Aliases for NMT1 Gene
External Ids for NMT1 Gene
Previous GeneCards Identifiers for NMT1 Gene
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 188.8.131.52) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]
GeneCards Summary for NMT1 Gene
NMT1 (N-Myristoyltransferase 1) is a Protein Coding gene. Diseases associated with NMT1 include Sleeping Sickness and Patent Foramen Ovale. Among its related pathways are Signaling by GPCR and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity and myristoyltransferase activity. An important paralog of this gene is NMT2.
UniProtKB/Swiss-Prot Summary for NMT1 Gene
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.