for NNMT Gene

genes like me logo Genes that share pathways with NNMT: view

Pathways by source for NNMT Gene

Gene Ontology (GO) - Biological Process for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010243 response to organonitrogen compound IEA --
GO:0031100 animal organ regeneration IEA --
GO:0032259 methylation TAS --
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with NNMT: view

No data available for SIGNOR curated interactions for NNMT Gene

Drugs & Compounds for NNMT Gene

(5) Drugs for NNMT Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist, Full agonist, Target, binder 530,530
Nicotinamide Approved, Investigational Pharma 526,526
s-adenosylhomocysteine Experimental Pharma 0
ARI-3037MO Pharma inhibitor, agonist 0

(10) Additional Compounds for NNMT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
1-Methylnicotinamide
  • 1-Methylnicotinamide cation
  • 3-(Aminocarbonyl)-1-methylpyridinium
  • N(1)-Methylnicotinamide
  • Trigonellinamide
  • 1-Methyl-3-carbamoylpyridinium
3106-60-3
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with NNMT: view

Transcripts for NNMT Gene

mRNA/cDNA for NNMT Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for NNMT

Alternative Splicing Database (ASD) splice patterns (SP) for NNMT Gene

No ASD Table

Relevant External Links for NNMT Gene

GeneLoc Exon Structure for
NNMT

Expression for NNMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NNMT Gene

This gene is overexpressed in Liver (x13.7).

Protein differential expression in normal tissues from HIPED for NNMT Gene

This gene is overexpressed in Liver (15.2) and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NNMT Gene



Protein tissue co-expression partners for NNMT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NNMT

SOURCE GeneReport for Unigene cluster for NNMT Gene:

Hs.503911

mRNA Expression by UniProt/SwissProt for NNMT Gene:

P40261-NNMT_HUMAN
Tissue specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.

Evidence on tissue expression from TISSUES for NNMT Gene

  • Liver(5)
  • Eye(4.2)
  • Lung(3.2)
  • Bone(3.1)
  • Kidney(2.8)
  • Nervous system(2.6)
  • Intestine(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with NNMT: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NNMT Gene

Orthologs for NNMT Gene

This gene was present in the common ancestor of animals.

Orthologs for NNMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NNMT 31 30
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NNMT 31 30
  • 85.98 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nnmt 30
  • 83.91 (n)
mouse
(Mus musculus)
Mammalia Nnmt 17 31 30
  • 82.95 (n)
oppossum
(Monodelphis domestica)
Mammalia NNMT 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NNMT 31
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 52 (a)
ManyToMany
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 50 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127789 30
  • 52.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69005 30
zebrafish
(Danio rerio)
Actinopterygii zgc:64002 31 31
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea anmt-2 31
  • 23 (a)
ManyToMany
anmt-1 31
  • 23 (a)
ManyToMany
anmt-3 31
  • 22 (a)
ManyToMany
Species where no ortholog for NNMT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NNMT Gene

ENSEMBL:
Gene Tree for NNMT (if available)
TreeFam:
Gene Tree for NNMT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NNMT: view image

Paralogs for NNMT Gene

Paralogs for NNMT Gene

(3) SIMAP similar genes for NNMT Gene using alignment to 3 proteins:

  • NNMT_HUMAN
  • F5H0R4_HUMAN
  • Q6FH49_HUMAN

Pseudogenes.org Pseudogenes for NNMT Gene

genes like me logo Genes that share paralogs with NNMT: view

Variants for NNMT Gene

Additional dbSNP identifiers (rs#s) for NNMT Gene

Structural Variations from Database of Genomic Variants (DGV) for NNMT Gene

Variant ID Type Subtype PubMed ID
esv3360369 CNV duplication 20981092

Variation tolerance for NNMT Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NNMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NNMT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NNMT Gene

Disorders for NNMT Gene

MalaCards: The human disease database

(6) MalaCards diseases for NNMT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pellagra
  • niacin deficiency
phototoxic dermatitis
  • photosensitisation reaction
kidney cancer
  • renal cell carcinoma
parkinson disease, late-onset
  • pd
thyroid gland cancer
  • malignant neoplasm of thyroid gland
- elite association - COSMIC cancer census association via MalaCards
Search NNMT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NNMT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NNMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NNMT Gene

Publications for NNMT Gene

  1. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. (PMID: 8575745) Aksoy S … Weinshilboum RM (Genomics 1995) 2 3 4 23 54
  2. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. (PMID: 19020309) de Jonge R … Pieters R (Blood 2009) 3 23 41 54
  3. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. (PMID: 18996527) Riederer M … Zechner R (Atherosclerosis 2009) 3 23 26 54
  4. High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. (PMID: 18427977) Giusti B … Abbate R (Biochemical genetics 2008) 3 23 41 54
  5. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (PMID: 18635682) Giusti B … Abbate R (Journal of medical genetics 2008) 3 23 41 54

Products for NNMT Gene

Sources for NNMT Gene