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Aliases for NMUR2 Gene

Aliases for NMUR2 Gene

  • Neuromedin U Receptor 2 2 3 5
  • G-Protein Coupled Receptor TGR-1 3 4
  • G-Protein Coupled Receptor FM-4 3 4
  • NMU-R2 3 4
  • NMU2R 3 4
  • TGR1 3 4
  • Growth Hormone Secretagogue Receptor Family, Member 4 3
  • Neuromedin-U Receptor 2 3
  • TGR-1 3
  • FM-4 3
  • FM4 3

External Ids for NMUR2 Gene

Previous HGNC Symbols for NMUR2 Gene

  • NMU2R

Previous GeneCards Identifiers for NMUR2 Gene

  • GC05M151801
  • GC05M151751
  • GC05M146910

Summaries for NMUR2 Gene

Entrez Gene Summary for NMUR2 Gene

  • This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

GeneCards Summary for NMUR2 Gene

NMUR2 (Neuromedin U Receptor 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is NMUR1.

UniProtKB/Swiss-Prot for NMUR2 Gene

  • Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Tocris Summary for NMUR2 Gene

  • Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes: NMU1 and NMU2. The two subtypes have distinct tissue distributions: NMU1 is expressed in the periphery, whilst NMU2 is expressed in the CNS.

Gene Wiki entry for NMUR2 Gene

Additional gene information for NMUR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMUR2 Gene

Genomics for NMUR2 Gene

GeneHancer (GH) Regulatory Elements for NMUR2 Gene

Promoters and enhancers for NMUR2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J152405 Promoter 0.5 EPDnew 661.4 +28.1 28069 0.1 NMUR2 PIR42801 GC05P152406 GC05P152405
GH05J152422 Enhancer 0.2 FANTOM5 0.4 +11.1 11117 0.2 GC05M152425 NMUR2 GC05P152406
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMUR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NMUR2 gene promoter:
  • LyF-1
  • Ik-3
  • Evi-1
  • MRF-2
  • Max1
  • c-Myc
  • En-1
  • Brachyury
  • CUTL1

Genomic Locations for NMUR2 Gene

Genomic Locations for NMUR2 Gene
41,837 bases
Minus strand
41,837 bases
Minus strand

Genomic View for NMUR2 Gene

Genes around NMUR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMUR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMUR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMUR2 Gene

Proteins for NMUR2 Gene

  • Protein details for NMUR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuromedin-U receptor 2
    Protein Accession:
    Secondary Accessions:
    • Q7LC54
    • Q96AM5
    • Q9NRA6

    Protein attributes for NMUR2 Gene

    415 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NMUR2 Gene

Post-translational modifications for NMUR2 Gene

  • Glycosylation at isoforms=194, isoforms=27, and isoforms=9
  • Modification sites at PhosphoSitePlus

Other Protein References for NMUR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMUR2 Gene

Domains & Families for NMUR2 Gene

Gene Families for NMUR2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for NMUR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NMUR2: view

Function for NMUR2 Gene

Molecular function for NMUR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Phenotypes From GWAS Catalog for NMUR2 Gene

Gene Ontology (GO) - Molecular Function for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001607 neuromedin U receptor activity IDA 10887190
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 10894543
GO:0005229 intracellular calcium activated chloride channel activity IDA 10899166
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NMUR2: view
genes like me logo Genes that share phenotypes with NMUR2: view

Animal Models for NMUR2 Gene

MGI Knock Outs for NMUR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NMUR2

Clone Products

  • Addgene plasmids for NMUR2
  • R&D Systems cDNA Clones for NMUR2 (Neuromedin U R2/NMUR2)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NMUR2 Gene

Localization for NMUR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMUR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMUR2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
endosome 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 10899166
genes like me logo Genes that share ontologies with NMUR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NMUR2 Gene

Pathways & Interactions for NMUR2 Gene

genes like me logo Genes that share pathways with NMUR2: view

SIGNOR curated interactions for NMUR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002023 reduction of food intake in response to dietary excess IEA --
GO:0006816 calcium ion transport IDA 10899166
GO:0006940 regulation of smooth muscle contraction NAS 10887190
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NMUR2: view

Drugs & Compounds for NMUR2 Gene

(11) Drugs for NMUR2 Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Neuromedin S (rat) Pharma Potent, endogenous NMU1 and NMU2 agonist 0
[<sup>125</sup>I]neuromedin U-23 (rat) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-25 (human) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-8 (pig) Pharma Agonist 0
neuromedin S-33 Pharma Full agonist, Agonist 0

