Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biol... See more...

Aliases for NMT1 Gene

Aliases for NMT1 Gene

  • N-Myristoyltransferase 1 2 3 5
  • Myristoyl-CoA:Protein N-Myristoyltransferase 1 3 4
  • Glycylpeptide N-Tetradecanoyltransferase 1 3 4
  • Type I N-Myristoyltransferase 3 4
  • Alternative, Short Form NMT-S 2 3
  • Long Form, NMT-L 2 3
  • EC 2.3.1.97 4 52
  • NMT 3 4
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2
  • Peptide N-Myristoyltransferase 1 4
  • NMT 1 4

External Ids for NMT1 Gene

Previous GeneCards Identifiers for NMT1 Gene

  • GC17M042667
  • GC17M045252
  • GC17P043149
  • GC17P043613
  • GC17P040494
  • GC17P043139
  • GC17P038903

Summaries for NMT1 Gene

Entrez Gene Summary for NMT1 Gene

  • Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

GeneCards Summary for NMT1 Gene

NMT1 (N-Myristoyltransferase 1) is a Protein Coding gene. Diseases associated with NMT1 include Gallbladder Cancer and Submandibular Adenitis. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity and myristoyltransferase activity. An important paralog of this gene is NMT2.

UniProtKB/Swiss-Prot Summary for NMT1 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Tocris Summary for NMT1 Gene

Gene Wiki entry for NMT1 Gene

Additional gene information for NMT1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NMT1 Gene

Genomics for NMT1 Gene

GeneHancer (GH) Regulatory Elements for NMT1 Gene

Promoters and enhancers for NMT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMT1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NMT1

Top Transcription factor binding sites by QIAGEN in the NMT1 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • Cart-1
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • IRF-1
  • MAZR

Genomic Locations for NMT1 Gene

Genomic Locations for NMT1 Gene
chr17:45,051,610-45,109,016
(GRCh38/hg38)
Size:
57,407 bases
Orientation:
Plus strand
chr17:43,128,978-43,186,384
(GRCh37/hg19)
Size:
57,407 bases
Orientation:
Plus strand

Genomic View for NMT1 Gene

Genes around NMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMT1 Gene

Proteins for NMT1 Gene

  • Protein details for NMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30419-NMT1_HUMAN
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 1
    Protein Accession:
    P30419
    Secondary Accessions:
    • A8K7C1
    • Q9UE09

    Protein attributes for NMT1 Gene

    Size:
    496 amino acids
    Molecular mass:
    56806 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC09294.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NMT1 Gene

    Alternative splice isoforms for NMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMT1 Gene

Selected DME Specific Peptides for NMT1 Gene

P30419:
  • IIDTFVVE
  • EFLLWAL
  • HKSLKAAYSFYN
  • EPDKDNIRQEPY
  • WALRPPG
  • INFLCVHKKLRSKR
  • QAVYTAGV
  • KDIPVVHQLL
  • QWHCGVRV
  • EVKFSHLSRNMT
  • TDFLSFYTLPST
  • MMEGNGNGHEHCSDCENEED
  • QDQPVKM
  • KLVGFIS
  • GDGNLQYYLYNW
  • TPLLDLMSDAL
  • RNMTMQRTMKLY
  • FRFDYSPEFL
  • YWHRSLNP
  • NYVEDDD
  • FWDTQPVPK

Post-translational modifications for NMT1 Gene

  • Ubiquitination at Lys94
  • Modification sites at PhosphoSitePlus

Other Protein References for NMT1 Gene

Domains & Families for NMT1 Gene

Gene Families for NMT1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NMT1 Gene

Blocks:
  • Myristoyl-CoA:protein N-myristoyltransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NMT1 Gene

GenScript: Design optimal peptide antigens:
  • Glycylpeptide N-tetradecanoyltransferase (A4FU65_HUMAN)
  • cDNA FLJ54222, highly similar to Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (B7Z8J4_HUMAN)
  • Peptide N-myristoyltransferase 1 (NMT1_HUMAN)
  • Glycylpeptide N-tetradecanoyltransferase (Q96HI4_HUMAN)
  • Myristoyl-CoA:protein N-myristoyltransferase (Q9Y465_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30419

