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Aliases for NMU Gene

Aliases for NMU Gene

  • Neuromedin U 2 3 5
  • Neuromedin-U 3 4
  • Prepro-NMU 2 3
  • Neuromedin U Precursor-Related Peptide/Neuromedin U Preproprotein 3

External Ids for NMU Gene

Previous GeneCards Identifiers for NMU Gene

  • GC04M056265
  • GC04M056422
  • GC04M056311
  • GC04M056376
  • GC04M056302
  • GC04M056156
  • GC04M056461
  • GC04M052410

Summaries for NMU Gene

Entrez Gene Summary for NMU Gene

  • This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

GeneCards Summary for NMU Gene

NMU (Neuromedin U) is a Protein Coding gene. Diseases associated with NMU include Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neuromedin U receptor binding.

UniProtKB/Swiss-Prot for NMU Gene

  • Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
  • Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.
  • Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.

Additional gene information for NMU Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMU Gene

Genomics for NMU Gene

GeneHancer (GH) Regulatory Elements for NMU Gene

Promoters and enhancers for NMU Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J055635 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 620.4 -0.1 -108 3.2 ZFX ZNF148 MLLT1 ZNF384 CTCF BACH1 EGR1 SMARCA4 MTA1 GMEB1 NMU AASDH CLOCK ENSG00000269921 CEP135 EXOC1 SRD5A3 TMEM165 LOC105377660
GH04J055634 Promoter 0.6 Ensembl 610.3 +1.8 1797 0.2 PRDM10 NMU PDCL2
GH04J055394 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +239.0 239016 5.4 CC2D1A ZFX ZNF148 NKRF POLR2A MLLT1 ZNF121 GTF2F1 ZNF687 ZSCAN21 TMEM165 SRD5A3-AS1 GC04P055398 RN7SKP30 CLOCK AASDH SRD5A3 NMU CEP135 ENSG00000272969
GH04J055543 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.6 +90.5 90516 5.2 SP1 ZFX ZNF148 NKRF MLLT1 GTF2F1 ZNF687 MAFK ZBTB7A TRIM24 CLOCK ENSG00000272969 RN7SKP30 TMEM165 AASDH CEP135 SRP72 NMU EXOC1 SRD5A3
GH04J055608 Enhancer 0.6 Ensembl ENCODE 28.7 +26.7 26697 3.2 NR2C1 KLF1 NMU TMEM165 KDR SRD5A3 PDCL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMU on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NMU gene promoter:
  • aMEF-2
  • CUTL1
  • Lhx3a
  • LHX3b
  • MEF-2A
  • Msx-1
  • Nkx2-2
  • PPAR-gamma1
  • PPAR-gamma2
  • S8

Genomic Locations for NMU Gene

Genomic Locations for NMU Gene
chr4:55,595,229-55,636,698
(GRCh38/hg38)
Size:
41,470 bases
Orientation:
Minus strand
chr4:56,461,396-56,502,865
(GRCh37/hg19)
Size:
41,470 bases
Orientation:
Minus strand

Genomic View for NMU Gene

Genes around NMU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMU Gene

Proteins for NMU Gene

  • Protein details for NMU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48645-NMU_HUMAN
    Recommended name:
    Neuromedin-U
    Protein Accession:
    P48645

    Protein attributes for NMU Gene

    Size:
    174 amino acids
    Molecular mass:
    19741 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMU Gene

Post-translational modifications for NMU Gene

  • Glycosylation at posLast=109109
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NMU Gene

Domains & Families for NMU Gene

Gene Families for NMU Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NMU Gene

Suggested Antigen Peptide Sequences for NMU Gene

GenScript: Design optimal peptide antigens:
  • Neuromedin-U (NMU_HUMAN)
  • Neuromedin U (Q1EHW1_HUMAN)
  • Neuromedin U (Q86WB4_HUMAN)
  • Neuromedin U (Q86WB5_HUMAN)
  • Neuromedin U (Q86WB6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48645

UniProtKB/Swiss-Prot:

NMU_HUMAN :
  • Belongs to the NmU family.
Family:
  • Belongs to the NmU family.
genes like me logo Genes that share domains with NMU: view

Function for NMU Gene

Molecular function for NMU Gene

UniProtKB/Swiss-Prot Function:
Neuromedin-U-25: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
UniProtKB/Swiss-Prot Function:
Neuromedin precursor-related peptide 33: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.
UniProtKB/Swiss-Prot Function:
Neuromedin precursor-related peptide 36: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
GENATLAS Biochemistry:
neuromedin U precursor containing potential proteolytic processing sites generating putative associated peptides,expressed in the gastrointestinal tract

Phenotypes From GWAS Catalog for NMU Gene

Gene Ontology (GO) - Molecular Function for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 10811630
GO:0005515 protein binding IPI 25416956
GO:0031839 type 1 neuromedin U receptor binding IDA 10894543
GO:0031840 type 2 neuromedin U receptor binding IDA 10894543
GO:0042922 neuromedin U receptor binding IBA 21873635
genes like me logo Genes that share ontologies with NMU: view
genes like me logo Genes that share phenotypes with NMU: view

