Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NNMT Gene

Aliases for NNMT Gene

  • Nicotinamide N-Methyltransferase 2 3 5
  • EC 2.1.1.1 4

External Ids for NNMT Gene

Previous GeneCards Identifiers for NNMT Gene

  • GC11P116520
  • GC11P115640
  • GC11P114162
  • GC11P113666
  • GC11P113633
  • GC11P110095

Summaries for NNMT Gene

Entrez Gene Summary for NNMT Gene

  • N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

GeneCards Summary for NNMT Gene

NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include Kidney Cancer and Parkinson Disease, Late-Onset. Among its related pathways are Cytochrome P450 - arranged by substrate type and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and nicotinamide N-methyltransferase activity. An important paralog of this gene is INMT.

UniProtKB/Swiss-Prot for NNMT Gene

  • Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Gene Wiki entry for NNMT Gene

Additional gene information for NNMT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NNMT Gene

Genomics for NNMT Gene

GeneHancer (GH) Regulatory Elements for NNMT Gene

Promoters and enhancers for NNMT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I114288 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 570.4 +37.7 37667 13.1 FOXA2 PKNOX1 ATF1 SIN3A BRCA1 YY1 TCF12 ATF7 FOS RXRA NNMT LOC101928940 RBM7 C11orf71 ENSG00000255663 ZW10 GC11P114306 GC11M114263 ENSG00000256947
GH11I114256 Enhancer 1.2 Ensembl ENCODE dbSUPER 550.8 +0.2 166 3.3 FEZF1 THRB RAD21 GLIS2 ZNF213 ZSCAN5C EGR2 RXRA ZNF398 ZNF488 NNMT GC11M114263 ENSG00000256947
GH11I114255 Enhancer 0.6 UCNEbase dbSUPER 550.8 -1.9 -1920 0.2 NNMT PIR57549 ENSG00000256947
GH11I114057 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -194.5 -194501 11.2 KLF17 ZNF76 SIN3A GLI4 RAD21 YY1 ZNF335 GLIS2 SCRT2 EGR2 ZBTB16 GC11M114060 NNMT LOC101928875
GH11I114152 Enhancer 2.2 UCNEbase FANTOM5 Ensembl ENCODE dbSUPER 10.8 -94.2 -94164 22.1 FOXA2 SMAD1 ARNT ARID4B FEZF1 ZNF2 YY1 CBX5 ZNF213 E2F8 ENSG00000270179 ZBTB16 NNMT LOC105369499 TTC12 ZW10 CLDN25 LOC101928875 GC11M114060
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NNMT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NNMT gene promoter:

Genomic Locations for NNMT Gene

Genomic Locations for NNMT Gene
chr11:114,257,787-114,313,285
(GRCh38/hg38)
Size:
55,499 bases
Orientation:
Plus strand
chr11:114,128,509-114,184,007
(GRCh37/hg19)

Genomic View for NNMT Gene

Genes around NNMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NNMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NNMT Gene

Proteins for NNMT Gene

  • Protein details for NNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40261-NNMT_HUMAN
    Recommended name:
    Nicotinamide N-methyltransferase
    Protein Accession:
    P40261

    Protein attributes for NNMT Gene

    Size:
    264 amino acids
    Molecular mass:
    29574 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NNMT Gene

neXtProt entry for NNMT Gene

Post-translational modifications for NNMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NNMT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NNMT Gene

Domains & Families for NNMT Gene

Gene Families for NNMT Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NNMT Gene

Graphical View of Domain Structure for InterPro Entry

P40261

UniProtKB/Swiss-Prot:

NNMT_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
genes like me logo Genes that share domains with NNMT: view

Function for NNMT Gene

Molecular function for NNMT Gene

GENATLAS Biochemistry:
nicotinamide N-methyltransferase
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
UniProtKB/Swiss-Prot Function:
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Enzyme Numbers (IUBMB) for NNMT Gene

Phenotypes From GWAS Catalog for NNMT Gene

Gene Ontology (GO) - Molecular Function for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008112 nicotinamide N-methyltransferase activity TAS --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0030760 pyridine N-methyltransferase activity TAS --
genes like me logo Genes that share ontologies with NNMT: view
genes like me logo Genes that share phenotypes with NNMT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NNMT

Clone Products

  • Addgene plasmids for NNMT

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NNMT Gene

Localization for NNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NNMT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NNMT gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NNMT: view

Pathways & Interactions for NNMT Gene

genes like me logo Genes that share pathways with NNMT: view

Pathways by source for NNMT Gene

Gene Ontology (GO) - Biological Process for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010243 response to organonitrogen compound IEA --
GO:0031100 animal organ regeneration IEA --
GO:0032259 methylation TAS --
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with NNMT: view

