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The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of another gene, bladder cancer associated protein, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. [provided by RefSeq, Apr 2016]
NNAT (Neuronatin) is a Protein Coding gene. Diseases associated with NNAT include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1 and Myopathy, Centronuclear, 6, With Fiber-Type Disproportion.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007420 | brain development | IEA,IBA | 21873635 |
GO:0009249 | protein lipoylation | TAS | 8813377 |
GO:0030182 | neuron differentiation | IEA | -- |
GO:0032024 | positive regulation of insulin secretion | IBA | 21873635 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | - | |||||||||||
SP3: | - |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NNAT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NNAT 31 |
|
OneToOne | |
LOC609195 30 |
|
||||
Mouse (Mus musculus) |
Mammalia | Nnat 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nnat 30 |
|
||
Cow (Bos Taurus) |
Mammalia | NNAT 30 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1055206 | CNV | loss | 25217958 |
nsv585962 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
megalencephalic leukoencephalopathy with subcortical cysts 1 |
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myopathy, centronuclear, 6, with fiber-type disproportion |
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myoclonic epilepsy of lafora |
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transient neonatal diabetes mellitus |
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silver-russell syndrome 1 |
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