NMT2 Gene (Protein Coding)

N-Myristoyltransferase 2

GC10M015144
GIFtS:
40
This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) ... See more...

Aliases for NMT2 Gene

Aliases for NMT2 Gene

  • N-Myristoyltransferase 2 2 3 5
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2 3 4
  • Glycylpeptide N-Tetradecanoyltransferase 2 3 4
  • Peptide N-Myristoyltransferase 2 3 4
  • Type II N-Myristoyltransferase 3 4
  • EC 2.3.1.97 4 51
  • NMT 2 3 4
  • Glycylpeptide N-Tetradecanoyltransferase 2 Variant 3 3
  • Glycylpeptide N-Tetradecanoyltransferase 2 Variant 4 3
  • NMT2 5

External Ids for NMT2 Gene

Previous GeneCards Identifiers for NMT2 Gene

  • GC10M015132
  • GC10M015300
  • GC10M015153
  • GC10M015189
  • GC10M015172
  • GC10M015060

Summaries for NMT2 Gene

Entrez Gene Summary for NMT2 Gene

  • This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for NMT2 Gene

NMT2 (N-Myristoyltransferase 2) is a Protein Coding gene. Diseases associated with NMT2 include Human Immunodeficiency Virus Type 1. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity. An important paralog of this gene is NMT1.

UniProtKB/Swiss-Prot Summary for NMT2 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Gene Wiki entry for NMT2 Gene

Additional gene information for NMT2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NMT2 Gene

Genomics for NMT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NMT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J015167 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 612.7 +0.0 13 5.4 HNRNPL CTCF PRDM10 LEF1 POLR2A ZNF692 BACH1 JUND FOXA1 LARP7 NMT2 lnc-RPP38-2 HSPA14 RPP38 ENSG00000228181 LOC107984162 lnc-NMT2-3 PPIAP30
GH10J015140 Enhancer 1 Ensembl ENCODE 17.6 +26.7 26692 3.2 SP1 BACH1 STAT3 PRDM1 TCF12 IKZF2 TRIM22 HDAC1 FOXJ2 EED NMT2 ACBD7 ENSG00000228181 RPP38 RPP38-DT GAPDHP45 DCLRE1CP1 FAM171A1 LOC107984210 PPIAP30
GH10J015195 Enhancer 0.8 ENCODE dbSUPER 16.7 -28.6 -28612 3.3 CREB1 ZNF512 JUND PKNOX1 ATF1 USF1 NR2C2 NR2F1 CREM ATF3 NMT2 lnc-NMT2-1 LOC105376434 FAM171A1
GH10J015199 Enhancer 0.9 ENCODE dbSUPER 12.7 -32.7 -32725 4.3 CREB1 ATF7 TEAD4 PRDM10 ZNF629 PRDM1 REST SOX6 SOX13 CEBPB NMT2 RPP38 RPP38-DT GAPDHP45 FAM171A1 LOC105376434 lnc-NMT2-1
GH10J015144 Enhancer 0.5 Ensembl 19.3 +22.8 22792 2.6 GABPA REST GABPB1 ZNF384 CTCF NMT2 RPP38 ENSG00000228181 RPP38-DT GAPDHP45 FAM171A1 ACBD7 PPIAP30 LOC107984210
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NMT2

Top Transcription factor binding sites by QIAGEN in the NMT2 gene promoter:
  • Bach1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HFH-1
  • Sox9
  • SRF

Genomic Locations for NMT2 Gene

Genomic Locations for NMT2 Gene
chr10:15,102,584-15,168,693
(GRCh38/hg38)
Size:
66,110 bases
Orientation:
Minus strand
chr10:15,144,583-15,210,695
(GRCh37/hg19)
Size:
66,113 bases
Orientation:
Minus strand

Genomic View for NMT2 Gene

Genes around NMT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMT2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NMT2 Gene