No data available for SIGNOR curated interactions for NNMT Gene

Drugs & Compounds for NNMT Gene

(5) Drugs for NNMT Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist, Target, binder 946,946
Nicotinamide Approved, Investigational Nutra 942,946
s-adenosylhomocysteine Experimental Pharma 0
ARI-3037MO Pharma inhibitor, agonist 0

(10) Additional Compounds for NNMT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
1-Methylnicotinamide
  • 1-Methyl-3-carbamoylpyridinium
  • 1-Methyl-3-carbamoylpyridinium cation
  • 1-Methylnicotinamide
  • 3-Amido-N-methylpyridinium: 1-methyl-3-Pyridinecarboxamide
  • 3-Carbamoyl-1-methyl-Pyridinium
3106-60-3
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with NNMT: view

Transcripts for NNMT Gene

Unigene Clusters for NNMT Gene

Nicotinamide N-methyltransferase:
Representative Sequences:

Clone Products

  • Addgene plasmids for NNMT

Alternative Splicing Database (ASD) splice patterns (SP) for NNMT Gene

No ASD Table

Relevant External Links for NNMT Gene

GeneLoc Exon Structure for
NNMT
ECgene alternative splicing isoforms for
NNMT

Expression for NNMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NNMT Gene

This gene is overexpressed in Liver (x13.7).

Protein differential expression in normal tissues from HIPED for NNMT Gene

This gene is overexpressed in Liver (15.2) and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NNMT Gene



Protein tissue co-expression partners for NNMT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NNMT Gene:

NNMT

SOURCE GeneReport for Unigene cluster for NNMT Gene:

Hs.503911

mRNA Expression by UniProt/SwissProt for NNMT Gene:

P40261-NNMT_HUMAN
Tissue specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.

Evidence on tissue expression from TISSUES for NNMT Gene

  • Liver(5)
  • Eye(4.2)
  • Lung(3.2)
  • Bone(3.1)
  • Kidney(2.8)
  • Nervous system(2.6)
  • Intestine(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with NNMT: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NNMT Gene

Orthologs for NNMT Gene

This gene was present in the common ancestor of animals.

Orthologs for NNMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NNMT 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia NNMT 33 34
  • 85.98 (n)
rat
(Rattus norvegicus)
Mammalia Nnmt 33
  • 83.91 (n)
mouse
(Mus musculus)
Mammalia Nnmt 33 16 34
  • 82.95 (n)
oppossum
(Monodelphis domestica)
Mammalia NNMT 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NNMT 34
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127789 33
  • 52.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69005 33
zebrafish
(Danio rerio)
Actinopterygii zgc:64002 34 34
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea anmt-1 34
  • 23 (a)
ManyToMany
anmt-2 34
  • 23 (a)
ManyToMany
anmt-3 34
  • 22 (a)
ManyToMany
Species where no ortholog for NNMT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NNMT Gene

ENSEMBL:
Gene Tree for NNMT (if available)
TreeFam:
Gene Tree for NNMT (if available)

Paralogs for NNMT Gene

Paralogs for NNMT Gene

(3) SIMAP similar genes for NNMT Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NNMT Gene

genes like me logo Genes that share paralogs with NNMT: view

Variants for NNMT Gene

Sequence variations from dbSNP and Humsavar for NNMT Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000017941 -- 114,308,625(+) T/A intron_variant
rs1000225329 -- 114,294,802(+) AAAAAAAAA/AAAAAAAAAA upstream_transcript_variant
rs1000292553 -- 114,309,693(+) A/T intron_variant
rs1000494408 -- 114,308,392(+) C/T intron_variant
rs1000594298 -- 114,303,049(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NNMT Gene

Variant ID Type Subtype PubMed ID
esv3360369 CNV duplication 20981092

Variation tolerance for NNMT Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NNMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NNMT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NNMT Gene

Disorders for NNMT Gene

MalaCards: The human disease database

(4) MalaCards diseases for NNMT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kidney cancer
  • malignant neoplasm of kidney except pelvis
parkinson disease, late-onset
  • pd
thyroid cancer, nonmedullary, 1
  • nmtc1
renal cell carcinoma, nonpapillary
  • rcc
- elite association - COSMIC cancer census association via MalaCards
Search NNMT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NNMT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NNMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NNMT Gene

Publications for NNMT Gene

  1. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. (PMID: 8575745) Aksoy S … Weinshilboum RM (Genomics 1995) 2 3 4 22 58
  2. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. (PMID: 18996527) Riederer M … Zechner R (Atherosclerosis 2009) 3 22 25 58
  3. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. (PMID: 19020309) de Jonge R … Pieters R (Blood 2009) 3 22 44 58
  4. High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. (PMID: 18427977) Giusti B … Abbate R (Biochemical genetics 2008) 3 22 44 58
  5. Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide. (PMID: 18441319) van Driel LM … Steegers-Theunissen RP (European heart journal 2008) 3 22 44 58

Products for NNMT Gene

  • Addgene plasmids for NNMT

Sources for NNMT Gene

Content
Loading form....