This gene encodes a member of the neuromedin family of neuropeptides. The encoded preproprotein is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. [provided by RefSeq, May 2016] See more...

Aliases for NMS Gene

Aliases for NMS Gene

  • Neuromedin S 2 3 5
  • Neuromedin-S 3 4
  • Prepro-NMS 2 3
  • Neuromedin S Precursor-Related Peptide/Neuromedin S Preproprotein 3
  • NMS 5

External Ids for NMS Gene

Previous GeneCards Identifiers for NMS Gene

  • GC02P100546
  • GC02P101086
  • GC02P094851

Summaries for NMS Gene

Entrez Gene Summary for NMS Gene

  • This gene encodes a member of the neuromedin family of neuropeptides. The encoded preproprotein is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. [provided by RefSeq, May 2016]

GeneCards Summary for NMS Gene

NMS (Neuromedin S) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors.

UniProtKB/Swiss-Prot Summary for NMS Gene

  • Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NMS Gene

Genomics for NMS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NMS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J100467 Enhancer 0.8 Ensembl 250.7 +0.5 463 0.7 MXD4 THAP11 SIN3A REST ZNF511 SAP130 MIER3 ZSCAN9 ETV4 KMT2B NMS RF00017-3278 PDCL3 HSALNG0017300
GH02J100421 Enhancer 0.5 Ensembl 11.1 -48.2 -48181 1.4 CTCF RAD21 SMC3 XRCC5 TRIM22 PDCL3 NMS CHST10 RALBP1P2
GH02J100478 Enhancer 0.3 FANTOM5 11.4 +8.2 8162 0.4 EZH2 NMS HSALNG0017300 LOC105373506 PDCL3
GH02J100584 Enhancer 0.5 FANTOM5 Ensembl 2.7 +114.3 114319 0.8 ZNF766 PDCL3 NMS HMGN2P22 SNODB1241 NPAS2
GH02J100561 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +92.4 92386 3.1 CHD2 TBP MXD4 FEZF1 ZNF217 SIX5 NR2C1 MNT SMAD5 ETS1 PDCL3 lnc-CHST10-4 NMS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NMS

Top Transcription factor binding sites by QIAGEN in the NMS gene promoter:
  • AML1a
  • Cdc5
  • CUTL1
  • Evi-1
  • IRF-2
  • NF-YC
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • STAT1

Genomic Locations for NMS Gene

Latest Assembly
chr2:100,470,482-100,483,280
(GRCh38/hg38)
Size:
12,799 bases
Orientation:
Plus strand

Previous Assembly
chr2:101,086,944-101,099,742
(GRCh37/hg19 by Entrez Gene)
Size:
12,799 bases
Orientation:
Plus strand

chr2:101,086,944-101,099,742
(GRCh37/hg19 by Ensembl)
Size:
12,799 bases
Orientation:
Plus strand

Genomic View for NMS Gene

Genes around NMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMS Gene

Proteins for NMS Gene

  • Protein details for NMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H8A3-NMS_HUMAN
    Recommended name:
    Neuromedin-S
    Protein Accession:
    Q5H8A3

    Protein attributes for NMS Gene

    Size:
    153 amino acids
    Molecular mass:
    17731 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMS Gene

Post-translational modifications for NMS Gene

No Post-translational modifications

Other Protein References for NMS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMS Gene

Domains & Families for NMS Gene

Gene Families for NMS Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NMS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NMS Gene

GenScript: Design optimal peptide antigens:
  • Neuromedin-S (NMS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5H8A3

UniProtKB/Swiss-Prot:

NMS_HUMAN :
  • Belongs to the NmU family.
Family:
  • Belongs to the NmU family.
genes like me logo Genes that share domains with NMS: view

Function for NMS Gene

Molecular function for NMS Gene

UniProtKB/Swiss-Prot Function:
Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.

Phenotypes From GWAS Catalog for NMS Gene

Gene Ontology (GO) - Molecular Function for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IEA --
genes like me logo Genes that share ontologies with NMS: view
genes like me logo Genes that share phenotypes with NMS: view

Animal Models for research

  • Taconic Biosciences Mouse Models for NMS

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NMS Gene

Localization for NMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMS gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NMS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NMS Gene

Pathways & Interactions for NMS Gene

genes like me logo Genes that share pathways with NMS: view

SIGNOR curated interactions for NMS Gene

Activates:

Gene Ontology (GO) - Biological Process for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0045475 locomotor rhythm IEA --
genes like me logo Genes that share ontologies with NMS: view

Drugs & Compounds for NMS Gene

(1) Drugs for NMS Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antipsychotic Agents Pharma 2818
genes like me logo Genes that share compounds with NMS: view

Transcripts for NMS Gene

mRNA/cDNA for NMS Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMS

Alternative Splicing Database (ASD) splice patterns (SP) for NMS Gene

No ASD Table

Relevant External Links for NMS Gene

GeneLoc Exon Structure for
NMS

Expression for NMS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMS Gene

This gene is overexpressed in Brain - Hypothalamus (x34.3) and Brain - Spinal cord (cervical c-1) (x13.1).

Protein differential expression in normal tissues from HIPED for NMS Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NMS Gene



Protein tissue co-expression partners for NMS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NMS

SOURCE GeneReport for Unigene cluster for NMS Gene:

Hs.567676

Evidence on tissue expression from TISSUES for NMS Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NMS: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMS Gene

Orthologs for NMS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NMS 30 31
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NMS 30 31
  • 86.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NMS 30 31
  • 84.63 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nms 30 17 31
  • 76.44 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia NMS 30
  • 75.8 (n)
Zebrafish
(Danio rerio)
Actinopterygii -- 30
Species where no ortholog for NMS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NMS Gene

ENSEMBL:
Gene Tree for NMS (if available)
TreeFam:
Gene Tree for NMS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMS: view image

Paralogs for NMS Gene

(1) SIMAP similar genes for NMS Gene using alignment to 1 proteins:

  • NMS_HUMAN
genes like me logo Genes that share paralogs with NMS: view

No data available for Paralogs for NMS Gene

Variants for NMS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NMS Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs59029020 Benign: not provided 100,470,489(+) A/G
NM_001011717.1(NMS):c.1A>G (p.Met1Val)
INITIATIOR_CODON_VARIANT,MISSENSE
rs13411940 - p.Pro6Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NMS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NMS Gene

Variant ID Type Subtype PubMed ID
nsv1011990 CNV gain 25217958
nsv582531 CNV gain 21841781
nsv582532 CNV gain 21841781
nsv582533 CNV loss 21841781
nsv834312 CNV loss 17160897

Variation tolerance for NMS Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMS Gene

Human Gene Mutation Database (HGMD)
NMS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMS Gene

Disorders for NMS Gene

Additional Disease Information for NMS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for NMS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMS Gene

Publications for NMS Gene

  1. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. (PMID: 15635449) Mori K … Kangawa K (The EMBO journal 2005) 2 3 4
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41
  3. Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. (PMID: 18987052) Mitchell JD … Davenport AP (Cardiovascular research 2009) 3 23
  4. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. (PMID: 19519756) Mitchell JD … Davenport AP (British journal of pharmacology 2009) 3 23
  5. Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release. (PMID: 28874765) Mori K … Kangawa K (Scientific reports 2017) 3

Products for NMS Gene

Sources for NMS Gene