UniProtKB/Swiss-Prot:

NMT1_HUMAN :
  • Belongs to the NMT family.
Family:
  • Belongs to the NMT family.
genes like me logo Genes that share domains with NMT1: view

Function for NMT1 Gene

Molecular function for NMT1 Gene

UniProtKB/Swiss-Prot Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]; Xref=Rhea:RHEA:15521, Rhea:RHEA-COMP:12666, Rhea:RHEA-COMP:12667, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385, ChEBI:CHEBI:64723, ChEBI:CHEBI:133050; EC=2.3.1.97; Evidence={ECO:0000269 PubMed:22865860, ECO:0000269 PubMed:25255805, ECO:0000269 PubMed:9353336, ECO:0000269 PubMed:9506952};.

Enzyme Numbers (IUBMB) for NMT1 Gene

Phenotypes From GWAS Catalog for NMT1 Gene

Gene Ontology (GO) - Molecular Function for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity IBA,IDA 25255805
GO:0005515 protein binding IPI 26621918
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019107 myristoyltransferase activity TAS --
genes like me logo Genes that share ontologies with NMT1: view
genes like me logo Genes that share phenotypes with NMT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMT1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMT1

Clone Products

  • Addgene plasmids for NMT1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMT1 Gene

Localization for NMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT1 Gene

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=Copurifies with ribosomes. {ECO:0000269 PubMed:9353336}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMT1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 3
mitochondrion 3
nucleus 3
extracellular 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 9353336
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NMT1: view

Pathways & Interactions for NMT1 Gene

genes like me logo Genes that share pathways with NMT1: view

Pathways by source for NMT1 Gene

SIGNOR curated interactions for NMT1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006499 N-terminal protein myristoylation TAS --
GO:0018008 N-terminal peptidyl-glycine N-myristoylation IDA 25255805
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:0042180 cellular ketone metabolic process IDA 22865860
genes like me logo Genes that share ontologies with NMT1: view

Drugs & Compounds for NMT1 Gene

(12) Drugs for NMT1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
myristoyl-coa Experimental Pharma Target 0
(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone Experimental Pharma Target, Target 0
N-({4-[4-(2-Methyl-1H-imidazol-1-yl)butyl]phenyl}acetyl)-L-seryl-N-(2-cyclohexylethyl)-L-lysinamide Experimental Pharma Target 0
Tunicamycin Experimental Pharma Antibiotic; GlcNAc phosphotransferase inhibitor 0
Coenzyme A Investigational Nutra 0

(8) Additional Compounds for NMT1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
P-3FAX-Neu5Ac
117405-58-0

(4) Tocris Compounds for NMT1 Gene

Compound Action Cas Number
N-Acetyltryptamine Substrate for serotonin N-acetyl transferase 1016-47-3
P-3FAX-Neu5Ac Sialic acid analog; sialyltransferase inhibitor 117405-58-0
SKF 91488 dihydrochloride Histamine N-methyltransferase inhibitor 68941-21-9
Tunicamycin Antibiotic; GlcNAc phosphotransferase inhibitor 11089-65-9

(1) ApexBio Compounds for NMT1 Gene

Compound Action Cas Number
Tris DBA 51364-51-3
genes like me logo Genes that share compounds with NMT1: view

Drug Products

Transcripts for NMT1 Gene

mRNA/cDNA for NMT1 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMT1

Clone Products

  • Addgene plasmids for NMT1

Alternative Splicing Database (ASD) splice patterns (SP) for NMT1 Gene

No ASD Table

Relevant External Links for NMT1 Gene

GeneLoc Exon Structure for
NMT1

Expression for NMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NMT1 Gene

Protein differential expression in normal tissues from HIPED for NMT1 Gene

This gene is overexpressed in Bone marrow stromal cell (10.7) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NMT1 Gene



Protein tissue co-expression partners for NMT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NMT1

SOURCE GeneReport for Unigene cluster for NMT1 Gene:

Hs.532790

mRNA Expression by UniProt/SwissProt for NMT1 Gene:

P30419-NMT1_HUMAN
Tissue specificity: Heart, gut, kidney, liver and placenta.

