This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008] See more...

Aliases for NMUR2 Gene

Aliases for NMUR2 Gene

  • Neuromedin U Receptor 2 2 3 5
  • G-Protein Coupled Receptor TGR-1 3 4
  • G-Protein Coupled Receptor FM-4 3 4
  • Neuromedin-U Receptor 2 3 4
  • NMU-R2 3 4
  • NMU2R 3 4
  • TGR1 3 4
  • Growth Hormone Secretagogue Receptor Family, Member 4 3
  • TGR-1 3
  • FM-4 3
  • FM4 3

External Ids for NMUR2 Gene

Previous HGNC Symbols for NMUR2 Gene

  • NMU2R

Previous GeneCards Identifiers for NMUR2 Gene

  • GC05M151801
  • GC05M151751
  • GC05M146910

Summaries for NMUR2 Gene

Entrez Gene Summary for NMUR2 Gene

  • This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

GeneCards Summary for NMUR2 Gene

NMUR2 (Neuromedin U Receptor 2) is a Protein Coding gene. Diseases associated with NMUR2 include Myasthenic Syndrome, Congenital, 4C, Associated With Acetylcholine Receptor Deficiency and Robinow Syndrome, Autosomal Dominant 2. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NMUR1.

UniProtKB/Swiss-Prot Summary for NMUR2 Gene

Tocris Summary for NMUR2 Gene

  • Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes: NMU1 and NMU2. The two subtypes have distinct tissue distributions: NMU1 is expressed in the periphery, whilst NMU2 is expressed in the CNS.

Gene Wiki entry for NMUR2 Gene

Additional gene information for NMUR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NMUR2 Gene

Genomics for NMUR2 Gene

GeneHancer (GH) Regulatory Elements for NMUR2 Gene

Promoters and enhancers for NMUR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J152405 Promoter 0.7 EPDnew Ensembl 524.3 +28.0 27967 0.4 NMUR2 piR-49802 lnc-NMUR2-2 ENSG00000286749
GH05J152462 Enhancer 0.5 Ensembl 13.3 -29.0 -29032 0.4 CTCF SMC3 PAX5 RAD21 TBX21 SMARCA4 SPI1 ZNF143 NMUR2 piR-56451-086 piR-34822-271 ENSG00000286749
GH05J152288 Enhancer 0.4 Ensembl 14 +144.5 144467 1 NR2F2 FOXA1 RXRA NMUR2 HSALNG0045947 RF00994-870
GH05J152437 Enhancer 0.4 Ensembl 13.6 -4.7 -4733 1 HDAC2 YY1 SP1 NMUR2 lnc-NMUR2-2 piR-34822-271 ENSG00000286749
GH05J152527 Enhancer 0.6 Ensembl ENCODE 8.2 -95.6 -95632 3.6 USF1 JUND BATF ETV6 NMUR2 RPL36AP20 lnc-NMUR2-3 piR-48553-260 ENSG00000286749
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMUR2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NMUR2

Top Transcription factor binding sites by QIAGEN in the NMUR2 gene promoter:
  • Brachyury
  • c-Myc
  • CUTL1
  • En-1
  • Evi-1
  • Ik-3
  • LyF-1
  • Max1
  • MRF-2

Genomic Locations for NMUR2 Gene

Genomic Locations for NMUR2 Gene
chr5:152,391,532-152,433,368
(GRCh38/hg38)
Size:
41,837 bases
Orientation:
Minus strand
chr5:151,771,093-151,812,929
(GRCh37/hg19)
Size:
41,837 bases
Orientation:
Minus strand

Genomic View for NMUR2 Gene

Genes around NMUR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMUR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMUR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMUR2 Gene

Proteins for NMUR2 Gene

  • Protein details for NMUR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ4-NMUR2_HUMAN
    Recommended name:
    Neuromedin-U receptor 2
    Protein Accession:
    Q9GZQ4
    Secondary Accessions:
    • Q7LC54
    • Q96AM5
    • Q9NRA6

    Protein attributes for NMUR2 Gene

    Size:
    415 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13721.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for NMUR2 Gene

Post-translational modifications for NMUR2 Gene

  • Glycosylation at Asn9, Asn27, and Asn194
  • Modification sites at PhosphoSitePlus

Other Protein References for NMUR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMUR2 Gene

Domains & Families for NMUR2 Gene

Gene Families for NMUR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for NMUR2 Gene

Blocks:
  • Neuromedin U receptor family signature
  • Neuromedin U type 2 receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NMUR2 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor TGR-1 (NMUR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZQ4

UniProtKB/Swiss-Prot:

NMUR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NMUR2: view

Function for NMUR2 Gene

Molecular function for NMUR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Phenotypes From GWAS Catalog for NMUR2 Gene

Gene Ontology (GO) - Molecular Function for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001607 neuromedin U receptor activity IDA 10887190
GO:0004930 G protein-coupled receptor activity TAS 10894543
GO:0005229 intracellular calcium activated chloride channel activity IDA 10899166
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IDA 10899166
genes like me logo Genes that share ontologies with NMUR2: view
genes like me logo Genes that share phenotypes with NMUR2: view

Animal Models for NMUR2 Gene

MGI Knock Outs for NMUR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NMUR2

CRISPR Products

Clone Products

  • Addgene plasmids for NMUR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NMUR2 Gene