Proteins for NMT2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60551-NMT2_HUMAN
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 2
    Protein Accession:
    O60551
    Secondary Accessions:
    • B0YJ49
    • Q53Y38
    • Q5VUC8
    • Q9BRB4

    Protein attributes for NMT2 Gene

    Size:
    498 amino acids
    Molecular mass:
    56980 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NMT2 Gene

neXtProt entry for NMT2 Gene

Protein Expression for NMT2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for NMT2 Gene

O60551:
  • KLVGFIS
  • IIDTFVVE
  • GDGNLQYYLYNW
  • EFLLWAL
  • HKSLKAAYSFYN
  • TPLLDLMSDAL
  • WALRPPG
  • INFLCVHKKLRSKR
  • FRFDYSPEFL
  • YWHRSLNP
  • NYVEDDD
  • QAVYTAGV
  • FWDTQPVPK
  • EITRRVN
  • QWHCGVRV
  • EVKFSHLSRNMT
  • TDFLSFYTLPST

Post-translational modifications for NMT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NMT2 Gene

Gene Families for NMT2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NMT2 Gene

InterPro:
Blocks:
  • Myristoyl-CoA:protein N-myristoyltransferase
ProtoNet:

Suggested Antigen Peptide Sequences for NMT2 Gene

GenScript: Design optimal peptide antigens:
  • Glycylpeptide N-tetradecanoyltransferase (B4DXS1_HUMAN)
  • Glycylpeptide N-tetradecanoyltransferase (E9PE74_HUMAN)
  • Glycylpeptide N-tetradecanoyltransferase (F5H594_HUMAN)
  • Type II N-myristoyltransferase (NMT2_HUMAN)
  • Glycylpeptide N-tetradecanoyltransferase (Q5VUC6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60551

UniProtKB/Swiss-Prot:

NMT2_HUMAN :
  • Belongs to the NMT family.
Family:
  • Belongs to the NMT family.
genes like me logo Genes that share domains with NMT2: view

Function for NMT2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NMT2 Gene

UniProtKB/Swiss-Prot Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]; Xref=Rhea:RHEA:15521, Rhea:RHEA-COMP:12666, Rhea:RHEA-COMP:12667, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:64723, ChEBI:CHEBI:133050; EC=2.3.1.97; Evidence={ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9506952};.

Enzyme Numbers (IUBMB) for NMT2 Gene

Phenotypes From GWAS Catalog for NMT2 Gene

Gene Ontology (GO) - Molecular Function for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity IEA,TAS --
GO:0005515 protein binding IPI 16530191
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NMT2: view
genes like me logo Genes that share phenotypes with NMT2: view

Animal Models for NMT2 Gene

MGI Knock Outs for NMT2:
  • Nmt2 Nmt2<tm2b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for NMT2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMT2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMT2 Gene

Localization for NMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT2 Gene

Cytoplasm. Membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMT2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
golgi apparatus 4
nucleus 3
mitochondrion 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 9506952
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NMT2: view

Pathways & Interactions for NMT2 Gene

genes like me logo Genes that share pathways with NMT2: view

Gene Ontology (GO) - Biological Process for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006499 N-terminal protein myristoylation IEA --
GO:0018008 N-terminal peptidyl-glycine N-myristoylation IDA 25255805
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:0075733 intracellular transport of virus TAS --
genes like me logo Genes that share ontologies with NMT2: view

No data available for SIGNOR curated interactions for NMT2 Gene

Drugs & Compounds for NMT2 Gene

Products:

  1. Drug

(5) Drugs for NMT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
myristoyl-coa Experimental Pharma Target 0
(Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE Experimental Pharma Target 0
1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL Experimental Pharma Target 0
S-(2-oxo)pentadecylcoa Experimental Pharma Target 0
Coenzyme A Investigational Nutra 0
genes like me logo Genes that share compounds with NMT2: view

Transcripts for NMT2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NMT2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMT2