(2) Tocris Compounds for NMUR2 Gene

Compound Action Cas Number
Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist 843782-19-4
Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature 117505-80-3
genes like me logo Genes that share compounds with NMUR2: view

Transcripts for NMUR2 Gene

mRNA/cDNA for NMUR2 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NMUR2 Gene

Neuromedin U receptor 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for NMUR2
  • R&D Systems cDNA Clones for NMUR2 (Neuromedin U R2/NMUR2)

Alternative Splicing Database (ASD) splice patterns (SP) for NMUR2 Gene

No ASD Table

Relevant External Links for NMUR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NMUR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMUR2 Gene

mRNA differential expression in normal tissues according to GTEx for NMUR2 Gene

This gene is overexpressed in Testis (x10.2), Brain - Spinal cord (cervical c-1) (x8.5), and Brain - Hypothalamus (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of NMUR2 Gene:


SOURCE GeneReport for Unigene cluster for NMUR2 Gene:


mRNA Expression by UniProt/SwissProt for NMUR2 Gene:

Tissue specificity: Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.

Evidence on tissue expression from TISSUES for NMUR2 Gene

  • Intestine(4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with NMUR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMUR2 Gene

Orthologs for NMUR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMUR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NMUR2 34 33
  • 98.55 (n)
(Canis familiaris)
Mammalia NMUR2 34 33
  • 87.7 (n)
(Bos Taurus)
Mammalia NMUR2 34 33
  • 85.79 (n)
(Mus musculus)
Mammalia Nmur2 16 34 33
  • 81.39 (n)
(Rattus norvegicus)
Mammalia Nmur2 33
  • 80.76 (n)
(Monodelphis domestica)
Mammalia NMUR2 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia NMUR2 34
  • 71 (a)
(Gallus gallus)
Aves NMUR2 34 33
  • 71.66 (n)
(Anolis carolinensis)
Reptilia NMUR2 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nmur2 33
  • 67.77 (n)
(Danio rerio)
Actinopterygii LOC566750 33
  • 57.97 (n)
BX248318.1 34
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta capaR 34 33
  • 49.58 (n)
Pk1r 34
  • 27 (a)
CG8795 34
  • 19 (a)
CG8784 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea nmur-1 34 33
  • 45.75 (n)
nmur-2 34
  • 30 (a)
nmur-4 34
  • 25 (a)
nmur-3 34
  • 20 (a)
Species where no ortholog for NMUR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMUR2 Gene

Gene Tree for NMUR2 (if available)
Gene Tree for NMUR2 (if available)
Evolutionary constrained regions (ECRs) for NMUR2: view image

Paralogs for NMUR2 Gene

Paralogs for NMUR2 Gene

(9) SIMAP similar genes for NMUR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NMUR2: view

Variants for NMUR2 Gene

Sequence variations from dbSNP and Humsavar for NMUR2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000565906 -- 152,405,805(-) C/T upstream_transcript_variant
rs1000622662 -- 152,401,416(-) T/C intron_variant
rs1000895609 -- 152,395,068(-) A/T intron_variant
rs1000914600 -- 152,406,780(-) TTT/TT upstream_transcript_variant
rs1001345424 -- 152,395,166(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NMUR2 Gene

Variant ID Type Subtype PubMed ID
dgv1658e212 CNV loss 25503493
esv2763511 CNV loss 21179565
nsv1023828 CNV gain 25217958
nsv830519 CNV loss 17160897

Variation tolerance for NMUR2 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMUR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMUR2 Gene

Disorders for NMUR2 Gene

Additional Disease Information for NMUR2

No disorders were found for NMUR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMUR2 Gene

Publications for NMUR2 Gene

  1. Identification of receptors for neuromedin U and its role in feeding. (PMID: 10894543) Howard AD … Liu Q (Nature 2000) 2 3 4 58
  2. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. (PMID: 11010960) Shan L … Hedrick JA (The Journal of biological chemistry 2000) 3 4 22 58
  3. Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones. (PMID: 16781063) Fang L … Hu Y (Neuroscience letters 2006) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. (PMID: 15525579) Bhattacharyya S … O'Rahilly S (The Journal of endocrinology 2004) 3 22 58

Products for NMUR2 Gene

Sources for NMUR2 Gene

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