Animal Models for NMU Gene

MGI Knock Outs for NMU:
  • Nmu Nmu<tm1Sjab>
  • Nmu Nmu<tm1Mko>

Animal Model Products

  • Taconic Biosciences Mouse Models for NMU

miRNA for NMU Gene

miRTarBase miRNAs that target NMU

Clone Products

  • Applied Biological Materials (abm): Clones for NMU - Now 50% OFF >
  • * NMU as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NMU tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMU Gene

Localization for NMU Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMU gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043195 terminal bouton IBA 21873635
genes like me logo Genes that share ontologies with NMU: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NMU Gene

Pathways & Interactions for NMU Gene

genes like me logo Genes that share pathways with NMU: view

Gene Ontology (GO) - Biological Process for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0001696 gastric acid secretion IEA --
GO:0006940 regulation of smooth muscle contraction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with NMU: view

No data available for SIGNOR curated interactions for NMU Gene

Drugs & Compounds for NMU Gene

(4) Drugs for NMU Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NMU: view

Transcripts for NMU Gene

Unigene Clusters for NMU Gene

Neuromedin U:
Representative Sequences:

Clone Products

  • Applied Biological Materials (abm): Clones for NMU - Now 50% OFF >
  • * NMU as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NMU tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NMU Gene

No ASD Table

Relevant External Links for NMU Gene

GeneLoc Exon Structure for
NMU
ECgene alternative splicing isoforms for
NMU

Expression for NMU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMU Gene

mRNA differential expression in normal tissues according to GTEx for NMU Gene

This gene is overexpressed in Esophagus - Mucosa (x22.6), Vagina (x6.4), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NMU Gene



NURSA nuclear receptor signaling pathways regulating expression of NMU Gene:

NMU

SOURCE GeneReport for Unigene cluster for NMU Gene:

Hs.418367

mRNA Expression by UniProt/SwissProt for NMU Gene:

P48645-NMU_HUMAN
Tissue specificity: Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

Evidence on tissue expression from TISSUES for NMU Gene

  • Nervous system(4.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with NMU: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMU Gene

Orthologs for NMU Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMU 35 34
  • 99.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NMU 35 34
  • 85.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NMU 34
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Nmu 17 35 34
  • 79.84 (n)
rat
(Rattus norvegicus)
Mammalia Nmu 34
  • 78.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NMU 35
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMU 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMU 35 34
  • 70.51 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMU 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmu 34
  • 66.37 (n)
zebrafish
(Danio rerio)
Actinopterygii nmu 35 34
  • 56.39 (n)
OneToOne
Species where no ortholog for NMU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMU Gene

ENSEMBL:
Gene Tree for NMU (if available)
TreeFam:
Gene Tree for NMU (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMU: view image

Paralogs for NMU Gene

(1) SIMAP similar genes for NMU Gene using alignment to 8 proteins:

  • NMU_HUMAN
  • D6RBC9_HUMAN
  • E9PDJ7_HUMAN
  • Q1EHW1_HUMAN
  • Q86WB4_HUMAN
  • Q86WB5_HUMAN
  • Q86WB6_HUMAN
  • Q9NYL6_HUMAN
genes like me logo Genes that share paralogs with NMU: view

No data available for Paralogs for NMU Gene

Variants for NMU Gene

Sequence variations from dbSNP and Humsavar for NMU Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000042498 -- 55,608,438(-) T/C intron_variant
rs10000512 -- 55,602,855(-) C/A intron_variant
rs10000850 -- 55,634,211(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000142990 -- 55,601,201(-) C/A intron_variant
rs1000283026 -- 55,633,257(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NMU Gene

Variant ID Type Subtype PubMed ID
dgv1482e212 CNV loss 25503493
esv2658731 CNV deletion 23128226
esv2675934 CNV deletion 23128226
esv2676033 CNV deletion 23128226
esv2727637 CNV deletion 23290073
esv2762435 CNV loss 21179565
esv3600554 CNV loss 21293372
esv3600555 CNV loss 21293372
esv3600559 CNV loss 21293372
nsv10496 CNV loss 18304495
nsv509899 OTHER sequence alteration 20534489

Variation tolerance for NMU Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMU
Human Gene Mutation Database (HGMD)
NMU

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMU Gene

Disorders for NMU Gene

MalaCards: The human disease database

(1) MalaCards diseases for NMU Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search NMU in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NMU

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NMU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMU Gene

Publications for NMU Gene

  1. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. (PMID: 7619205) Austin C … Bloom SR (Journal of molecular endocrinology 1995) 2 3 4 23 58
  2. Association between neuromedin U gene variants and overweight and obesity. (PMID: 16984985) Hainerová I … Pedersen O (The Journal of clinical endocrinology and metabolism 2006) 3 23 45 58
  3. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 45 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  5. Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. (PMID: 19118941) Ketterer K … Friess H (Cancer letters 2009) 3 23 58

Products for NMU Gene

Sources for NMU Gene

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