Alternative Splicing Database (ASD) splice patterns (SP) for NMT2 Gene

No ASD Table

Relevant External Links for NMT2 Gene

GeneLoc Exon Structure for
NMT2

Expression for NMT2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NMT2 Gene

mRNA expression in normal human tissues for NMT2 Gene
mRNA expression by GTEx for NMT2 GenemRNA expression by BioGPS for NMT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NMT2 Gene

This gene is overexpressed in CD8 Tcells (8.8), Testis (8.0), Lung (6.7), Peripheral blood mononuclear cells (6.3), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NMT2 Gene



Protein tissue co-expression partners for NMT2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NMT2

SOURCE GeneReport for Unigene cluster for NMT2 Gene:

Hs.60339

Evidence on tissue expression from TISSUES for NMT2 Gene

  • Liver(4.4)
  • Skin(4.4)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with NMT2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMT2 Gene

Orthologs for NMT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NMT2 30 31
  • 99.52 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NMT2 31
  • 94 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NMT2 30 31
  • 90.36 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Nmt2 30 17 31
  • 88.76 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nmt2 30
  • 88.35 (n)
Dog
(Canis familiaris)
 Mammalia NMT2 30 31
  • 84.65 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia NMT2 31
  • 81 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NMT2 30 31
  • 84.27 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NMT2 31
  • 83 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia nmt1 30
  • 77.71 (n)
Zebrafish
(Danio rerio)
 Actinopterygii nmt2 30 31
  • 75 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Nmt 31 32
  • 56 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea nmt-1 30 31
  • 58.16 (n)
 OneToMany
T17E9.2a 32
  • 57 (a)
T17E9.2b 32
  • 54 (a)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AAR077C 30
  • 52.37 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E19537g 30
  • 52.32 (n)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes NMT1 30 31
  • 48.7 (n)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.8123 31
  • 56 (a)
 OneToMany
Bread mold
(Neurospora crassa)
 Ascomycetes NCU06925 30
  • 53.59 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPBC2G2.11 30
  • 53.48 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.8619 30
Species where no ortholog for NMT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NMT2 Gene

ENSEMBL:
Gene Tree for NMT2 (if available)
TreeFam:
Gene Tree for NMT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMT2: view image

Paralogs for NMT2 Gene

Paralogs for NMT2 Gene

(1) SIMAP similar genes for NMT2 Gene using alignment to 6 proteins:

  • NMT2_HUMAN
  • B4DXS1_HUMAN
  • F5H594_HUMAN
  • Q5VUC6_HUMAN
  • Q5VUC7_HUMAN
  • Q9BS83_HUMAN
genes like me logo Genes that share paralogs with NMT2: view

Variants for NMT2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for NMT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NMT2 Gene

Variant ID Type Subtype PubMed ID
esv2465251 CNV insertion 19546169
esv2666604 CNV deletion 23128226
esv3622437 CNV loss 21293372
nsv1068675 CNV deletion 25765185
nsv1078731 CNV insertion 25765185
nsv1122495 CNV deletion 24896259
nsv1146274 CNV insertion 26484159
nsv5910 CNV insertion 18451855
nsv831794 CNV loss 17160897
nsv947748 CNV duplication 23825009

Variation tolerance for NMT2 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMT2 Gene

Human Gene Mutation Database (HGMD)
NMT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NMT2 Gene

Disorders for NMT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NMT2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search NMT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NMT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NMT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMT2 Gene

Publications for NMT2 Gene

  1. A second mammalian N-myristoyltransferase. (PMID: 9506952) Giang DK … Cravatt BF (The Journal of biological chemistry 1998) 2 3 4 23
  2. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. (PMID: 25255805) Thinon E … Tate EW (Nature communications 2014) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. (PMID: 18089753) Seaton KE … Smith CD (The Journal of general virology 2008) 3 23

ExternalLinks

View latest publications for NMT2 gene in Mastermind

Products for NMT2 Gene

  • Addgene plasmids for NMT2
  • Signalway ELISA kits for NMT2
  • Signalway Proteins for NMT2

Sources for NMT2 Gene