Localization for NMUR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMUR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMUR2 gene
Compartment Confidence
plasma membrane 5
endosome 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 10899166
genes like me logo Genes that share ontologies with NMUR2: view

Pathways & Interactions for NMUR2 Gene

genes like me logo Genes that share pathways with NMUR2: view

SIGNOR curated interactions for NMUR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002023 reduction of food intake in response to dietary excess IEA --
GO:0006816 calcium ion transport IDA 10899166
GO:0006940 regulation of smooth muscle contraction NAS 10887190
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NMUR2: view

Drugs & Compounds for NMUR2 Gene

(11) Drugs for NMUR2 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Neuromedin S (rat) Pharma Potent, endogenous NMU1 and NMU2 agonist 0
[<sup>125</sup>I]neuromedin U-23 (rat) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-25 (human) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-8 (pig) Pharma Agonist 0
neuromedin S-33 Pharma Full agonist, Agonist 0

(2) Tocris Compounds for NMUR2 Gene

Compound Action Cas Number
Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist 843782-19-4
Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature 117505-80-3

(1) ApexBio Compounds for NMUR2 Gene

Compound Action Cas Number
Neuromedin S (rat) 843782-19-4
genes like me logo Genes that share compounds with NMUR2: view

Drug Products

Transcripts for NMUR2 Gene

mRNA/cDNA for NMUR2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NMUR2

Alternative Splicing Database (ASD) splice patterns (SP) for NMUR2 Gene

No ASD Table

Relevant External Links for NMUR2 Gene

GeneLoc Exon Structure for
NMUR2

Expression for NMUR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NMUR2 Gene

mRNA differential expression in normal tissues according to GTEx for NMUR2 Gene

This gene is overexpressed in Testis (x10.2), Brain - Spinal cord (cervical c-1) (x8.5), and Brain - Hypothalamus (x6.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NMUR2

SOURCE GeneReport for Unigene cluster for NMUR2 Gene:

Hs.731911

mRNA Expression by UniProt/SwissProt for NMUR2 Gene:

Q9GZQ4-NMUR2_HUMAN
Tissue specificity: Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.

Evidence on tissue expression from TISSUES for NMUR2 Gene

  • Intestine(4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with NMUR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMUR2 Gene

Orthologs for NMUR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMUR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMUR2 31 30
  • 98.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NMUR2 31 30
  • 87.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NMUR2 31 30
  • 85.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nmur2 17 31 30
  • 81.39 (n)
rat
(Rattus norvegicus)
Mammalia Nmur2 30
  • 80.76 (n)
oppossum
(Monodelphis domestica)
Mammalia NMUR2 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMUR2 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMUR2 31 30
  • 71.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMUR2 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmur2 30
  • 67.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC566750 30
  • 57.97 (n)
BX248318.1 31
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta capaR 31 30
  • 49.58 (n)
ManyToMany
Pk1r 31
  • 27 (a)
ManyToMany
CG8795 31
  • 19 (a)
ManyToMany
CG8784 31
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nmur-1 31 30
  • 45.75 (n)
ManyToMany
nmur-2 31
  • 30 (a)
ManyToMany
nmur-4 31
  • 25 (a)
ManyToMany
nmur-3 31
  • 20 (a)
ManyToMany
Species where no ortholog for NMUR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMUR2 Gene

ENSEMBL:
Gene Tree for NMUR2 (if available)
TreeFam:
Gene Tree for NMUR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMUR2: view image

Paralogs for NMUR2 Gene

(9) SIMAP similar genes for NMUR2 Gene using alignment to 1 proteins:

  • NMUR2_HUMAN
genes like me logo Genes that share paralogs with NMUR2: view

Variants for NMUR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NMUR2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
764858 Likely Benign: not provided 152,404,651(-) T/C MISSENSE_VARIANT
764859 Likely Benign: not provided 152,404,655(-) GCGGAA/G FRAMESHIFT_VARIANT
777808 Benign: not provided 152,392,467(-) G/T SYNONYMOUS_VARIANT
780588 Benign: not provided 152,395,580(-) G/A SYNONYMOUS_VARIANT
rs1363422 - p.Ala395Thr

Additional dbSNP identifiers (rs#s) for NMUR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NMUR2 Gene

Variant ID Type Subtype PubMed ID
dgv1658e212 CNV loss 25503493
esv2763511 CNV loss 21179565
nsv1023828 CNV gain 25217958
nsv830519 CNV loss 17160897

Variation tolerance for NMUR2 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMUR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMUR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMUR2 Gene

Disorders for NMUR2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NMUR2 Gene - From: DISEASES and Novoseek

- elite association - COSMIC cancer census association via MalaCards
Search NMUR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NMUR2

genes like me logo Genes that share disorders with NMUR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMUR2 Gene

Publications for NMUR2 Gene

  1. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. (PMID: 11010960) Shan L … Hedrick JA (The Journal of biological chemistry 2000) 3 4 23 54
  2. Identification of receptors for neuromedin U and its role in feeding. (PMID: 10894543) Howard AD … Liu Q (Nature 2000) 2 3 4 54
  3. Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones. (PMID: 16781063) Fang L … Hu Y (Neuroscience letters 2006) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. (PMID: 15525579) Bhattacharyya S … O'Rahilly S (The Journal of endocrinology 2004) 3 23 54

Products for NMUR2 Gene

Sources for NMUR2 Gene