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Aliases for NMS Gene

Aliases for NMS Gene

  • Neuromedin S 2 3 5
  • Prepro-NMS 2 3
  • Neuromedin S Precursor-Related Peptide/Neuromedin S Preproprotein 3
  • Neuromedin-S 3

External Ids for NMS Gene

Previous GeneCards Identifiers for NMS Gene

  • GC02P100546
  • GC02P101086
  • GC02P094851

Summaries for NMS Gene

Entrez Gene Summary for NMS Gene

  • This gene encodes a member of the neuromedin family of neuropeptides. The encoded preproprotein is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. [provided by RefSeq, May 2016]

GeneCards Summary for NMS Gene

NMS (Neuromedin S) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes.

UniProtKB/Swiss-Prot for NMS Gene

  • Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.

Additional gene information for NMS Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMS Gene

Genomics for NMS Gene

GeneHancer (GH) Regulatory Elements for NMS Gene

Promoters and enhancers for NMS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I100478 Enhancer 0.2 FANTOM5 11.4 +8.2 8162 0.4 NMS LOC105373506
GH02I100584 Enhancer 0.3 FANTOM5 2.7 +114.5 114525 0.4 ZNF766 PDCL3 NMS HMGN2P22
GH02I100425 Enhancer 0.4 Ensembl 0.3 -44.4 -44381 0.6 CEBPB CEBPG LOC129522 NMS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NMS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NMS gene promoter:

Genomic Locations for NMS Gene

Genomic Locations for NMS Gene
chr2:100,470,482-100,483,280
(GRCh38/hg38)
Size:
12,799 bases
Orientation:
Plus strand
chr2:101,086,944-101,099,742
(GRCh37/hg19)

Genomic View for NMS Gene

Genes around NMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMS Gene

Proteins for NMS Gene

  • Protein details for NMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H8A3-NMS_HUMAN
    Recommended name:
    Neuromedin-S
    Protein Accession:
    Q5H8A3

    Protein attributes for NMS Gene

    Size:
    153 amino acids
    Molecular mass:
    17731 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMS Gene

Post-translational modifications for NMS Gene

No Post-translational modifications

Other Protein References for NMS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMS Gene

Domains & Families for NMS Gene

Gene Families for NMS Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NMS Gene

Suggested Antigen Peptide Sequences for NMS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5H8A3

UniProtKB/Swiss-Prot:

NMS_HUMAN :
  • Belongs to the NmU family.
Family:
  • Belongs to the NmU family.
genes like me logo Genes that share domains with NMS: view

Function for NMS Gene

Molecular function for NMS Gene

UniProtKB/Swiss-Prot Function:
Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.

Gene Ontology (GO) - Molecular Function for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
genes like me logo Genes that share ontologies with NMS: view

Phenotypes for NMS Gene

genes like me logo Genes that share phenotypes with NMS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NMS Gene

Localization for NMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMS gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NMS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NMS Gene

Pathways & Interactions for NMS Gene

genes like me logo Genes that share pathways with NMS: view

SIGNOR curated interactions for NMS Gene

Activates:

Gene Ontology (GO) - Biological Process for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0045475 locomotor rhythm IEA,IBA --
genes like me logo Genes that share ontologies with NMS: view

Drugs & Compounds for NMS Gene

(1) Drugs for NMS Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antipsychotic Agents Pharma 2483
genes like me logo Genes that share compounds with NMS: view

Transcripts for NMS Gene

mRNA/cDNA for NMS Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMS Gene

No ASD Table

Relevant External Links for NMS Gene

GeneLoc Exon Structure for
NMS
ECgene alternative splicing isoforms for
NMS

Expression for NMS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMS Gene

This gene is overexpressed in Brain - Hypothalamus (x34.3) and Brain - Spinal cord (cervical c-1) (x13.1).

Protein differential expression in normal tissues from HIPED for NMS Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NMS Gene



Protein tissue co-expression partners for NMS Gene

NURSA nuclear receptor signaling pathways regulating expression of NMS Gene:

NMS

SOURCE GeneReport for Unigene cluster for NMS Gene:

Hs.567676

Evidence on tissue expression from TISSUES for NMS Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NMS: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMS Gene

Orthologs for NMS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMS 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia NMS 33 34
  • 86.44 (n)
cow
(Bos Taurus)
Mammalia NMS 33 34
  • 84.63 (n)
mouse
(Mus musculus)
Mammalia Nms 33 16 34
  • 76.44 (n)
rat
(Rattus norvegicus)
Mammalia NMS 33
  • 75.8 (n)
zebrafish
(Danio rerio)
Actinopterygii -- 33
Species where no ortholog for NMS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMS Gene

ENSEMBL:
Gene Tree for NMS (if available)
TreeFam:
Gene Tree for NMS (if available)

Paralogs for NMS Gene

(1) SIMAP similar genes for NMS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NMS: view

No data available for Paralogs for NMS Gene

Variants for NMS Gene

Sequence variations from dbSNP and Humsavar for NMS Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000055394 -- 100,475,166(+) G/A intron_variant
rs1000174363 -- 100,471,942(+) C/T intron_variant
rs1000345900 -- 100,477,437(+) C/A intron_variant
rs1000395533 -- 100,480,118(+) G/A intron_variant
rs1000411578 -- 100,483,453(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NMS Gene

Variant ID Type Subtype PubMed ID
nsv834312 CNV loss 17160897
nsv582533 CNV loss 21841781
nsv582532 CNV gain 21841781
nsv582531 CNV gain 21841781
nsv1011990 CNV gain 25217958

Variation tolerance for NMS Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMS Gene

Human Gene Mutation Database (HGMD)
NMS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMS Gene

Disorders for NMS Gene

Additional Disease Information for NMS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NMS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMS Gene

Publications for NMS Gene

  1. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. (PMID: 15635449) Mori K … Kangawa K (The EMBO journal 2005) 2 3 4 58
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  3. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. (PMID: 19519756) Mitchell JD … Davenport AP (British journal of pharmacology 2009) 3 22 58
  4. Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. (PMID: 18987052) Mitchell JD … Davenport AP (Cardiovascular research 2009) 3 22 58
  5. Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release. (PMID: 28874765) Mori K … Kangawa K (Scientific reports 2017) 3 58

Products for NMS Gene

Sources for NMS Gene

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