Evidence on tissue expression from TISSUES for NMT1 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Skin(4.5)
  • Muscle(4.4)
  • Eye(2.8)
  • Lung(2.4)
  • Intestine(2.2)
  • Pancreas(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with NMT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMT1 Gene

Orthologs for NMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMT1 31 30
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NMT1 31 30
  • 94.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NMT1 31 30
  • 93.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nmt1 17 31 30
  • 90.93 (n)
rat
(Rattus norvegicus)
Mammalia Nmt1 30
  • 90.93 (n)
oppossum
(Monodelphis domestica)
Mammalia NMT1 31
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMT1 31 30
  • 82.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMT1 31
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmt2 30
  • 76.38 (n)
Str.12909 30
African clawed frog
(Xenopus laevis)
Amphibia nmt1-prov 30
zebrafish
(Danio rerio)
Actinopterygii nmt1a 31 30
  • 74.97 (n)
OneToOne
wufc15d01 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001804 30
  • 65.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nmt 31 32 30
  • 63.38 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T17E9.2a 32
  • 57 (a)
T17E9.2b 32
  • 57 (a)
nmt-1 31
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMT1 33 31
  • 41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NMT1 30
  • 59.21 (n)
rice
(Oryza sativa)
Liliopsida Os01g0708100 30
  • 62.23 (n)
Os.15143 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8123 31
  • 56 (a)
OneToMany
Species where no ortholog for NMT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMT1 Gene

ENSEMBL:
Gene Tree for NMT1 (if available)
TreeFam:
Gene Tree for NMT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMT1: view image

Paralogs for NMT1 Gene

Paralogs for NMT1 Gene

(2) SIMAP similar genes for NMT1 Gene using alignment to 6 proteins:

  • NMT1_HUMAN
  • A4FU65_HUMAN
  • B7Z8J4_HUMAN
  • K7EN42_HUMAN
  • K7EN82_HUMAN
  • Q96HI4_HUMAN
genes like me logo Genes that share paralogs with NMT1: view

Variants for NMT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NMT1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs3087878 - p.Gln61Lys

Additional dbSNP identifiers (rs#s) for NMT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NMT1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv527788 CNV loss 19592680
nsv833457 CNV loss 17160897
nsv953903 CNV deletion 24416366

Variation tolerance for NMT1 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMT1 Gene

Disorders for NMT1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for NMT1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
gallbladder cancer
  • gallbladder ca
submandibular adenitis
  • submandibular lymphadenitis
thoracic outlet syndrome
  • tos - thoracic outlet syndrome
patent foramen ovale
  • atrial septal defect within oval fossa
sleeping sickness
  • african sleeping sickness
- elite association - COSMIC cancer census association via MalaCards
Search NMT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NMT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NMT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMT1 Gene

Publications for NMT1 Gene

  1. Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae. (PMID: 1570339) Duronio RJ … Gordon JI (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 23 54
  2. Characterization of human and rat brain myristoyl-CoA:protein N-myristoyltransferase: evidence for an alternative splice variant of the enzyme. (PMID: 9677304) McIlhinney RA … Soloviev M (The Biochemical journal 1998) 3 4 23 54
  3. A second mammalian N-myristoyltransferase. (PMID: 9506952) Giang DK … Cravatt BF (The Journal of biological chemistry 1998) 3 4 23 54
  4. Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction. (PMID: 9353336) Glover CJ … Felsted RL (The Journal of biological chemistry 1997) 3 4 23 54
  5. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. (PMID: 25255805) Thinon E … Tate EW (Nature communications 2014) 3 4 54

Products for NMT1 Gene

  • Signalway ELISA kits for NMT1
  • Signalway Proteins for NMT1

Sources for NMT1 Gene